Abstract: A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for environment simulation. In one aspect, a system comprises a recurrent neural network configured to, at each of a plurality of time steps, receive a preceding action for a preceding time step, update a preceding initial hidden state of the recurrent neural network from the preceding time step using the preceding action, update a preceding cell state of the recurrent neural network from the preceding time step using at least the initial hidden state for the time step, and determine a final hidden state for the time step using the cell state for the time step. The system further comprises a decoder neural network configured to receive the final hidden state for the time step and process the final hidden state to generate a predicted observation characterizing a predicted state of the environment at the time step.

Abstract: A neural network system is proposed. The neural network can be trained by model-based reinforcement learning to select actions to be performed by an agent interacting with an environment, to perform a task in an attempt to achieve a specified result. The system may comprise at least one imagination core which receives a current observation characterizing a current state of the environment, and optionally historical observations, and which includes a model of the environment. The imagination core may be configured to output trajectory data in response to the current observation, and/or historical observations. The trajectory data comprising a sequence of future features of the environment imagined by the imagination core. The system may also include a rollout encoder to encode the features, and an output stage to receive data derived from the rollout embedding and to output action policy data for identifying an action based on the current observation.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for environment simulation. In one aspect, a system comprises a recurrent neural network configured to, at each of a plurality of time steps, receive a preceding action for a preceding time step, update a preceding initial hidden state of the recurrent neural network from the preceding time step using the preceding action, update a preceding cell state of the recurrent neural network from the preceding time step using at least the initial hidden state for the time step, and determine a final hidden state for the time step using the cell state for the time step. The system further comprises a decoder neural network configured to receive the final hidden state for the time step and process the final hidden state to generate a predicted observation characterizing a predicted state of the environment at the time step.

Abstract: Disclosed is a sensor measuring patient spine vertebra angular orientation, including: a fastener, adapted to be fastened on a specific patient spine vertebra in a unique orientation relative to the specific vertebra, a support, solidary with the fastener in a unique orientation relative to the fastener, a detector, removably secured to the support in a unique orientation relative to the support and adapted to measure one or more parameters representative of the patient spine vertebra angular orientation.

Abstract: A method for visualizing patient dentition acquires a contour image of patient dentition and segments the contour image to identify one or more segmented teeth. At least one deciduous tooth among the one or more segmented teeth is identified. A virtual model of a target dentition arrangement of the patient dentition is generated, wherein the at least one deciduous tooth is replaced by a replacement permanent tooth.

Abstract: A neural network system is proposed. The neural network can be trained by model-based reinforcement learning to select actions to be performed by an agent interacting with an environment, to perform a task in an attempt to achieve a specified result. The system may comprise at least one imagination core which receives a current observation characterizing a current state of the environment, and optionally historical observations, and which includes a model of the environment. The imagination core may be configured to output trajectory data in response to the current observation, and/or historical observations. The trajectory data comprising a sequence of future features of the environment imagined by the imagination core. The system may also include a rollout encoder to encode the features, and an output stage to receive data derived from the rollout embedding and to output action policy data for identifying an action based on the current observation.

Abstract: A neural network system is proposed to select actions to be performed by an agent interacting with an environment to perform a task in an attempt to achieve a specified result. The system may include a controller to receive state data and context data, and to output action data. The system may also include an imagination module to receive the state and action data, and to output consequent state data. The system may also include a manager to receive the state data and the context data, and to output route data which defines whether the system is to execute an action or to imagine. The system may also include a memory to store the context data.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for environment simulation. In one aspect, a system comprises a recurrent neural network configured to, at each of a plurality of time steps, receive a preceding action for a preceding time step, update a preceding initial hidden state of the recurrent neural network from the preceding time step using the preceding action, update a preceding cell state of the recurrent neural network from the preceding time step using at least the initial hidden state for the time step, and determine a final hidden state for the time step using the cell state for the time step. The system further comprises a decoder neural network configured to receive the final hidden state for the time step and process the final hidden state to generate a predicted observation characterizing a predicted state of the environment at the time step.

Abstract: Microneedle patches and systems, and methods for use of such patches and systems. In one aspect, a microneedle patch is provided including a tab portion for handling the microneedle patch. In another aspect, a system is provided including a microneedle patch and a tray for housing the microneedle patch. In still another aspect, various indicators providing for providing feedback prior to, during, and after administration of the microneedle patch are provided. Advantageously, the described microneedle patches and systems provide improved handling and ease of application of the microneedle patches to skin for the delivery of therapeutic agents.

Abstract: A method for generating a dental arch map for a patient acquires a 3D surface image of patient dentition and automatically segments the 3D surface image to identify individual teeth. A mapping of outlines is formed for the identified teeth. The mapping is labeled according to a tooth numbering scheme and the labeled mapping is displayed.

