Abstract: Systems and methods for objective assessment of patient response for calibration of therapeutic interventions are pro-vided. Analysis of a human patient's speech provides an objective measurement for pain or discomfort experienced by a patient. This speech analysis can then be used to provide personalized therapeutic interventions which more effectively address the needs of the patient. The speech analysis provides not only a personalized initial intervention, but in the case of ongoing interventions the speech analysis can further refine the intervention as a patient's response changes over time.