Patents by Inventor Sebastiano PASQUALATO

Sebastiano PASQUALATO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED TRANSPOSASE AND USES THEREOF
    Publication number: 20240425848
    Abstract: The present invention relates to an engineered transposase comprising a transposase operably linked to a polypeptide that binds to a component of heterochromatin. The present invention further relates to an engineered transposome complex comprising an oligonucleotide and an engineered transposase according to the invention. The present invention also relates to methods and uses of the engineered transposase of the invention and engineered transposome of the invention for making a DNA sequence library or libraries and for DNA sequencing.
    Type: Application
    Filed: July 22, 2022
    Publication date: December 26, 2024
    Inventors: Giovanni Tonon, Davide Cittaro, Martina Tedesco, Francesca Giannese, Dejan Lazarevic, Sebastiano Pasqualato
  • HECT E3 LIGASE INHIBITORS AND USES THEREOF
    Publication number: 20220339163
    Abstract: The present invention relates to tricyclic derivatives of formula (I), which are useful as inhibitors of HECT-domain-containing E3 ligases, in particular NEDD4. The present invention also refers to pharmaceutical compositions comprising compounds of formula (I), to their medical use and to their process of preparation.
    Type: Application
    Filed: June 3, 2020
    Publication date: October 27, 2022
    Applicants: IFOM - FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE, IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L.
    Inventors: Sebastiano PASQUALATO, Maurizio PASI, Raffaella AMICI, Mario VARASI, Ciro MERCURIO, Luca SARTORI, Simona POLO, Elena MASPERO, Giovanni FAGA'