Patents by Inventor Seigo Oe

Seigo Oe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11542301
    Abstract: The present application addresses the problem of providing an Fc-binding protein having an improved antibody separation ability. The present application also addresses the problem of providing a high-accuracy antibody separation method using an insoluble carrier having the protein immobilized thereon. The problems can be solved by: an Fc-binding protein in which at least an amino acid substitution at a specific position therein occurs and which has reduced affinity for an antibody; and an antibody separation method including allowing an equilibration buffer solution to pass through a column in which an insoluble carrier having the protein immobilized thereon is filled to equilibrate the column, adding a solution containing an antibody to cause the adsorption of the antibody onto the carrier, and eluting the antibody adsorbed on the carrier using an elution solution.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: January 3, 2023
    Assignee: TOSOH CORPORATION
    Inventors: Yosuke Terao, Yoshiharu Asaoka, Ryoko Otake, Satoshi Endo, Naoki Yamanaka, Yukie Yamamoto, Seigo Oe
  • Patent number: 11427828
    Abstract: The present invention addresses the problem of providing FcRn having improved stability with respect to heat and acids, a method for producing said FcRn, an antibody adsorbent in which said FcRn is used, and an antibody isolation method in which said adsorbent is used. The above problem is solved by substituting an amino acid residue at a specific position in an extracellular region of a human FcRn ? chain and/or a ?2 microglobulin region of a human FcRn ? chain by another specific amino acid.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: August 30, 2022
    Assignee: TOSOH CORPORATION
    Inventors: Yosuke Terao, Naoki Yamanaka, Natsuko Kizu, Satoshi Endo, Seigo Oe
  • Publication number: 20210261605
    Abstract: The present invention relates to an Fc-binding protein exhibiting improved alkaline resistance, a method for producing said protein, an antibody adsorbent obtained by immobilizing said protein on a carrier, and a method for separating an antibody using said adsorbent.
    Type: Application
    Filed: October 26, 2018
    Publication date: August 26, 2021
    Applicant: TOSOH CORPORATION
    Inventors: Ryoko WATANABE, Satoshi ENDO, Yosuke TERAO, Seigo OE
  • Publication number: 20200283779
    Abstract: The present invention addresses the problem of providing FcRn having improved stability with respect to heat and acids, a method for producing said FcRn, an antibody adsorbent in which said FcRn is used, and an antibody isolation method in which said adsorbent is used. The above problem is solved by substituting an amino acid residue at a specific position in an extracellular region of a human FcRn ? chain and/or a ?2 microglobulin region of a human FcRn ? chain by another specific amino acid.
    Type: Application
    Filed: April 13, 2018
    Publication date: September 10, 2020
    Applicant: TOSOH CORPORATION
    Inventors: Yosuke TERAO, Naoki YAMANAKA, Natsuko KIZU, Satoshi ENDO, Seigo OE
  • Publication number: 20200223885
    Abstract: The present application addresses the problem of providing an Fc-binding protein having an improved antibody separation ability. The present application also addresses the problem of providing a high-accuracy antibody separation method using an insoluble carrier having the protein immobilized thereon. The problems can be solved by: an Fc-binding protein in which at least an amino acid substitution at a specific position therein occurs and which has reduced affinity for an antibody; and an antibody separation method including allowing an equilibration buffer solution to pass through a column in which an insoluble carrier having the protein immobilized thereon is filled to equilibrate the column, adding a solution containing an antibody to cause the adsorption of the antibody onto the carrier, and eluting the antibody adsorbed on the carrier using an elution solution.
    Type: Application
    Filed: February 7, 2018
    Publication date: July 16, 2020
    Applicant: TOSOH CORPORATION
    Inventors: Yosuke TERAO, Yoshiharu ASAOKA, Ryoko OTAKE, Satoshi ENDO, Naoki YAMANAKA, Yukie YAMAMOTO, Seigo OE
  • Patent number: 8551752
    Abstract: Disclosed is a T7 RNA polymerase mutant having improved thermal stability and/or specific activity in comparison with wild-type T7-like bacteriophage RNA polymerase, wherein at least one amino acid residue corresponding to at least one of the amino acid residues selected from the group at least consisting of glutamine at position 768, lysine at position 179 and valine at position 685 of the amino acid sequence that composes wild-type T7 RNA polymerase shown in SEQ ID NO: 6, is substituted with another amino acid.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: October 8, 2013
    Assignee: Tosoh Corporation
    Inventors: Seigo Oe, Hiroshi Sato, Teruhiko Ide
  • Publication number: 20110136181
    Abstract: Disclosed is a T7 RNA polymerase mutant having improved thermal stability and/or specific activity in comparison with wild-type T7-like bacteriophage RNA polymerase, wherein at least one amino acid residue corresponding to at least one of the amino acid residues selected from the group at least consisting of glutamine at position 768, lysine at position 179 and valine at position 685 of the amino acid sequence that composes wild-type T7 RNA polymerase shown in SEQ ID NO: 6, is substituted with another amino acid.
    Type: Application
    Filed: August 7, 2009
    Publication date: June 9, 2011
    Applicant: TOSOH CORPORATION
    Inventors: Seigo Oe, Hiroshi Sato, Teruhiko Ide