Patents by Inventor Seiichiro Tabuchi
Seiichiro Tabuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8273745Abstract: The present invention relates to a novel compound or a salt thereof, which is useful as a CRTH2 antagonist, especially as a medicament for disorder that participates eosinophil, for example, allergic disorder such as asthma, allergic rhinitis, allergic dermatitis, conjunctival inflammation, hives, eosinophilic bronchitis, food allergy, inflammation of the nasal sinuses, multiple sclerosis, angiitis, or chronic obstructive pulmonary disease (COPD) and the like.Type: GrantFiled: December 13, 2007Date of Patent: September 25, 2012Assignee: Astellas Pharma IncInventors: Tadashi Terasaka, Tatsuya Zenkoh, Hisashi Hayashida, Hiroshi Matsuda, Junji Sato, Yoshimasa Imamura, Hiroshi Nagata, Norio Seki, Yoshiyuki Tenda, Mamoru Tasaki, Masahiro Takeda, Seiichiro Tabuchi, Minoru Yasuda, Kazunori Tsubaki
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Publication number: 20100009991Abstract: The present invention relates to a novel compound or a salt thereof, which is useful as a CRTH2 antagonist, especially as a medicament for disorder that participates eosinophil, for example, allergic disorder such as asthma, allergic rhinitis, allergic dermatitis, conjunctival inflammation, hives, eosinophilic bronchitis, food allergy, inflammation of the nasal sinuses, multiple sclerosis, angiitis, or chronic obstructive pulmonary disease (COPD) and the like.Type: ApplicationFiled: December 13, 2007Publication date: January 14, 2010Applicant: Astellas Pharma Inc.Inventors: Tadashi Terasaka, Tatsuya Zenkoh, Hisashi Hayashida, Hiroshi Matsuda, Junji Sato, Yoshimasa Imamura, Hiroshi Nagata, Norio Seki, Yoshiyuki Tenda, Mamoru Tasaki, Masahiro Takeda, Seiichiro Tabuchi, Minoru Yasuda, Kazunori Tsubaki
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Patent number: 7265120Abstract: A pyrazine derivative of the following formula (I): wherein R1 is hydrogen or optionally substituted lower alkyl; X is hydrogen, halogen, hydroxy, cyano, acyl, or amino, aryl, heterocyclic group or the like; Y is hydrogen, halogen, hydroxy, acyl, amino, or the like; Z is aryl or heteroaryl, each of which is optionally substituted; or a salt thereof. The pyrazine compound (I) and a salt thereof of the present invention are adenosine antagonists and are useful for the prevention and/or treatment of depression, dementia (e.g. Alzheimer's disease, cerebrovascular dementia, dementia accompanying Parkinson's disease, etc.), Parkinson's disease, anxiety, pain, cerebrovascular disease (e.g. stroke, etc.), heart failure and the like.Type: GrantFiled: March 24, 2005Date of Patent: September 4, 2007Assignee: Astellas Pharma Inc.Inventors: Hideo Tsutsumi, Seiichiro Tabuchi, Masatoshi Minagawa, Atsushi Akahane
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Publication number: 20050222159Abstract: A pyrazine derivative of the following formula (I): wherein R1 is hydrogen or optionally substituted lower alkyl; X is hydrogen, halogen, hydroxy, cyano, acyl, or amino, aryl, heterocyclic group or the like; Y is hydrogen, halogen, hydroxy, acyl, amino, or the like; Z is aryl or heteroaryl, each of which is optionally substituted; or a salt thereof. The pyrazine compound (I) and a salt thereof of the present invention are adenosine antagonists and are useful for the prevention and/or treatment of depression, dementia (e.g. Alzheimer's disease, cerebrovascular dementia, dementia accompanying Parkinson's disease, etc.), Parkinson's disease, anxiety, pain, cerebrovascular disease (e.g. stroke, etc.), heart failure and the like.Type: ApplicationFiled: March 24, 2005Publication date: October 6, 2005Applicant: Fujisawa Pharmaceutical Co. Ltd.Inventors: Hideo Tsutsumi, Seiichiro Tabuchi, Masatoshi Minagawa, Atsushi Akahane
