Patents by Inventor Sebastien HOFFMANN

Sebastien HOFFMANN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRIAZOLE DERIVATIVES, INTERMEDIATES THEREOF AND THEIR USE AS FUNGICIDES
    Publication number: 20200008427
    Abstract: The present invention relates to novel triazole derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators.
    Type: Application
    Filed: September 18, 2019
    Publication date: January 9, 2020
    Inventors: Sebastien HOFFMANN, Alexander SUDAU, Peter DAHMEN, Ulrike WACHENDORFFF-NEUMANN, Ruth MEISSNER, Julie GEIST, David BERNIER, Jean-Pierre VORS, Pierre-Yves COQUERON, Sven WITTROCK, Ricarda MILLER, Sebastien NAUD, Stephane BRUNET, Pierre GENIX, Phillippe KENNEL
  • Signature for the diagnosis of lung cancer aggressiveness and genetic instability
    Patent number: 9790556
    Abstract: The present invention relates to a method for diagnosing aggressiveness of a lung cancer in a patient from a lung cancer sample of the patient, comprising: a) detecting in vitro an expression profile of the DNA replication stress signature, the signature comprising the CDC6, CLASPIN, PLK1, and POLQ genes, as well as, optionally, RAD51; b) comparing the the expression profile to a reference expression profile, and d) diagnosing cancer aggressiveness from the comparison. Dedicated microarrays and kits are also described, as well as a method of selecting or adapting a suitable treatment.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: October 17, 2017
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Christophe Cazaux, Jean-Sébastien Hoffmann
  • SIGNATURE FOR THE DIAGNOSIS OF LUNG CANCER AGGRESSIVENESS AND GENETIC INSTABILITY
    Publication number: 20140378338
    Abstract: The present invention relates to a method for diagnosing aggressiveness of a lung cancer in a patient from a lung cancer sample of said patient, comprising: a) detecting in vitro an expression profile of the DNA replication stress signature, said signature comprising the CDC6, CLASPIN, PLK1, and POLQ genes, as well as, optionally, RAD51; b) comparing the said expression profile to a reference expression profile, and d) diagnosing cancer aggressiveness and from the said comparison. Dedicated microarrays and kits are also described, as well as a method of selecting or adapting a suitable treatment.
    Type: Application
    Filed: January 7, 2013
    Publication date: December 25, 2014
    Inventors: Christophe Cazaux, Jean-Sébastien Hoffmann
  • Signature for the diagnosis of cancer aggressiveness and genetic instability
    Patent number: 8865408
    Abstract: The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a cancer in a patient from a cancer sample of the patient. The method includes measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in the patient cancer sample, calculating an expression level ratio of the expression level of POLQ to the expression of the control gene in the patient cancer sample, comparing the expression level ratio to a corresponding threshold value, and diagnosing cancer aggressiveness and genetic instability if the POLQ expression level ratio is superior to a corresponding threshold value. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: October 21, 2014
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Paul Sabatier Toulouse III, Institut Claudius Regaud
    Inventors: Christophe Cazaux, Jean-Sébastien Hoffmann, Jean-Christophe Bourdon, Alice Machado Da Silva, Henri Roche
  • SIGNATURE FOR THE DIAGNOSIS OF CANCER AGGRESSIVENESS AND GENETIC INSTABILITY
    Publication number: 20120021935
    Abstract: The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a cancer in a patient from a cancer sample of said patient, comprising: a) measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in said patient cancer sample; b) calculating for said POLQ gene an expression level ratio of the expression level of POLQ to the expression of the said control gene in said patient cancer sample; c) comparing the said POLQ expression level ratio to a corresponding threshold value, and d) diagnosing cancer aggressiveness and genetic instability if the said POLQ expression level ratio is superior to a corresponding threshold values. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment.
    Type: Application
    Filed: May 18, 2011
    Publication date: January 26, 2012
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT CLAUDIUS REGAUD, UNIVERSITE PAUL SABATIER TOULOUSE III
    Inventors: Christophe CAZAUX, Jean-Sébastien HOFFMANN, Jean-Christophe BOURDON, Alice MACHADO DA SILVA, Henri ROCHE
  • Use of mutagenic DNA polymerase for producing random mutations
    Patent number: 7670809
    Abstract: The invention concerns a method for random mutagenesis comprising the replication of a DNA sequence in the presence of an efficient amount of at least a mutase, for example a Pol ?, the random mutagenesis rate being at least of the order of 1 mutation for 400 base pairs. The replication product, optionally recombined and amplified, is cloned in an expression vector so as to generate mutated polypeptides which will be selected on the basis of the desired property or properties.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: March 2, 2010
    Assignee: Millegen
    Inventors: Christophe Cazaux, Jean Sébastien Hoffmann, Thierry Louat, Laurence Servant, Khalil Bouayadi, Hakim Kharrat
  • Use of mutagenic dna polymerase for producing random mutations
    Publication number: 20040110294
    Abstract: The invention concerns a method for random mutagenesis comprising the replication of a DNA sequence in the presence of an efficient amount of at least a mutase, for example a Pol &bgr;, the random mutagenesis rate being at least of the order of 1 mutation for 400 base pairs. The replication product, optionally recombined and amplified, is cloned in an expression vector so as to generate mutated polypeptides which will be selected on the basis of the desired property or properties.
    Type: Application
    Filed: October 22, 2003
    Publication date: June 10, 2004
    Inventors: Khalil Bouayadi, Hakim Kharrat, Thierry Louat, Laurence Servant, Christophe Cazaux, Jean Sebastien Hoffmann
  • Use of a vector expressing DNA polymerase &bgr; as medicine
    Patent number: 6475996
    Abstract: The invention concerns the use of a vector expressing DNA polymerase &bgr; for the treatment of cancer or viral diseases such as AIDS.
    Type: Grant
    Filed: July 6, 1999
    Date of Patent: November 5, 2002
    Assignee: Centre National De La Recherche Scientifique (CNRS)
    Inventors: Christophe Cazaux, Gérard Jean Tiraby, Pascal Fons, Jean-Sébastien Hoffmann