Abstract: Implantable medical devices include a substrate having applied thereto a coating including a polymeric material possessing a core and at least one functional group known to have click reactivity.

Abstract: The present invention relates to an implant comprising: a sheet of bacterial cellulose having a macro-pattern positioned on at least a portion thereof. The invention also relates to a method for making such an implant.

Abstract: The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.

Abstract: Enzymatically degradable compositions containing biocompatible polymers reactive with glycosaminoglycan compositions having a first glycosaminoglycan having a first degree of acetylation and a second glycosaminoglycan having a second degree acetylation different than the first degree of acetylation.

Abstract: The present disclosure relates to an apparatus and process for forming medical devices from an injectable composition. The apparatus includes a supply assembly configured to maintain and selective dispense a first precursor and a second precursor, a mixing assembly configured to mix the first and second precursors, and at least one catalyzing element including a transition metal ion to aid in the polymerization of the first and second precursors. The process includes dispensing a volume of the first precursor and a volume of the second precursor into a mixing assembly and mixing the first and second precursors. The first and second precursors each possess a core and at least one functional group known to have click reactivity with each other. The mixed precursors are contacted with a transition metal catalyst to produce a flowable composition for use as a medical device.

Abstract: The present invention relates to A bioresorbable implant comprising: a bioresorbable porous layer including a biopolymer foam and defining first pores, a bioresorbable porous three-dimensional mesh made from a microbial cellulose and defining second pores, wherein the bioresorbable porous layer is disposed in the bioresorbable porous three-dimensional mesh. The invention also relates to a method of making a bioresorbable implant.

Abstract: The present invention relates to a process for preparing a porous layer of biocompatible polymer, having a uniform density and porosity, comprising the following steps: —a) a quantity Qp of solution of the said polymer, having a viscosity Vp, is poured into a mould in order to form a first sublayer, the surface of the first sublayer being left to the open air; —b) a quantity Qs of solvent, having a viscosity Vs, lower than Vp, is spread uniformly over the surface of the first sublayer so as to form a second sublayer; —c) the first and second sublayers are subjected to a step of lyophilisation, in which the said polymer is a polysaccharide chosen from hyaluronic acid, alginic acid and chitosan, salts thereof and mixtures thereof.

Abstract: The present invention relates to an implant comprising: a sheet of bacterial cellulose having a macro-pattern positioned on at least a portion thereof. The invention also relates to a method for making such an implant.

Abstract: The present invention relates to a method for the preparation of chitosan of a degree of acetylation DAr, from chitosan ? having a degree of acetylation DAi lower than DAr, comprising at least one step of purification and at least one step of acetylation of said chitosan ?, said purification step comprising at least one step of solubilization of said chitosan ? in an acidic aqueous medium and at least one step of precipitation of said thus solubilized chitosan, wherein said acetylation step is carried out in a solution on said solubilized chitosan before said precipitation step.

Abstract: Method for preparing a chitosan-based porous layer The present invention relates to a method or preparing a chitosan-based, neutralized compressed porous layer, comprising the following steps: —a) a chitosan solution is prepared, —b) said solution is poured into a mould in order to form a layer, —c) the layer obtained in b) is lyophilized so as to obtain a porous layer, —d) said porous layer obtained in c) is compressed, —e) the compressed porous layer obtained in d) is neutralized by means of an NH4OH solution. It also relates to an implant comprising a layer obtained according to such a method.

Abstract: Mono- and multi-layered implants include at least one porous layer made from a freeze dried aqueous solution containing chitosan, the solution having a pH of less than about 5.

Abstract: A bioadherent composition includes a first mixture containing a plurality of reactive members of a specific binding pair, said reactive members being bound to a ligand capable of binding a receptor on biological tissue, and a second mixture containing a plurality of complementary reactive members of the specific binding pair, said complementary reactive members being bound to a ligand capable of binding a receptor on biological tissue, said reactive members capable of forming covalent bonds with said complementary reactive members via a reaction selected from Huisgen cycloaddition reactions, Diels-Alder reactions, and/or thiol-alkene reactions. A method for bonding biological tissue involves utilizing the bioadherent composition.

Abstract: The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.

Abstract: The invention relates to a disposable flexible membrane (1) suitable for adhesion to an objective lens, especially an objective of a camera for laparoscopic operations, the membrane (1) being transparent and comprising two opposite faces, a first face (4) comprising a hydrophobic surface, and a second face (6) comprising a surface of reversible adhesiveness. The invention further relates to a method for temporarily protecting the objective lens of a camera comprising the step of manually positioning such a membrane onto said lens and further manually removing said membrane from said lens.

Abstract: The present disclosure relates to an apparatus and process for forming medical devices from an injectable composition. The apparatus includes a supply assembly configured to maintain and selective dispense a first precursor and a second precursor, a mixing assembly configured to mix the first and second precursors, and at least one catalyzing element including a transition metal ion to aid in the polymerization of the first and second precursors. The process includes dispensing a volume of the first precursor and a volume of the second precursor into a mixing assembly and mixing the first and second precursors. The first and second precursors each possess a core and at least one functional group known to have click reactivity with each other. The mixed precursors are contacted with a transition metal catalyst to produce a flowable composition for use as a medical device.

Abstract: The present invention relates to a composite implant comprising: a prosthetic fabric having a first side and a second side, a non-porous film of bacterial cellulose secured to the first side of the fabric. The invention further relates to a method of making such an implant.

Abstract: The present invention relates to a prosthesis (200) comprising:—at least one layer of a flexible mesh (1) delimited by a peripheral outer edge (1a), said mesh having a first colour, and—at least one layer (2) of porous material fixed to said mesh substantially along the perimeter of said peripheral outer edge, said layer of porous material being recessed at its central part (4), said layer of porous material having a second colour, different from said first colour.

Abstract: The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.

Abstract: A bioadherent composition includes a first mixture containing a plurality of reactive members of a specific binding pair, said reactive members being bound to a ligand capable of binding a receptor on biological tissue, and a second mixture containing a plurality of complementary reactive members of the specific binding pair, said complementary reactive members being bound to a ligand capable of binding a receptor on biological tissue, said reactive members capable of forming covalent bonds with said complementary reactive members via a reaction selected from Huisgen cycloaddition reactions, Diels-Alder reactions, and/or thiol-alkene reactions. A method for bonding biological tissue involves utilizing the bioadherent composition.

Abstract: The present disclosure provides mono- and multi-layered implants which include at least one porous layer made from a freeze-dried aqueous solution containing chitosan, the solution having a pH of less than about 5.