Patents by Inventor Sebastien Harlepp

Sebastien Harlepp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Total internal reflection fluorescence apparatus
    Patent number: 7330255
    Abstract: Techniques are provided for illuminating a sample by using total internal reflection (TIR) from a diffraction limited focused annular illumination beam. The illumination forms an affected region and an overlapping confocal region that may have dimensions the below 1 ?m. An adjustable diffractive optical element, for example, may create a second order Bessel profile laser beam that is focused on a sample using a high-numerical aperture objective under TIR. An evanescent field excites fluorescent biological material in the confocal region, and fluorescence from the material is analyzed in fluorescence correlation spectroscopy system.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: February 12, 2008
    Assignee: University of Chicago
    Inventors: Philippe Cluzel, Sebastien Harlepp
  • Total internal reflection fluorescence apparatus
    Publication number: 20060126063
    Abstract: Techniques are provided for illuminating a sample by using total internal reflection (TIR) from a diffraction limited focused annular illumination beam. The illumination forms an affected region and an overlapping confocal region that may have dimensions the below 1 ?m. An adjustable diffractive optical element, for example, may create a second order Bessel profile laser beam that is focused on a sample using a high-numerical aperture objective under TIR. An evanescent field excites fluorescent biological material in the confocal region, and fluorescence from the material is analyzed in fluorescence correlation spectroscopy system.
    Type: Application
    Filed: December 9, 2004
    Publication date: June 15, 2006
    Inventors: Philippe Cluzel, Sebastien Harlepp