Abstract: A load port includes a first pin projecting on a dock plate and provided on the dock plate so as to be pushed down, and a first detection unit provided on the base portion and configured to detect that the dock plate is located at a first position. The first detection unit includes a movable member capable of displacing in a moving direction of the dock plate, and a first sensor configured to detect the displacement of the movable member. The movable member is arranged at a position to abut against the first pin that is in a pushed down state in a process in which the dock plate moves from a second position to the first position.

Abstract: A load port includes a first pin projecting on a dock plate and provided on the dock plate so as to be pushed down, and a first detection unit provided on the base portion and configured to detect that the dock plate is located at a first position. The first detection unit includes a movable member capable of displacing in a moving direction of the dock plate, and a first sensor configured to detect the displacement of the movable member. The movable member is arranged at a position to abut against the first pin that is in a pushed down state in a process in which the dock plate moves from a second position to the first position.

Abstract: A load port includes a first pin projecting on a dock plate and provided on the dock plate so as to be pushed down, and a first detection unit provided on the base portion and configured to detect that the dock plate is located at a first position. The first detection unit includes a movable member capable of displacing in a moving direction of the dock plate, and a first sensor configured to detect the displacement of the movable member. The movable member is arranged at a position to abut against the first pin that is in a pushed down state in a process in which the dock plate moves from a second position to the first position.

Abstract: The present invention provides a tau exon 10 skipping-promoting antisense oligonucleotide containing at least one 2?-O, 4?-C-ethylene-bridged nucleic acid, and a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a region consisting of the nucleotide sequence shown in SEQ ID NO: 44 in exon 10 of a tau mRNA precursor. In addition, the present invention provides a tau exon 10 skipping-suppressing antisense oligonucleotide containing at least one 2?-O, 4?-C-ethylene-bridged nucleic acid, and a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a region consisting of the nucleotide sequence shown in SEQ ID NO: 45 in intron 10 of a tau mRNA precursor.

Abstract: The present invention provides a suppression type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in any of SEQ ID NOs: 2-4, and a promotion type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in SEQ ID NO: 5.

Abstract: A load port includes a first pin projecting on a dock plate and provided on the dock plate so as to be pushed down, and a first detection unit provided on the base portion and configured to detect that the dock plate is located at a first position. The first detection unit includes a movable member capable of displacing in a moving direction of the dock plate, and a first sensor configured to detect the displacement of the movable member. The movable member is arranged at a position to abut against the first pin that is in a pushed down state in a process in which the dock plate moves from a second position to the first position.

Abstract: The present invention provides a suppression type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in any of SEQ ID NOs: 2-4, and a promotion type antisense oligonucleotide targeting TDP-43 mRNA, containing a nucleotide sequence complementary to a sequence consisting of at least 10 continuous nucleotides in a nucleotide sequence shown in SEQ ID NO: 5.

Abstract: Insertion of variant exons of CD44 gene of cancer stem cells into its mRNA is inhibited whereupon the cancer stem cells lose their properties so that they are rendered sensitive to anticancer agents and radiation, possibly leading to cancer treatment. A drug for cancer treatment, comprising an antisense oligonucleotide capable of inducing skipping of variant exon(s) of CD44 gene to thereby increase expression of normal CD44 mRNA, a pharmaceutically acceptable salt thereof, a solvate thereof or a prodrug thereof. An oligonucleotide of 20-23 bp having the entirety or a part of any one of the nucleotide sequences as shown in SEQ ID NOS: 1 to 19, a pharmaceutically acceptable salt thereof, a solvate thereof or a prodrug thereof. A drug for inducing skipping of at least one variant exon selected from the group consisting of variant exons 8, 9 and 10 of CD44 gene, comprising the above-described oligonucleotide, a pharmaceutically acceptable salt thereof, a solvate thereof or a prodrug thereof.

Abstract: Insertion of variant exons of CD44 gene of cancer stem cells into its mRNA is inhibited whereupon the cancer stem cells lose their properties so that they are rendered sensitive to anticancer agents and radiation, possibly leading to cancer treatment. A drug for cancer treatment, comprising an antisense oligonucleotide capable of inducing skipping of variant exon(s) of CD44 gene to thereby increase expression of normal CD44 mRNA, a pharmaceutically acceptable salt thereof, a solvate thereof or a prodrug thereof. An oligonucleotide of 20-23 bp having the entirety or a part of any one of the nucleotide sequences as shown in SEQ ID NOS: 1 to 19, a pharmaceutically acceptable salt thereof, a solvate thereof or a prodrug thereof. A drug for inducing skipping of at least one variant exon selected from the group consisting of variant exons 8, 9 and 10 of CD44 gene, comprising the above-described oligonucleotide, a pharmaceutically acceptable salt thereof, a solvate thereof or a prodrug thereof.

Abstract: A variable compression ratio device for an internal combustion engine includes: a connecting rod, having a small end and a large end, wherein a support hole formed at the small end is pivotally supported by a support shaft of a piston that reciprocates in a cylinder, and a support hole formed at the large end is pivotally supported by a support shaft of a crankshaft; an eccentric sleeve that is rotatably installed between the support hole of the small end or the support hole of the large end and the support shaft, and displaces a center axis of the support hole of the small end or a center axis of the support hole of the large end with respect to a center axis the support shaft; and an actuator that drives and rotates the eccentric sleeve.

