Patents by Inventor Seiya Makino
Seiya Makino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230371536Abstract: The present invention provides at least one protein selected from the group consisting of the following proteins (a) to (d): (a) a protein which is composed of an amino acid sequence set forth in SEQ ID NO: 1; (b) a protein which is, in the amino acid sequence set for the in SEQ ID NO: 1, composed of an amino acid sequence in which one or more amino acids other than serine, leucine, phenylalanine, serine, and aspartic acid at positions 334 to 338 are substituted, deleted, inserted, and/or added and has an effect of improving the immunostimulatory activity of exopolysaccharides of lactic acid bacteria; (c) a protein which is composed of an amino acid sequence having 80% or more identity with the amino acid sequence set forth in SEQ ID NO: 1, has serine, leucine, phenylalanine, serine, and aspartic acid from the N-terminal side as amino acids corresponding to positions 334 to 338 of the amino acid sequence set forth in SEQ ID NO: 1, and has an effect of improving the immunostimulatory activity of exopolysaccType: ApplicationFiled: October 8, 2021Publication date: November 23, 2023Applicant: MEIJI CO., LTD.Inventors: Shin FUJIWARA, Seiya MAKINO
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Publication number: 20220288140Abstract: A fermented milk for improving autonomic nervous function containing at least one lactic acid bacterial species of the genus Lactobacillus and its metabolite. The lactic acid bacterial species of the genus Lactobacillus is selected from the group consisting of Lactobacillus delbrueckii, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus gasseri, Lactobacillus rhamnosus and Lactobacillus acidophilus. The lactic acid bacterial strain of the genus Lactobacillus is preferably Lactobacillus delbrueckii subsp. bulgaricus OLL1073R-1(FERM BP-10741).Type: ApplicationFiled: May 31, 2022Publication date: September 15, 2022Applicants: MEIJI CO., LTD., University Public Corporation OsakaInventors: Yasuyoshi WATANABE, Kei MIZUNO, Jun HENMI, Seiya MAKINO, Hiroshi KANO
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Publication number: 20210267226Abstract: It is an objective of the present invention to newly create a method of improving quality of sleep and to increase consumer options for such a method. In the method according to the present invention, at least one (i) at least one lactic acid bacterium of genus Lactobacillus selected from the group consisting of Lactobacillus delbrueckii, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus gasseri, Lactobacillus paragasseri, Lactobacillus rhamnosus and Lactobacillus acidophilus and (ii) its metabolite or a composition containing the same is ingested by an organism to improve quality of sleep of the organism, to improve overall sense of health of the organism, or to improve vitality of the organism. Here, the lactic acid bacterium of the genus Lactobacillus is preferably Lactobacillus delbrueckii subsp. bulgaricus, and more preferably Lactobacillus delbrueckii subsp. bulgaricus OLL1073R-1(FERM BP-10741).Type: ApplicationFiled: February 26, 2021Publication date: September 2, 2021Applicant: MEIJI CO., LTD.Inventors: Seiya MAKINO, Hiroshi KANO
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Publication number: 20200360451Abstract: A fermented milk for improving autonomic nervous function containing at least one lactic acid bacterial species of the genus Lactobacillus and its metabolite. The lactic acid bacterial species of the genus Lactobacillus is selected from the group consisting of Lactobacillus delbrueckii, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus gasseri, Lactobacillus rhamnosus and Lactobacillus acidophilus. The lactic acid bacterial strain of the genus Lactobacillus is preferably Lactobacillus delbrueckii subsp. bulgaricus OLL1073R-1(FERM BP-10741).Type: ApplicationFiled: May 1, 2020Publication date: November 19, 2020Applicants: MEIJI CO., LTD., University Public Corporation OsakaInventors: Yasuyoshi WATANABE, Kei MIZUNO, Jun HENMI, Seiya MAKINO, Hiroshi KANO
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Publication number: 20190150463Abstract: A composition for suppressing deterioration of an acquired immune function according to the present invention includes, as an active ingredient, lactic acid bacteria products from lactic acid bacteria of the genus Lactobacillus. This composition for suppressing deterioration of the acquired immune function suppresses deterioration of the acquired immune function due to the use of an anti-influenza drug. The lactic acid bacteria of the genus Lactobacillus is preferably a bulgaricus bacterium. For example, the lactic acid bacteria of the genus Lactobacillus may be Lactobacillus delbrueckii subsp. bulgaricus. In the production method according to the present invention, a milk raw material is supplied to lactic acid bacteria of the genus Lactobacillus in order to produce the composition for suppressing deterioration of the acquired immune function to suppress deterioration of the acquired immune function due to the use of an anti-influenza drug.Type: ApplicationFiled: August 15, 2017Publication date: May 23, 2019Inventors: Hiroshi KIDO, Etsuhisa TAKAHASHI, Seiya MAKINO, Hiroshi KANO, Jun HENMI
