Abstract: The invention relates to a protective helmet with an outer shell (1) for distributing impact forces, an interior layer (2) accommodated by the outer shell (1) for attenuating impact forces, and a slot (3) for accommodating an electrical device (4), wherein the outer shell (1) has a chin shell area (6) to cover a chin portion of a protective helmet wearer, wherein the outer shell (1) forms a viewing port (8) for the protective helmet wearer to look through. The protective helmet is characterized in that the slot (3) is arranged on the chin shell area (6) in such a way that the accommodated electrical device (4) is arranged between the chin shell area (6) and the interior layer (2), wherein the protective helmet has an interior cover (10) for essentially completely covering the accommodated electrical device (4) in the direction of the viewing port (8).

Abstract: An optical assembly includes a lens unit capable of being moved along an optical axis of the optical assembly. The lens unit includes a lens mount for holding at least one lens. The optical assembly further includes a sleeve for receiving the lens mount. The lens mount is in sliding contact with and movable in relation to the sleeve as the lens unit is moved along the optical axis. The lens mount is formed of or comprises at its outer surface a self-lubricating material, and/or the sleeve is formed of or comprises at its inner surface a self-lubricating material.

Abstract: A method for the use of a cytochrome P450 enzyme comprising any of SEQ ID NO: 1-118, or mutants thereof or a variant enzyme having at least 70% identity thereto and having CYP450 activity, for the hydroxylation and or dealkylation of an organic compound.

Abstract: A maintenance planning system for a production plant comprises: a production planning system for determining a production sequence for the production plant; an automation system for controlling production in the production plant; a state monitoring system for acquiring states of the production plant and its components; and a business planning system for the economic management of production and maintenance in the production plant. The maintenance planning system is designed for determining maintenance measures for the production plant. When determining the maintenance measures, the maintenance planning system takes into account the information of the production planning system, the automation system, the state monitoring system and the business planning system and performs optimization with regard to an economic utilization of the production plant. The disclosure further relates to a method for determining maintenance measures for a production plant and corresponding computer programs.

Abstract: In a system for optimizing production installations and/or processes of a metallurgical installation each production installation and/or process comprises a separate data management device. Entities of the metallurgical installation that are relevant for the respective part of the production installation and/or process are identifiable by local identifiers and the local identifiers can be used to retrieve data of separate data management devices. Within a central data management device each entity of the metallurgical installation has an associated global identifier. The applicable local identifiers of the separate data management devices are associated with the same entities of the metallurgical installation by the respective global identifier in the central data management device. Optimization involves at least some of the data from the separate data management devices being aggregated and evaluated by means of the global identifiers.

Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 110, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound, wherein the amino acid residue at position 291 is not threonine.

Abstract: The present invention relates to a cytochrome P450 enzyme comprising the amino acid sequence set forth in SEQ ID NO: 3, or a variant thereof having an amino acid sequence having at least 95% identity thereto and having CYP450 activity. The cytochrome P450 enzyme provided herein was isolated from Streptomyces eurythermus NRRL 2539 and has a wide substrate range and high activity, and may be used to oxidate organic compounds.

Abstract: A computer-implemented method for generating a synthetic training data set for training a machine learning computer vision model for performing at least one user defined computer vision task, in which spatially resolved sensor data are processed and evaluated with respect to at least one user defined object of interest, including receiving at least one model of a user defined object of interest; determining at least one render parameter and multiple render parameters; generating a set of training images by rendering the at least one model of the object of interest based on the at least one render parameter; generating annotation data for the set of training images with respect to the at least one object of interest; and providing a training data set including the set of training images and the annotation data for being output to the user and/or for training the computer vision model.

Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 3, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound.

Abstract: A method for the use of a cytochrome P450 enzyme comprising any of SEQ ID NO: 1-118, or mutants thereof or a variant enzyme having at least 70% identity thereto and having CYP450 activity, for the hydroxylation and or dealkylation of an organic compound.

Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 110, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound, wherein the amino acid residue at position 291 is not threonine.

Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 3, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound.