Abstract: Methods, systems, and devices are described that provide for D2D synchronization. The methods, systems, and/or devices may include tools and techniques that provide for synchronizing a mobile device based on detection of a reliability alarm. A reliability alarm may be used between mobile devices, which is transmitted and/or received on specific D2D resources. Since the resources are reserved for the reliability alarm, a mobile device which was previously isolated from network synchronization will be able to receive the reliability alarm that a reliable synchronization signal is close when it moves within range of a reliable device. Once a reliability alarm is received the mobile device may free other resources to allow it to receive synchronization signals from the reliable devices. The mobile device may then synchronize with the network based on the received synchronization signals and transmit its own reliability alarm for subsequent isolated devices to use.

Abstract: A method, an apparatus, and a computer program product for wireless communication are provided in connection with enabling timing source selection and deselection in a decentralized manner for distributed D2D synchronization in densely populated communications systems. In an example, a communications device, functioning in a non-timing source (TS) mode, is equipped to receive a request for timing information during a synchronization channel. The communications device may further be equipped to determine whether to switch to a TS mode based on a selection utility metric value. In another example, a communications device, functioning in a TS mode, is equipped to transmit a TIB during a synchronization channel, and determine whether to switch to a non-TS mode based on a deselection utility metric value. In the TS mode, the UE is configured to transmit a TIB, while in the non-TS mode the UE is configured not to transmit the TIB.

Abstract: A method, an apparatus, and a computer program product for wireless communication are provided in connection with improving resource allocation for distributed D2D synchronization in densely populated communications systems. In an example, a communications device is equipped to transmit a synchronization signal during a beacon period of a synchronization channel. In an aspect, the synchronization channel may include the beacon period, a paging period, and a TIB period. The communications device may further be equipped to monitor at least one of the beacon period, the paging period, or the TIB period of the synchronization channel for one or more signals from one or more UEs in a D2D network, and determine whether to transmit information during at least one of the beacon period, the paging period, or the TIB period based at least in part on the monitoring.

Abstract: Methods, systems, and devices are described that provide for D2D synchronization. The methods, systems, and/or devices may include tools and techniques that provide for synchronizing a mobile device based on detection of a reliability alarm. A reliability alarm may be used between mobile devices, which is transmitted and/or received on specific D2D resources. Since the resources are reserved for the reliability alarm, a mobile device which was previously isolated from network synchronization will be able to receive the reliability alarm that a reliable synchronization signal is close when it moves within range of a reliable device. Once a reliability alarm is received the mobile device may free other resources to allow it to receive synchronization signals from the reliable devices. The mobile device may then synchronize with the network based on the received synchronization signals and transmit its own reliability alarm for subsequent isolated devices to use.

Abstract: The invention relates to a transparent glass substrate including at least one glass sheet provided with a thin-film multilayer coating acting on solar radiation, having a light transmission of greater than 10% and an emissivity of less than 50% after a heat treatment, such as a bending or toughening treatment, characterized in that said multilayer coating includes: a niobium Nb functional layer with a thickness of between about 5 nm and about 35 nm; and at least one layer of another material, chosen from the group formed by Ti, Mo, B, Al or an alloy comprising at least one of these elements, which is placed relative to the glass substrate above the functional layer, said layer having a thickness of between about 1 nm and about 5 nm. The invention also relates to monolithic glazing or double glazing incorporating such a substrate.

Abstract: A method, an apparatus, and a computer program product for wireless communication are provided in connection with enabling timing source selection and deselection in a decentralized manner for distributed D2D synchronization in densely populated communications systems. In an example, a communications device, functioning in a non-timing source (TS) mode, is equipped to receive a request for timing information during a synchronization channel. The communications device may further be equipped to determine whether to switch to a TS mode based on a selection utility metric value. In another example, a communications device, functioning in a TS mode, is equipped to transmit a TIB during a synchronization channel, and determine whether to switch to a non-TS mode based on a deselection utility metric value. In the TS mode, the UE is configured to transmit a TIB, while in the non-TS mode the UE is configured not to transmit the TIB.

Abstract: A method, an apparatus, and a computer program product for wireless communication are provided in connection with improving resource allocation for distributed D2D synchronization in densely populated communications systems. In an example, a communications device is equipped to transmit a synchronization signal during a beacon period of a synchronization channel. In an aspect, the synchronization channel may include the beacon period, a paging period, and a TIB period. The communications device may further be equipped to monitor at least one of the beacon period, the paging period, or the TIB period of the synchronization channel for one or more signals from one or more UEs in a D2D network, and determine whether to transmit information during at least one of the beacon period, the paging period, or the TIB period based at least in part on the monitoring.

Abstract: A method, an apparatus, and a computer program product for wireless communication are provided in connection with improving convergence to a common timing structure for devices in a distributed synchronization D2D network. In an example, a communications device is equipped to detect, by a UE, a synchronization signal during a listening slot duration scan of a communication channel. In an aspect, the listening slot duration may be defined based on a first timing structure, and the synchronization signal may be defined based on a second timing structure. The communications device may further be equipped to obtain timing information associated with the second timing structure from the synchronization signal, and determine whether the first timing structure or the second timing structure is a preferred timing structure.

Abstract: The present invention provides composite implants for the replacement or augmentation of non-load bearing or load bearing soft tissues, and methods of making and using these implant compositions. In one embodiment, a composite implant of the present invention comprises a soft polymeric component coupled to a porous polymeric substrate.