Patents by Inventor Seemon H. Pines

Seemon H. Pines has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal forms of anamorelin
    Patent number: 9975921
    Abstract: Crystalline forms of anamorelin which are useful as pharmaceutical agents are disclosed. Methods of production and isolation of these polymorphs and pharmaceutical compositions which include these polymorphs and pharmaceutical methods of treatment are also disclosed. The crystalline polymorphs of the present invention are useful as they act directly on the pituitary gland cells to release growth hormone.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: May 22, 2018
    Assignee: HELSINN HEALTHCARE SA
    Inventors: Keith Lorimer, Seemon H Pines, Bernhard Paul, Benjamin Littler
  • Crystal Forms of Anamorelin
    Publication number: 20160046667
    Abstract: Crystalline forms of anamorelin which are useful as pharmaceutical agents are disclosed. Methods of production and isolation of these polymorphs and pharmaceutical compositions which include these polymorphs and pharmaceutical methods of treatment are also disclosed. The crystalline polymorphs of the present invention are useful as they act directly on the pituitary gland cells to release growth hormone.
    Type: Application
    Filed: October 30, 2015
    Publication date: February 18, 2016
    Inventors: Keith Lorimer, Seemon H. Pines, Bernhard Paul, Benjamin Littler
  • Crystal forms of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide
    Patent number: 8466173
    Abstract: Crystalline polymorphs of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide which are useful as pharmaceutical agents are disclosed. Methods of production and isolation of these polymorphs and pharmaceutical compositions which include these polymorphs and pharmaceutical methods of treatment are also disclosed. The crystalline polymorphs of the present invention are useful as they act directly on the pituitary gland cells to release growth hormone.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: June 18, 2013
    Assignee: Helsinn Therapeutics (U.S.), Inc.
    Inventors: Keith Lorimer, Seemon H. Pines, Paul Bernhard, Benjamin Littler
  • Crystal Forms of (3R)-1-(2-Methylalanyl-D-Tryptophyl)-3-(Phenylmethyl)-3-Piperidinecarboxylic Acid 1,2,2-Trimethylhydrazide
    Publication number: 20110003996
    Abstract: Crystalline polymorphs of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide which are useful as pharmaceutical agents are disclosed. Methods of production and isolation of these polymorphs and pharmaceutical compositions which include these polymorphs and pharmaceutical methods of treatment are also disclosed. The crystalline polymorphs of the present invention are useful as they act directly on the pituitary gland cells to release growth hormone.
    Type: Application
    Filed: July 6, 2010
    Publication date: January 6, 2011
    Applicant: Helsinn Therapeutics (U.S.), Inc.
    Inventors: Keith Lorimer, Seemon H. Pines, Bernhard Paul, Benjamin Littler
  • Crystal forms of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide
    Patent number: 7825138
    Abstract: Crystalline polymorphs of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide which are useful as pharmaceutical agents are disclosed. Methods of production and isolation of these polymorphs and pharmaceutical compositions which include these polymorphs and pharmaceutical methods of treatment are also disclosed. The crystalline polymorphs of the present invention are useful as they act directly on the pituitary gland cells to release growth hormone.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: November 2, 2010
    Assignee: Helsinn Therapeutics (U.S.), Inc.
    Inventors: Keith Lorimer, Seemon H. Pines, Bernhard Paul, Benjamin Littler
  • Trifluoromethylbenzyl containing quaternary salts
    Patent number: 5093498
    Abstract: A process is disclosed for obtaining manipulated proportions of the (+) and (-) enantiomers of [(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]aceti c acid by asymmetric chiral phase transfer catalysis.
    Type: Grant
    Filed: June 28, 1991
    Date of Patent: March 3, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Ulf H. Dolling, Seemon H. Pines, Edward J. J. Grabowski
  • Process for preparing a manipulated enantiomer mixture by asymmetric chiral phase transfer catalysis
    Patent number: 4578509
    Abstract: A process is disclosed for obtaining manipulated proportions of the (+) and (-) enantiomers of [(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]aceti c acid by asymmetric chiral phase transfer catalysis.
    Type: Grant
    Filed: February 17, 1984
    Date of Patent: March 25, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Ulf H. Dolling, Seemon H. Pines, Edward J. J. Grabowski
  • Process for preparing methylvanillyl ketone from isoeugenol
    Patent number: 4273943
    Abstract: Methylvanillyl ketone is prepared from a "through process" involving oxidation of isoeugenol followed by subsequent acidic hydrolysis.
    Type: Grant
    Filed: September 28, 1979
    Date of Patent: June 16, 1981
    Assignee: Merck & Co., Inc.
    Inventors: George Gal, Seemon H. Pines
  • Preparation of hydroxyphenylalanine hydrohalide salts
    Patent number: 4230883
    Abstract: The invention relates to the hydrohalide salts of L-.alpha. -methyl-3,4-dihydroxyphenylalanine (methydopa). The method of preparing these and related compounds in the absence of water or other polar solvents is also shown.
    Type: Grant
    Filed: December 12, 1977
    Date of Patent: October 28, 1980
    Assignee: Merck & Co., Inc.
    Inventors: David D. Saperstein, Seemon H. Pines
  • Process for preparing a ketone
    Patent number: 4169858
    Abstract: A process for preparing methyl vanillyl ketone from guaiacol is disclosed.