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Publication number: 20050004134Abstract: A thiazole derivative of the formula (I): wherein R is a 1-optionally substituted-6-oxo-1,6-dihydro-3-pyridazinyl, R? is an optionally substituted phenyl, and R2 is hydrogen, a group of the formula (i): wherein R4 is hydrogen, lower alkyl or lower alkenyl, and R5 is hydrogen, optionally substituted lower alkyl, acyl, cyclo(lower)alkyl, lower alkenyl, optionally substituted aryl or heterocyclic, or a group of the formula (ii): wherein X is oxygen or sulfur, R8 is hydrogen or lower alkyl, R9 is hydrogen, optionally substituted lower alkyl, cyclo(lower)alkyl, lower alkoxy or mono- or di-lower alkylamino or R8 and R9 may combine together to form optionally substituted saturated N-containing heterocyclic, or a salt thereof.Type: ApplicationFiled: November 8, 2002Publication date: January 6, 2005Inventors: Hideo Tsutsumi, Seiichiro Tabuchi, Atsushi Akahane, Hironobu Yasuda, Hiroki Omori, Kiyoshi Temmaru, Atsuhiko Zanka
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Publication number: 20040067955Abstract: A pyridazinone or pyridone compound of the following formula (I).Type: ApplicationFiled: September 3, 2003Publication date: April 8, 2004Applicant: Fujisawa Pharmaceutical Co. Ltd.Inventors: Seiichiro Tabuchi, Hideo Tsutumi, Atsushi Akahane, Yoshinari Sato
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Publication number: 20020183313Abstract: Benzodiazepine derivatives of the formula: 1Type: ApplicationFiled: March 20, 2002Publication date: December 5, 2002Applicant: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yoshinari Sato, Seiichiro Tabuchi, Hitoshi Mitsui, Ikuyo Katsumi, Naoko Yamamoto
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Publication number: 20020002163Abstract: Benzodiazepine derivatives of the formula: 1Type: ApplicationFiled: July 5, 2001Publication date: January 3, 2002Applicant: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yoshinari Sato, Seiichiro Tabuchi, Hitoshi Mitsui, Ikuyo Katsumi, Naoko Yamamoto
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Patent number: 6300344Abstract: Heterocyclic compounds of the formula: wherein R1 is carboxy or protected carboxy, R2 is aryl which may have suitable substituent(s), R3 is aryl which may have suitable substituent(s), R4 is hydrogen, lower alkyl, hydroxy or aryl, A1 is lower alkylene, etc., etc. and n is 0 or 1, and pharmaceutically acceptable salts thereof which are useful as a medicament.Type: GrantFiled: July 20, 1999Date of Patent: October 9, 2001Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kiyoshi Taniguchi, Kouji Hattori, Kazunori Tsubaki, Osamu Okitsu, Seiichiro Tabuchi
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Patent number: 6291452Abstract: Benzodiazepine derivatives of the formula: wherein R2 is alkyl or cycloalkyl-alkyl when R4 is hydrogen, or R2 is a variety of specified groups when R4 is alkyl, halogen or dialkylamino, are useful as cholecystokinin antagonists.Type: GrantFiled: April 30, 1999Date of Patent: September 18, 2001Assignees: Fujisawa Pharmacetical Co., Ltd., Nippon Shokubai Co., Ltd.Inventors: Yoshinari Sato, Seiichiro Tabuchi, Hitoshi Mitsui, Ikuyo Katsumi, Naoko Yamamoto
