Abstract: Described is a test device for microneedle systems having a microneedle receptacle for receiving a microneedle system to be tested, an application device, and a movement device including a punch for the application in motion of the microneedle system to be tested in the application device. A test system with a test device of this kind is also described. Lastly, described is a method for testing a microneedle application.

Abstract: A mold element, in particular a casting mold for manufacturing microstructures, in particular microneedle arrays, includes a base body. On an upper side of the base body, several depressions for receiving material for manufacturing the microstructure are provided. In order to improve the quality of the microstructure to be manufactured, in particular during a drying process, channels are provided on the upper side of the base body, each of which is connected to at least one of the depressions.

Abstract: The present invention relates to a microneedle system (MNS) for the intradermal delivery of interferon, wherein polyvinylpyrrolidone is the major constituent of a completely soluble formulation.

Abstract: The present invention relates to a microneedle system (MNS) for the intradermal delivery of interferon, wherein polyvinylpyrrolidone is the major constituent of a completely soluble formulation.

Abstract: A device for producing a patch which includes a plurality of microstructures has at least one die. The die is used to produce a microstructure and has a plurality of depressions for this purpose. Additionally, a support layer, which is provided with an adhesive layer, is provided. In a preferred embodiment, it is possible to move the microstructure formed in the die in the direction of the support layer using a lifting device such that said microstructure adheres to the face of the support layer, which is provided with the adhesive layer. For example, by carrying out a corresponding method multiple times, multiple microstructures can be provided on the support layer adjacently to one another. Optionally, multiple dies can also be provided so that multiple microstructures can be simultaneously arranged on the support layer.

Abstract: An apparatus for producing microarrays includes a die. A plurality of cavities is formed in the die. A cover element is additionally provided in order to cover regions between the cavities. In this manner it is possible to remove an active agent-containing liquid from the regions formed between the cavities when metering said liquid. This is achieved in that the cover element is removed again. An active agent-free liquid can then be metered, with which a remaining portion of the cavities are filled, and a support layer is formed on the upper surface of the die.

Abstract: A carrier element for micro-needles for forming a micro-needle array has a plate-like base element. Mounting elements for respectively connecting to a micro-needle of the micro-needle array are provided on a front side of the base element. Connecting elements are also provided, in particular on the front side of the mounting elements. The connecting elements are formed in such a way that they have an undercut in the longitudinal direction such that the needles are reliably connected to the mounting elements.

Abstract: An applicator for applying a microarray, including a housing, a plunger which is arranged in the housing in a linearly movable manner, a holding device for receiving a microarray device, a pressing element for moving the plunger in order to act on a microarray device received by the holding device, and an actuation device which holds the plunger in a first position and releases the plunger for movement. The plunger is released by the actuation device only when the at least two actuators are actuated. Further, an application system with such an applicator and a microarray device and to a method for displacing a plunger are included. The plunger is held in a first position against a pretension, and the plunger is released for movement by the pretension upon carrying out at least two separate actuations, where the at least two actuations must be carried out for the release process.

Abstract: A support for at least one microarray, with a housing and a punch arranged in a movable manner within the housing. At least one microarray is connected to the punch. The housing includes an application opening for applying the at least one microarray. Further, a method for producing a support for at least one microarray. The method includes the steps of manufacturing a housing with an application opening, manufacturing a punch, connecting a microarray to the punch, and arranging the punch in a movable manner within the housing.

Abstract: The invention relates to an applicator for application of a microarray, comprising a housing (10) in which a plunger (20) is arranged such that it can move linearly. A retainer element (38) is also provided for receiving a microarray (28). A pressure element (34) makes it possible for the plunger (20) to be displaced in order for it to act upon a microarray (28) receive by the retainer element (38). An actuation element (44) allows the plunger (20) to be held in an internal position, and this can be released by actuating said actuation element (44).

Abstract: A device for manufacturing microstructures including a permeable template, wherein the template comprises at least one recess for manufacturing the microstructures. In addition, the device comprises a vacuum-generating device connected to the template such that a vacuum is applied to at least one side of the template. Further, a method for filling a permeable template, wherein the template comprises at least one recess for manufacturing microstructures.

Abstract: The present invention relates to a microneedle system (MNS) for the intradermal delivery of interferon, wherein polyvinylpyrrolidone is the major constituent of a completely soluble formulation.

Abstract: A microneedle system and method for production thereof. From a board a web grating is produced which has a plurality of grating nodes each defined by three apertures and which has web grating wedges. The microneedle system comprising a board and a plurality of openings delimited circumferentially by a web grating, having at each opening at least one web grating wedge having a needle-shaped tip which projects from the board and which is oriented at least approximately normal to the board. Web grating wedges having needle-shaped tips protrude into each aperture from at least three different directions. In order to produce openings, at least all the web grating wedges which protrude into an aperture are bent by a punch and the needle-shaped tips thereof are oriented normal to the plane of the web grating. At least two web grating wedges are arranged at each opening.

Abstract: A single-use injector having a plunger actuator which is mounted in a housing, which is loaded by a spring energy store, and which can be unlocked by a movable release device. The plunger actuator can be supported by a traction rod mounted in the housing. The movable release device includes a casing housing. The casing housing includes an upper shell and a lower shell, the separation line of which is oriented in the longitudinal direction of the single-use injector. The casing housing has a cornerless cross-section deviating from a circular shape. The housing is anti-rotationally centered in the casing housing.

Abstract: A microneedle system and method for production thereof. From a board a web grating is produced which has a plurality of grating nodes each defined by three apertures and which has web grating wedges. The microneedle system comprising a board and a plurality of openings delimited circumferentially by a web grating, having at each opening at least one web grating wedge having a needle-shaped tip which projects from the board and which is oriented at least approximately normal to the board. Web grating wedges having needle-shaped tips protrude into each aperture from at least three different directions. In order to produce openings, at least all the web grating wedges which protrude into an aperture are bent by a punch and the needle-shaped tips thereof are oriented normal to the plane of the web grating. At least two web grating wedges are arranged at each opening.

Abstract: The invention relates to the needle-free subcutaneous administration of proteins to humans and animals by means of a protein delivery device comprising a unit made of a nozzle, a chamber, a piston, an actuating device, and a drive, and a corresponding process and its use.