Abstract: The present invention relates to a compound of formula (I) capable of inhibiting plasmin activity and having blood coagulation and hemostasis activity, and a pharmaceutically acceptable salt, hydrate, isomer, prodrug and mixture thereof, wherein R1 to R3 are as defined in the description.

Abstract: A one-handed press-open cosmetic container includes a bottle body assembly and a cap assembly, and the cap assembly is fixed to the snap-fit groove of the bottle neck by the clasps of the claws in the cap assembly; wherein the cap assembly includes an outer and inner cap and claws, wherein the clasps are equally spaced and L-shaped, disposed down inwardly, and the ends are provided with inwardly humped heads, the clasps are respectively snapped into the clasp holes at the top corners of the inner cap, and securely snap-fit to the snap-fit groove through the clasp head, the top center of the resilient disc surface of the claws includes an upwardly humped button column, which extends from or is disposed in the center hole of the outer cap, when a force is applied, the claws drive the clasp head to open outwardly until it detaches from the snap ring.

Abstract: A cardiac lead includes a half-domed, or semi-spherical shaped, or asymmetrical oval or circular distal assembly with or without an active fixation mechanism. The half-domed or semi-spherical or asymmetrical oval or circular shape provides directionality as to whether a flat side of the lead is facing the myocardial tissue and therefore the active fixation mechanism can be deployed safely into the myocardial tissue. Pacing/sensing electrodes may be constructed on the flat side of the lead to avoid the stimulation of the phrenic nerve.

Abstract: A cardiac lead includes a half-domed or semi-spherical shaped distal assembly and an active fixation mechanism. The half-domed or semi-spherical shape provides directionality as to whether a flat side of the lead is facing the myocardial tissue and therefore the active fixation mechanism can be deployed safely into the myocardial tissue.

Abstract: This invention relates to a device for continuously visualizing the esophagus during atrial finrillation ablation procedure to reduce the risk of developing atrio-esophagial fistula as the result of atrial fibrillation ablation.