Abstract: This invention provides a piston in which the moving piston unit can be prevented from rotating with respect the base piston unit, while suppressing the increase of the sliding resistance the piston has with respect to the cylinder. The circumferential wall of the moving piston unit has a pair of skirt parts opposing each other across a piston boss and a pair of side-wall parts coupling the skirt parts and each having an outer circumferential surface concaved toward the central axis X1 of the piston. The side-wall parts have a penetration part each, which penetrates the side-wall part and extends in the directions the moving piston unit reciprocates with respect to the base piston unit. The base piston unit has rotation preventing projections that project perpendicular to the central axis of the piston and are inserted into the penetration parts.

Abstract: A variable compression ratio device for an internal combustion engine includes: a connecting rod, having a small end and a large end, wherein a support hole formed at the small end is pivotally supported by a support shaft of a piston that reciprocates in a cylinder, and a support hole formed at the large end is pivotally supported by a support shaft of a crankshaft; an eccentric sleeve that is rotatably installed between the support hole of the small end or the support hole of the large end and the support shaft, and displaces a center axis of the support hole of the small end or a center axis of the support hole of the large end with respect to a center axis the support shaft; and an actuator that drives and rotates the eccentric sleeve.

Abstract: This invention provides a piston in which the moving piston unit can be prevented from rotating with respect the base piston unit, while suppressing the increase of the sliding resistance the piston has with respect to the cylinder. The circumferential wall of the moving piston unit has a pair of skirt parts opposing each other across a piston boss and a pair of side-wall parts coupling the skirt parts and each having an outer circumferential surface concaved toward the central axis X1 of the piston. The side-wall parts have a penetration part each, which penetrates the side-wall part and extends in the directions the moving piston unit reciprocates with respect to the base piston unit. The base piston unit has rotation preventing projections that project perpendicular to the central axis of the piston and are inserted into the penetration parts.

Abstract: The first output buffer 22 of the driving LSI 20 outputs the first video signal voltage V and the second output buffer outputs the second video signal voltage *V with the opposite polarity from that of the first video signal voltage. The first and the second video signal voltages V, *V are fed to the drain driver 2 of the display panel 1 through a pair of signal wirings. The drain driver 2 supplies the first video signal voltage V to a pixel and the second video signal voltage with the opposite polarity to the pixel adjacent to the fist pixel through the drain line 5 and the TFT9. In this way, any pair of the adjacent pixels in horizontal and vertical direction receives the video signal voltages with opposite polarities from each other.

Abstract: The present invention provides a substrate aligning system which prevents particles or the like from attaching to a substrate such as a wafer used in the semiconductor manufacturing process, and adjusts the orientation of the substrate accurately within a short period of time. According to a substrate aligning system (A) as a preferred embodiment of the present invention, a plurality of rollers (220) push the peripheral portion of a wafer (W) from different directions to align the center of the wafer. While the center of the wafer is kept aligned by the rollers (220), the contacting portion (211) of a contacting member (210) contacts a chip (Wa) of the wafer (W). The contacting member (210) is then moved arcuately to rotate the wafer (W), thus adjusting the orientation of the wafer.

Abstract: The present invention provides a substrate aligning system which prevents particles or the like from attaching to a substrate such as a wafer used in the semiconductor manufacturing process, and adjusts the orientation of the substrate accurately within a short period of time. According to a substrate aligning system (A) as a preferred embodiment of the present invention, a plurality of rollers (220) push the peripheral portion of a wafer (W) from different directions to align the center of the wafer. While the center of the wafer is kept aligned by the rollers (220), the contacting portion (211) of an contacting member (210) contacts a chip (Wa) of the wafer (W). The contacting member (210) is then moved arcuately to rotate the wafer (W), thus adjusting the orientation of the wafer.

Abstract: Data output from a DSP (2) is subjected to pixel number adjustment and temporarily stored in a memory (6). Here, two adjacent pieces of video data are weighted in accordance with a difference between the data input and the display sampling cycle, so as to create new data. Even when video data and a display (9) have a different number of pixels, it is possible to minimize deterioration of the video data image when displayed.

Abstract: The first output buffer 22 of the driving LSI 20 outputs the first video signal voltage V and the second output buffer outputs the second video signal voltage *V with the opposite polarity from that of the first video signal voltage. The first and the second video signal voltages V, *V are fed to the drain driver 2 of the display panel 1 through a pair of signal wirings. The drain driver 2 supplies the first video signal voltage V to a pixel and the second video signal voltage with the opposite polarity to the pixel adjacent to the fist pixel through the drain line 5 and the TFT9. In this way, any pair of the adjacent pixels in horizontal and vertical direction receives the video signal voltages with opposite polarities from each other.

Abstract: Data output from a DSP (2) is subjected to pixel number adjustment and temporarily stored in a memory (6). Here, two adjacent pieces of video data are weighted in accordance with a difference between the data input and the display sampling cycle, so as to create new data. Even when video data and a display (9) have a different number of pixels, it is possible to minimize deterioration of the video data image when displayed.