Patents by Inventor Sebastien Rose

Sebastien Rose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of and crystalline forms of optical enantiomers of modafinil
    Patent number: 9382200
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 8.54, 4.56, and 3.78 ?, and a process for the preparation thereof.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: July 5, 2016
    Assignee: Teva Sante
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stéphanie Graf, Gilles Serrure, Gérard Francois Coquerel, Sébastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde
  • Method for purifying a fused pyrrolocarbazole derivative
    Patent number: 8884014
    Abstract: The present invention relates a method for purifying a fused pyrrolocarbazole compound known as 11-isobutyl-2-methyl-8-(2-pyrimidinylamino)-2,5,6,11,12,13-hexahydro-4Hindazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one using an acid complex thereof. The present invention also relates to a crystalline form of the acid complex.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: November 11, 2014
    Assignees: Cephalon, Inc., Teva Sante
    Inventors: Shawn P. Allwein, Arnaud Grandeury, Guy Piacenza, Sebastien Rose
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20100048718
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 5.23, 5.03, 4.22 and 4.10 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: February 25, 2010
    Applicant: Cephalon France
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stephanie Graf, Gilles Serrure, Gerard Francois Coquerel, Sebastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20100048719
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 12.31, 8.54, 7.27 and 3.62 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: February 25, 2010
    Applicant: Cephalon France
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stephanie Graf, Gilles Serrure, Gerard Francois Coquerel, Sebastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20100048720
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 14.14, 10.66, 7.80 and 4.02 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: February 25, 2010
    Applicant: Cephalon France
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stéphanie Graf, Gilles Serrure, Gérard Fransois Coquerel, Sébastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20100022653
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 8.54, 4.56, and 3.78 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: January 28, 2010
    Applicant: Cephalon France
    Inventors: Olivier NECKEBROCK, Laurent COURVOISIER, Stéphanie GRAF, Gilles SERRURE, Gérard Francois COQUEREL, Sébastien ROSE, Christine BESSELIEVRE, Franck Patrick MALLET, Adriaan Jan VAN LANGEVELDE
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20090281192
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 12.38, 8.58, 7.34, 5.00 and 4.09 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: November 12, 2009
    Applicant: Cephalon France
    Inventors: Olivier NECKEBROCK, Laurent COURVOISIER, Stéphanie GRAF, Gilles SERRURE, Gérard Francois COQUEREL, Sébastien ROSE, Christine BESSELIEVRE, Franck Patrick MALLET, Adriaan Jan VAN LAGEVELDE
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20090281193
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 9.45, 7.15, 5.13, 4.15 and 3.67 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: November 12, 2009
    Applicant: Cephalon France
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stephanie Graf, Gilles Serrure, Gérard François Coquerel, Sébastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde
  • Modafinil synthesis process
    Patent number: 7541493
    Abstract: The invention relates to a process for preparing modafinil having a defined granulometry which comprises the steps of: a) preparing a solution of DMSAM; b) contacting the solution obtained with NH3 at a predetermined temperature and a predetermined stirring; and c) isolating the modafinil formed, wherein said temperature and said stirring are predetermined in order to obtain said defined granulometry.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: June 2, 2009
    Assignee: Cephalon France
    Inventor: Sébastien Rose
  • Method for preparing methyl 2-diphenylmethylsulfinylacetate
    Patent number: 7211684
    Abstract: The invention relates to a method for preparing methyl 2-diphenylmethylsulfinylacetate (MDMSA) comprising the steps of: (i) conversion of benzhydrol into methyldiphenylmethylthioacetate (MDMTA); and (ii) conversion of methyldiphenylmethylthioacetate (MDMTA) into methyl-2-diphenylmethylsulfinylacetate by oxidation, according to the following sequence: benzhydrol?MDMTA?MDMSA.
    Type: Grant
    Filed: January 8, 2004
    Date of Patent: May 1, 2007
    Assignee: Cephalon France
    Inventors: Sébastien Rose, Dominique Klein
  • Process for the preparation of and crystalline forms of optical enantiomers of modafinil
    Publication number: 20060241320
    Abstract: The invention relates to a process for the preparation of crystalline forms of the optical enantiomers of modafinil, comprising stages comprising: i) dissolving one of the optical enantiomers of modafinil in a solvent other than ethanol, ii) crystallising the modafinil enantiomer, iii) recovering the crystalline form of the modafinil enantiomer so obtained. The invention also relates to a process for the preparation of the optical enantiomers of modafinil.
    Type: Application
    Filed: June 26, 2006
    Publication date: October 26, 2006
    Applicants: Cephalon France, Organisation De Synthese Mondiale Orsymonde
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stephanie Graf, Gilles Serrure, Gerard Francois Coquerel, Sebastien Rose, Christine Besselievre, Franck Mallet, Adriaan Van Langevelde
  • Method for preparing methyl 2-diphenylmethylsulfinylacetate
    Publication number: 20060235237
    Abstract: Method for preparing methyl 2-diphenylmethylsulfinylacetate (MDMSA) comprising the steps of: (i) conversion of benzhydrol into methyldiphenylmethylthio-acetate; and (ii) conversion of methyldiphenylmethylthioacetate into methyl-2-diphenylmethylsulfinylacetate by oxidation.
    Type: Application
    Filed: January 8, 2004
    Publication date: October 19, 2006
    Inventors: Sebastien Rose, Dominique Klein
  • Method for the production of crystalline forms and crystalline forms of optical enantiomers of modafinil
    Publication number: 20060135621
    Abstract: The invention relates to a process for the preparation of crystalline forms of the optical enantiomers of modafinil, comprising stages comprising: i) dissolving one of the optical enantiomers of modafinil in a solvent other than ethanol, ii) crystallising the modafinil enantiomer, iii) recovering the crystalline form of the modafinil enantiomer so obtained. The invention also relates to a process for the preparation of the optical enantiomers of modafinil.
    Type: Application
    Filed: December 18, 2003
    Publication date: June 22, 2006
    Applicants: Cephalon France, Organisation De Synthese Mondiale Orsymonde
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stephanie Graf, Gilles Serrure, Gerard Coquerel, Sebastien Rose, Christine Besselievre, Franck Mallet, Adriaan Van Langevelde