Abstract: Certain embodiments of the present invention provide a system for controlling temperatures in an x-ray imaging environment including: a first component capable of operating within a first temperature range; a second component capable of operating within a second temperature range; and a liquid-based temperature control system capable of maintaining the first component within the first temperature range and maintaining the second component within the second temperature range. In an embodiment, the first component includes an x-ray detector. In an embodiment, the second component includes an x-ray source. In an embodiment, a liquid in the liquid-based temperature control system flows through the first component before flowing through the second component. In an embodiment, a heat exchanger in the liquid-based temperature control system can regulate a temperature of a liquid in the liquid-based temperature control system. In an embodiment, the heat exchanger includes at least one thermoelectric cooler device.