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Patent number: 6025375Abstract: Heterocyclic compounds of the formula: ##STR1## whereinR.sup.1 is carboxy or protected carboxy,R.sup.2 is aryl which may have suitable substituent(s),R.sup.3 is aryl which may have suitable substituent(s),A.sup.1 is lower alkylene,A.sup.2 is bond or lower alkylene and-Q- is ##STR2## etc., and pharmaceutically acceptable salts thereof which are useful as a medicament.Type: GrantFiled: June 5, 1998Date of Patent: February 15, 2000Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kiyoshi Taniguchi, Masanobu Nagano, Kouji Hattori, Kazunori Tsubaki, Osamu Okitsu, Seiichiro Tabuchi
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Patent number: 5972965Abstract: This invention relates to new heterocyclic compounds, compositions, process of making and method of use thereof for inhibition of platelet aggregation, vasodilation, antihypertensive activity and prostaglandin I.sub.2 agonist.Type: GrantFiled: January 21, 1998Date of Patent: October 26, 1999Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kiyoshi Taniguchi, Kouji Hattori, Kazunori Tsubaki, Osamu Okitsu, Seiichiro Tabuchi
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Patent number: 5863918Abstract: A compound or the formula: ##STR1## wherein R.sup.1 is carboxy or protected carboxy, R.sup.2 is hydrogen, hydroxy or protected hydroxy,R.sup.3 is hydrogen, hydroxy, protected hydroxy, etc.,R.sup.4 is hydrogen or halogen,A.sup.1 is lower alkylene,A.sup.2 is bond or lower alkylene,--R.sup.5 is ##STR2## (in which R.sup.6 is mono(or di or tri)aryl(lower)alkyl and Z is N or CH), etc., and ##STR3## etc., and a pharmaceutically acceptable salt thereof which are useful as medicaments.Type: GrantFiled: February 23, 1998Date of Patent: January 26, 1999Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kiyoshi Taniguchi, Masanobu Nagano, Kouji Hattori, Kazunori Tsubaki, Osamu Okitsu, Seiichiro Tabuchi
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Patent number: 5763489Abstract: A compound of the formula ##STR1## wherein R.sup.1 is carboxy or protected carboxy,R.sup.2 is hydrogen, hydroxy or protected hydroxy,R.sup.3 is hydrogen, hydroxy, protected hydroxy, etc.,R.sup.4 is hydrogen or halogen,A.sup.1 is lower alkylene,A.sup.2 is bond or lower alkylene,--R.sup.5 is ##STR2## (in which R.sup.6 is mono(or di or tri)aryl(lower)alkyl and Z is N or CH), etc., and ##STR3## and a pharmaceutically acceptable salt thereof which are useful as medicaments.Type: GrantFiled: October 10, 1996Date of Patent: June 9, 1998Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kiyoshi Taniguchi, Masanobu Nagano, Kouji Hattori, Kazunori Tsubaki, Osamu Okitsu, Seiichiro Tabuchi
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Patent number: 5763437Abstract: Benzodiazepine derivatives of formula (I) wherein R.sup.1 is aryl which may have one or more suitable substituent(s), R.sup.2 is C.sub.3 -C.sub.8 cycloalkyl which may have one or more suitable substituent(s), A is lower alkylene, R.sup.3 is a heterocyclic group selected from the group consisting of tetrahydrofuryl, dioxolanyl, filryl, thienyl, isoxazolyl, pyridyl, benzimidazolyl, benzotiazolyl, benzoxazolyl, benzopyrany, quinolyl, isoquinolyl, tetrahydroisoquinolyl, benzothienyl and benzofuryl, each of which may have one or more suitable substituent(s), or a pharmaceutically acceptable salt thereof, which are useful as a medicament.Type: GrantFiled: January 29, 1997Date of Patent: June 9, 1998Assignees: Fujisawa Pharmaceutical Co., Ltd., Nippon Shokubai Co., Ltd.Inventors: Yoshinari Sato, Kazuo Sakane, Seiichiro Tabuchi, Hitoshi Mitsui, Ikuyo Katsumi, Yuichi Satoh