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Patent number: 10195271Abstract: The present invention addresses the problem of providing an antibody titer-increasing agent, such as an adjuvant, capable of sustaining an effect achieved by, for example, vaccination, which is an antibody titer-increasing agent such as an adjuvant that is safe, convenient and economical and can be easily taken irrespective of age, and a method for manufacturing the same. A method for increasing an antibody titer and a method for enhancing the effect of a vaccine, each method comprising using Lactobacillus delbrueckii subspecies bulgaricus OLL1073R-1 or a culture thereof; and an antibody titer-increasing agent such as an adjuvant that comprises Lactobacillus delbrueckii subspecies bulgaricus OLL1073R-1 or a culture thereof.Type: GrantFiled: August 26, 2014Date of Patent: February 5, 2019Assignee: Meiji Co., Ltd.Inventors: Seiya Makino, Jun Henmi, Hiroshi Kano, Yukio Asami, Shuji Ikegami, Hiroyuki Itou, Yoshio Suzuki, Sachio Kawai, Keisuke Sawaki, Ko Okumura, Isao Nagaoka, Kazuyoshi Takeda
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Publication number: 20160206733Abstract: The present invention addresses the problem of providing an antibody titer-increasing agent, such as an adjuvant, capable of sustaining an effect achieved by, for example, vaccination, which is an antibody titer-increasing agent such as an adjuvant that is safe, convenient and economical and can be easily taken irrespective of age, and a method for manufacturing the same. A method for increasing an antibody titer and a method for enhancing the effect of a vaccine, each method comprising using Lactobacillus delbrueckii subspecies bulgaricus OLL1073R-1 or a culture thereof; and an antibody titer-increasing agent such as an adjuvant that comprises Lactobacillus delbrueckii subspecies bulgaricus OLL1073R-1 or a culture thereof.Type: ApplicationFiled: August 26, 2014Publication date: July 21, 2016Applicant: Meiji Co., Ltd.Inventors: Seiya Makino, Jun Henmi, Hiroshi Kano, Yukio Asami, Shuji Ikegami, Hiroyuki Itou, Yoshio Suzuki, Sachio Kawai, Keisuke Sawaki, Yasushi Okumura, Isao Nagaoka, Kazuyoshi Takeda
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Patent number: 9095604Abstract: The purpose of the present invention is to provide a probiotic(s) which can activate an aromatic hydrocarbon receptor (AhR) and can consequently prevent inflammatory damage in the digestive tract. The present invention relates to; a probiotic(s) capable of activating an AhR; an anti-inflammatory agent comprising the probiotic(s); an orally ingestible composition containing the anti-inflammatory agent; and a method for screening for the probiotic(s).Type: GrantFiled: September 8, 2011Date of Patent: August 4, 2015Assignee: Meiji Co, Ltd.Inventors: Shuji Ikegami, Seiya Makino, Takayuki Toshimitsu, Hiroyuki Itoh, Atsuhito Nakao
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Publication number: 20130302844Abstract: The purpose of the present invention is to provide a probiotic(s) which can activate an aromatic hydrocarbon receptor (AhR) and can consequently prevent inflammatory damage in the digestive tract. The present invention relates to; a probiotic(s) capable of activating an AhR; an anti-inflammatory agent comprising the probiotic(s); an orally ingestible composition containing the anti-inflammatory agent; and a method for screening for the probiotic(s).Type: ApplicationFiled: September 8, 2011Publication date: November 14, 2013Applicant: Meiji Co., Ltd.Inventors: Shuji Ikegami, Seiya Makino, Takayuki Toshimitsu, Hiroyuki Itoh, Atsuhito Nakao
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Patent number: 8110607Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: GrantFiled: September 8, 2010Date of Patent: February 7, 2012Assignee: Meiji Co., Ltd.Inventors: Yoshio Sato, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami
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Publication number: 20110009491Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: ApplicationFiled: September 8, 2010Publication date: January 13, 2011Applicant: MEIJI DAIRIES CORPORATIONInventors: Yoshio SATO, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami
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Patent number: 7834061Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: GrantFiled: August 19, 2009Date of Patent: November 16, 2010Assignee: Meiji Dairies CorporationInventors: Yoshio Sato, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami
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Publication number: 20090312425Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: ApplicationFiled: August 19, 2009Publication date: December 17, 2009Applicant: MEIJI DAIRIES CORPORATIONInventors: Yoshio Sato, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami
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Patent number: 7629155Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: GrantFiled: April 9, 2008Date of Patent: December 8, 2009Assignee: Meiji Dairies CorporationInventors: Yoshio Sato, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami
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Publication number: 20080194688Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: ApplicationFiled: April 9, 2008Publication date: August 14, 2008Applicant: MEIJI DAIRIES CORPORATIONInventors: Yoshio SATO, Seiya MAKINO, Nobuo YODA, Kakuhei ISAWA, Tomonori KAMIYAMA, Kenichi HOJO, Mizue SAITO, Naoki TAKETOMO, Keisuke FURUICHI, Shuji IKEGAMI
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Patent number: 7374915Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: GrantFiled: August 6, 2002Date of Patent: May 20, 2008Assignee: Meiji Dairies CorporationInventors: Yoshio Sato, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami
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Publication number: 20040241815Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.Type: ApplicationFiled: July 13, 2004Publication date: December 2, 2004Inventors: Yoshio Sato, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami