Abstract: The diagnostic markers that provide novel diagnostic criteria to blastic plasmacytoid dendritic cell neoplasm (BPDCN) has been searched, and the presence of immunoblastoid cytomorphology, 8q24 rearrangement, and MYC expression were established as novel markers for subtyping BPDCN. It has been further found that the inhibitors which directly or indirectly inhibit the expression, functions, or signaling pathways of MYC, such as BET bromodomain-selective inhibitors or aurora kinase inhibitors, are effective in MYC-positive BPDCN, and HDAC inhibitors or BCL2 family protein inhibitors are effective as therapeutic drugs for BPDCN.

Abstract: It is intended to reveal a polynucleotide serving as a novel causative gene of a cancer and, on the basis of this finding, to provide a method for detecting the polynucleotide or a polypeptide encoded thereby, a kit and a primer set for the detection, a method for screening for a substance that inhibits the polypeptide, and a pharmaceutical composition for the treatment of a cancer, containing the inhibiting substance. The detection method of the present invention detects a BRAF fusion protein or a fusion gene encoding the fusion protein, or a PXN or GMDS fusion protein or a fusion gene encoding the fusion protein in a digestive organ-derived sample obtained from a subject.

Abstract: It is intended to reveal a polynucleotide serving as a novel causative gene of a cancer and, on the basis of this finding, to provide a method for detecting the polynucleotide or a polypeptide encoded thereby, a kit and a primer set for the detection, a method for screening for a substance that inhibits the polypeptide, and a pharmaceutical composition for the treatment of a cancer, containing the inhibiting substance. The detection method of the present invention detects a BRAF fusion protein or a fusion gene encoding the fusion protein, or a PXN or GMDS fusion protein or a fusion gene encoding the fusion protein in a digestive organ-derived sample obtained from a subject.

Abstract: A polynucleotide, which is a novel causative gene for cancer, is elucidated, and, based on this finding, provided are a method for detecting the polynucleotide, or a polypeptide encoded by the polynucleotide; a kit and a primer set for the detection; a method for screening an inhibitor of the polypeptide; and a pharmaceutical composition for treating a cancer containing the inhibitor. In the detection method of the present invention, an NTRK3 fusion protein, or a fusion gene encoding the fusion protein, or an ETV6 fusion protein, or a fusion gene encoding the fusion protein, in a sample derived from the digestive system obtained from a subject, is detected.

Abstract: It is intended to reveal a polynucleotide serving as a novel causative gene of a cancer and, on the basis of this finding, to provide a method for detecting the polynucleotide or a polypeptide encoded thereby, a kit and a primer set for the detection, a method for screening for a substance that inhibits the polypeptide, and a pharmaceutical composition for the treatment of a cancer, containing the inhibiting substance. The detection method of the present invention detects a BRAF fusion protein or a fusion gene encoding the fusion protein, or a PXN or GMDS fusion protein or a fusion gene encoding the fusion protein in a digestive organ-derived sample obtained from a subject.

Abstract: The diagnostic markers that provide novel diagnostic criteria to blastic plasmacytoid dendritic cell neoplasm (BPDCN) has been searched, and the presence of immunoblastoid cytomorphology, 8q24 rearrangement, and MYC expression were established as novel markers for subtyping BPDCN. It has been further found that the inhibitors which directly or indirectly inhibit the expression, functions, or signaling pathways of MYC, such as BET bromodomain-selective inhibitors or aurora kinase inhibitors, are effective in MYC-positive BPDCN, and HDAC inhibitors or BCL2 family protein inhibitors are effective as therapeutic drugs for BPDCN.

Abstract: A polynucleotide, which is a novel causative gene for cancer, is elucidated, and, based on this finding, provided are a method for detecting the polynucleotide, or a polypeptide encoded by the polynucleotide; a kit and a primer set for the detection; a method for screening an inhibitor of the polypeptide; and a pharmaceutical composition for treating a cancer containing the inhibitor. In the detection method of the present invention, an NTRK3 fusion protein, or a fusion gene encoding the fusion protein, or an ETV6 fusion protein, or a fusion gene encoding the fusion protein, in a sample derived from the digestive system obtained from a subject, is detected.

Abstract: An image forming apparatus capable of executing a plurality of functions at the same time to promote efficient use thereof. The apparatus includes reading means for reading a document, recording means for forming an image on a sheet, and an operating section for setting modes and displaying information. Control means causes the recording means to print simultaneously and continuously image data read by the reading means and a plurality of independent data written to a memory by a plurality of functions.

Abstract: A magnification changing system for a copier. When any one of a document longitudinal key, a document lateral key, a copy longitudinal key and a copy lateral key is pressed, all the data associated with that key are displayed so that an operator is clearly informed of whether or not the entry of particular data is requested.

Abstract: A digital copier having a density control system. The background of the original document is digitally erased based on the density of the background. The image data is separately controlled and not effected by the background erasing process. A manual operating control is provided in conjunction with an automatic density mode in order to control the image data. The particular level of the image data can be adjusted even in the automatic density mode.

Abstract: A digital copier using a laser card or like external storing medium for storing image data. A remaining amount of memory capacity of a laser card is displayed in terms of the number of papers of a particular size or by percent. Based on the remaining amount of capacity, image data are compressed and reduced, the reduction ratio being also recorded in the card. When the contents of a series of documents cannot be accommodated in a single card, the first card is provided with a mark which shows that the second card is to follow.

Abstract: A digital copier using a laser card or like external storing medium for storing image data. A remaining amount of memory capacity of a laser card is displayed in terms of the number of papers of a particular size or by percent. Based on the remaining amount of capacity, image data are compressed and reduced, the reduction ratio being also recorded in the card. When the contents of a series of documents cannot be accommodated in a single card, the first card is provided with a mark which shows that the second card is to follow.

Abstract: A copier with an optional facsimile function is constructed such that when the facsimile function completes the reception of facsimile data while no manipulation is performed for a predetermined period of time in a copy mode, the facsimile data received are printed out. When the reception of facsimile data by the facsimile function while the copier is in a preheat mode, those facsimile data are also printed out.

Abstract: A copier with an optional facsimile mechanism and a method of controlling such a copier. A person can easily and efficiently switch the operation mode of the copier from a copy mode to a facsimile mode and from the facsimile mode to the copy mode.

Abstract: A multi-copy system for a digital copier includes store means for storing data which are provided by one main scanning. The data stored in the store means are produced a plurality of times within a period of time of one main scanning to provide a multi-copy. Different types of lines such as phantom lines, solid lines and similar borders may be generated between the multiple copies.