Abstract: Diagnosis, treatment and prophylaxis of diseases and conditions associated with smooth muscle cell (SMC) dysfunction are provided through the inhibition or IL-11-mediated signalling.

Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

Abstract: A vehicle steering wheel system is provided. The system includes a steering wheel body with a hub region for attachment to a steering shaft of a vehicle steering system, a steering wheel rim and at least one spoke for attaching the steering wheel rim to the hub region; an electromechanical triggering device for triggering an acoustic output by means of an acoustic warning device of the vehicle, wherein the triggering device has an impact absorber cover and at least one force transducer wherein a force value threshold is predefined for each force transducer, and a wake-up signal is transmitted via the data connection to the evaluation unit if the force value threshold is exceeded by at least one force value, so that the latter changes from the energy-saving mode into the operating mode in which an actuating force value is determined by force value measured by the at least one force transducer.

Abstract: Methods of treating and preventing metabolic disease through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: Diagnosis, treatment and prophylaxis of diseases and conditions associated with smooth muscle cell (SMC) dysfunction are provided through the inhibition of IL-11-mediated signalling.

Abstract: Methods of treating and preventing Alport syndrome through inhibiting interleukin 11 (EL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: A method for evaluating image data of a patient showing a target region to be treated with an embolizing agent includes providing a three-dimensional time-resolved image data set of a vascular system portion of the patient. A structural parameter that describes a geometry of at least the vascular system portion and/or a basic information item including dynamic parameters that describe hemodynamics in the vascular system portion is established from the image data set by an analysis algorithm. An embolization information item describing a plurality of embolizing agents that are to be used is provided. An actuation information item describing a suitable composition of the plurality of embolizing agents, for an intervention facility used for carrying out the treatment is established by an establishing algorithm that uses the basic information item and the embolization information item, and the actuation information item is provided to the intervention facility.

Abstract: A method of producing a biodegradable cartridge having a predominantly elongated cylindrical shape having a cavity, including steps of providing a first element of a sheet form into a cylindrical form; providing a second element to the cavity of a first end of the cartridge, thereby closing the first end of the cartridge; providing another second element to the cavity of a second end of the cartridge, thereby closing the second end of the cartridge; providing a third element to the second end of the cartridge such that the periphery of the second end is larger than the periphery of the first end of the cartridge; wherein the first element, the second element and the third element are made of biodegradable materials, wherein the elements are configured for an air flow to flow from the first end to the second end of the elongated cylindrical shape cartridge, and/or vice versa.

Abstract: Systems, apparatus, and methods for reducing the decibel levels of sound originated external to a sports protective helmet may minimize deleterious effects to the hearing of the individual wearing the sports protective helmet. Through use of a sound-deflecting apparatus that is coupled to an interior surface or to an exterior surface of the sports protective helmet proximate an ear hole, decibel volumes may be constructively reduced by deflecting high frequency sound waves while allowing low frequency sound waves to reach the ear or in vicinity of the ear of the wearer of the helmet.

Abstract: Methods of treating and preventing kidney injury through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: A separator plate arrangement for an electrochemical system, comprising a first metal sheet and a second metal sheet. The first metal sheet has a first circumferential sealing structure for sealing off an electrochemically active region, a first cutout arranged outside of the first circumferential sealing structure, and a first embossed structure arranged outside of the first circumferential sealing structure. The second metal sheet has a second circumferential sealing structure for sealing off an electrochemically active region, a second cutout arranged outside of the second circumferential sealing structure, and a second embossed structure arranged outside of the second circumferential sealing structure.

Abstract: An IL-11 binding receptor capable of binding to IL-11 and inhibiting IL-11 mediated signalling is disclosed. Also disclosed are compositions comprising the IL-11 binding receptor and methods using the IL-11 binding receptor.

Abstract: Methods of treating and preventing kidney injury through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: Methods of treating and preventing hepatotoxicity through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: A bipolar plate for an electrochemical system. The bipolar plate comprising a first individual plate and a second individual plate which are joined together. Each individual plate comprising: an electrochemically active region, an outer edge, and a perimeter sealing element. The outer edge region spans between the edge of the perimeter sealing element and the outer edge. Some emobidments of the outer edges protrude out of a plate plane defined by the bipolar plate. A plurality of stiffening structures stiffening the outer edge region of the bipolar plate.

Abstract: An IL-11 binding receptor capable of binding to IL-11 and inhibiting IL-11 mediated signalling is disclosed. Also disclosed are compositions comprising the IL-11 binding receptor and methods using the IL-11 binding receptor.

Abstract: Provided are antigen-binding molecules capable of binding to IL-11R?, and methods of medical treatment and prophylaxis using the same.

Abstract: Provided are antigen-binding molecules capable of binding to IL-11, and methods of medical treatment and prophylaxis using the same.

Abstract: Methods for the diagnosis, treatment and prophylaxis of fibrosis and/or angiogenesis, in particular in the eye, are disclosed. In particular embodiments, the methods employ antagonism of IL-11 mediated signalling and antagonism of angiogenesis. Also provided are combinations comprising an antagonist of IL-11 mediated signalling and an antagonist of an angiogenic factor.

Abstract: IL-11 antibodies are disclosed. Also disclosed are compositions comprising the IL-11 antibodies, and methods using the IL-11 antibodies.