Patents by Inventor Sebastian Raimundo

Sebastian Raimundo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120270948
    Abstract: Provided are polynucleotides of molecular variant promoters of the CYP2D6 gene which, for example, are associated with abnormal drug response or individual predisposition to several common diseases and disorders caused by drug under- or over-metabolization, and vectors comprising such polynucleotides. Furthermore, methods of diagnosing the status of disorders related to intermediate metabolization of drugs are described. In addition, kits comprising oligonucleotides hybridizing to the CYP2D6 promoter and/or being capable of being extended into this region useful for diagnosing subjects that are ultrarapid or intermediate metabolizer of drugs are provided.
    Type: Application
    Filed: January 13, 2012
    Publication date: October 25, 2012
    Inventors: Sebastian Raimundo, Ulrich Zanger
  • Patent number: 8129112
    Abstract: Provided are polynucleotides of molecular variant promoters of the CYP2D6 gene which, for example, are associated with abnormal drug response or individual predisposition to several common diseases and disorders caused by drug under- or over-metabolization, and vectors comprising such polynucleotides. Furthermore, methods of diagnosing the status of disorders related to intermediate metabolization of drugs are described. In addition, kits comprising oligonucleotides hybridizing to the CYP2D6 promoter and/or being capable of being extended into this region useful for diagnosing subjects that are ultrarapid or intermediate metabolizer of drugs are provided.
    Type: Grant
    Filed: January 30, 2001
    Date of Patent: March 6, 2012
    Assignee: PGxHealth, LLC
    Inventors: Sebastian Raimundo, Ulrich Zanger
  • Publication number: 20050032070
    Abstract: The present invention relates to means and methods of diagnosing and treating the phenotypic spectrum as well as the overlapping clinical characteristics with several forms of inherited abnormal expression and/or function of the CYP2D6 gene. In particular, the present invention relates to polynucleotides of molecular variants of the CYP2D6 gene, which for example, are associated with abnormal drug response and disorders caused by altered activity of the CYP2D6 enzyme, and vectors comprising these polynucleotides. Furthermore, the present invention relates to host cells comprising such polynucleotides or vectors. The invention also relates to a transgenic non-human animal. Furthermore, kits comprising oligonucleotides hybridizing to the CYP2D6 gene useful for the diagnosis of an altered activity of the CYP2D6 enzyme are provided. In addition, the invention relates to methods for diagnosing a polynucleotide associated with an intermediate metabolizer phenotype of CYP2D6 drugs.
    Type: Application
    Filed: August 5, 2003
    Publication date: February 10, 2005
    Inventors: Sebastian Raimundo, Ulrich Zanger