    Type: Grant
    Filed: March 6, 1978
    Date of Patent: October 2, 1979
    Assignee: Merck & Co., Inc.
    Inventors: George Gal, Seemon H. Pines
  • Caustic washed molecular sieves
    Patent number: 4134965
    Abstract: A novel improved molecular sieve is prepared by a caustic wash process. The sieves so prepared show improved properties in reactions involving e.g., superior acid scavenging ability.
    Type: Grant
    Filed: August 31, 1977
    Date of Patent: January 16, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Alan J. Rein, David D. Saperstein, Seemon H. Pines
  • Preparation of 3-hydroxymethyl-7.beta.-aminoadipoyl-7.alpha.-methoxy-3-cephem-4-carboxy lic acid
    Patent number: 4031085
    Abstract: This invention relates to the preparation of 3-hydroxymethyl-7.beta.-aminoadipoyl-7.alpha.-methoxy-3-cephem-4-carboxyli c acid from 3-(.alpha.-methoxy-p-sulfo-oxycinnamoyloxymethyl)-7.beta.-aminoadipoyl-7.a lpha.-methoxy-3-cephem-4-carboxylic acid or 3-(.alpha.-methoxy-p-hydroxycinnamoyloxymethyl)-7.beta.-aminoadipoyl-7.alp ha.-methoxy-3-cephem-4-carboxylic acid by treatment at 60.degree. C. and pH 3.5-6.5 for about 1 hour. The starting compounds are isolated as fermentation products produced by various Streptomyces species.
    Type: Grant
    Filed: February 17, 1976
    Date of Patent: June 21, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Seemon H. Pines, Matthew A. Kozlowski
  • 3-Substituted methyl-7-acylamino-7-methoxy-2-cephem-4-carboxylic acid and its esters
    Patent number: 3987040
    Abstract: Process for preparing an ester of 3-substituted methyl-7-acylamido-7-methoxy(or hydrogen)-2-cephem-4-carboxylic acid and its corresponding sulfoxide by treating an ester of 3-carbamoyloxymethyl(or 3-lower alkanoyloxymethyl)-7-acylamido-7-methoxy(or hydrogen)-2-cephem-4-carboxyli c acid with a hydrohalic acid or another compound containing an active hydrogen and then with an oxidizing agent. The products obtained are useful as intermediates in the preparation of antibiotics.
    Type: Grant
    Filed: December 5, 1974
    Date of Patent: October 19, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Theresa Y. Cheng, Sandor Karady, Seemon H. Pines, Meyer Sletzinger
  • Process for preparing indene acetic acids
    Patent number: 3970693
    Abstract: Process for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid by reacting fluorobenzene with an acid halide, to form an indanone, reaction of the indanone with a methylthio (or methylsulfinyl) benzyl compound to form 5-fluoro-2-methyl-1-(p-methylthiobenzyl) or (p-methylsulfinylbenzyl)-indene and reacting said indene with a glyoxylic acid.This invention relates to new processes for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid, to intermediates thereof and processes for said intermediates.
    Type: Grant
    Filed: July 5, 1974
    Date of Patent: July 20, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Roger J. Tull, Robert F. Czaja, Richard F. Shuman, Seemon H. Pines
  • Preparation of 7-acylamido-7-methoxy-3-substituted methyl-3(or 2)-cephem-4-carboxylic acid and its S-oxides
    Patent number: 3962231
    Abstract: A process for preparing 7-acylamido-7-methoxy-3-substituted methyl-3(or 2)-cephem-4-carboxylic acid and its S-oxide and its salts, esters and amides which comprises treating 7-acylamido-7-methoxy-3-methyl-3(or 2)-cephem-4-carboxylic acid and its S-oxide or the salts or ester derivatives thereof with a reagent capable of replacing a hydrogen atom of the 3-methyl radical with a halo, hydroxy or lower alkanoyloxy radical. The products are either antibiotics or are useful intermediates in the preparation of antibiotics.
    Type: Grant
    Filed: October 21, 1974
    Date of Patent: June 8, 1976
    Assignee: Merck & Co., Inc.
    Inventor: Seemon H. Pines
  • Chemical compounds and processes
    Patent number: 3953520
    Abstract: Haloalkyl derivatives of aromatic compounds are prepared via reaction with dialkoxy or aralkoxy alkanes in the presence of a Lewis acid.
    Type: Grant
    Filed: February 24, 1975
    Date of Patent: April 27, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Robert F. Czaja, Seemon H. Pines, Newton L. Abramson
  • Indenylidene-3-acetic acid process for preparing indene acetic acids
    Patent number: 3944600
    Abstract: Process for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid by reacting fluorobenzene with an acid halide, to form an indanone, reaction of the indanone with a methylthio (or methylsulfinyl)benzyl compound to form 5-fluoro-2-methyl-1-(p-methylthiobenzyl) or (p-methylsulfinylbenzyl)-indene and reacting said indene with a glyoxylic acid. The invention also relates to intermediates thereof and processes for said intermediates.
    Type: Grant
    Filed: September 30, 1974
    Date of Patent: March 16, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Roger J. Tull, Robert F. Czaja, Richard F. Shuman, Seemon H. Pines