Abstract: A method is provided for operating a trace procedure, which traces execution of a computer program, where the program uses different callable modules. A program stack is used to store trace buffer information and an error state, and the modules include calls of the trace procedure. The method includes: (i) when entering execution of a module, storing the current write position of the trace buffer and a cleared error flag in the current frame of the stack; (ii) in case of an error condition during execution of the program, setting the error flag in the current frame; and (iii) when leaving execution of a module, determining if the error flag is set, and if not, then rewinding the trace buffer to the write position stored in the current frame, and deleting the current write position of the trace buffer and the error flag from the stack.

Abstract: A method is provided for operating a trace procedure, which traces execution of a computer program, where the program uses different callable modules. A program stack is used to store trace buffer information and an error state, and the modules include calls of the trace procedure. The method includes: (i) when entering execution of a module, storing the current write position of the trace buffer and a cleared error flag in the current frame of the stack; (ii) in case of an error condition during execution of the program, setting the error flag in the current frame; and (iii) when leaving execution of a module, determining if the error flag is set, and if not, then rewinding the trace buffer to the write position stored in the current frame, and deleting the current write position of the trace buffer and the error flag from the stack.

Abstract: A method is provided for operating a trace procedure, which traces execution of a computer program, where the program uses different callable modules. A program stack is used to store trace buffer information and an error state, and the modules include calls of the trace procedure. The method includes: (i) when entering execution of a module, storing the current write position of the trace buffer and a cleared error flag in the current frame of the stack; (ii) in case of an error condition during execution of the program, setting the error flag in the current frame; and (iii) when leaving execution of a module, determining if the error flag is set, and if not, then rewinding the trace buffer to the write position stored in the current frame, and deleting the current write position of the trace buffer and the error flag from the stack.

Abstract: A method is provided for operating a trace procedure, which traces execution of a computer program, where the program uses different callable modules. A program stack is used to store trace buffer information and an error state, and the modules include calls of the trace procedure. The method includes: (i) when entering execution of a module, storing the current write position of the trace buffer and a cleared error flag in the current frame of the stack; (ii) in case of an error condition during execution of the program, setting the error flag in the current frame; and (iii) when leaving execution of a module, determining if the error flag is set, and if not, then rewinding the trace buffer to the write position stored in the current frame, and deleting the current write position of the trace buffer and the error flag from the stack.

Abstract: A solid propellant gas generator releases a flowing mixture from a solid propellant, separated from a surrounding area, into the surrounding area. The solid propellant gas generator includes a cooling system for cooling the flowing mixture. The cooling system has at least one feed device for feeding a gas from the surrounding area to the flowing mixture in order to mix the flowing mixture prior to entering into the surrounding area with the gas from the surrounding area.

Abstract: A solid propellant gas generator releases a flowing mixture from a solid propellant, separated from a surrounding area, into the surrounding area. The solid propellant gas generator includes a cooling system for cooling the flowing mixture. The cooling system has at least one feed device for feeding a gas from the surrounding area to the flowing mixture in order to mix the flowing mixture prior to entering into the surrounding area with the gas from the surrounding area.

Abstract: A data processing system boots at least one service processor controlling at least one PCIe card in an I/O unit. The data processing system boots a second service processor located in a processor unit, wherein the processor unit and I/O unit are interconnected using functional path conductors, wherein functional path conductors are according to PCIe standard. The data processing system reads location information from the first at least one service processor, wherein the location information is reported for each PCIe card prior to initializing a functional path to the PCIe card. The data processing system sends location information from the second at least one service processor to a system controller. The data processing system initializes the PCIe card and a hub card of the processor unit in order to initialize a functional path and configures the I/O unit by communicating configuration commands over the functional path.

Abstract: A ventriculostomy instrument comprises a ventriculostomy catheter having ultrasound capabilities. The ventriculostomy catheter can include a catheter wall defining a central lumen passageway, and a stylet device removably received in the central lumen passageway. An ultrasound probe is disposed in the catheter wall and remains in place at the distal end of the catheter when the stylet is removed. Thus it may be used to provide substantially continuous ultrasound imaging and monitoring during positioning, during fluid draining or during the insertion of medical instruments into the brain via the central lumen passageway of the catheter.