Abstract: Human antibodies and antigen-binding portions of those antibodies that specifically bind extended Type I chain glycosphingolipids are provided.

Abstract: Human antibodies and antigen-binding portions of those antibodies that specifically bind extended Type I chain glycosphingolipids are provided.

Abstract: Oligosaccharides specific for Chlamydia mediate attachment of the organism to host cells.

Abstract: A vaccine and method to prevent or to retard the growth and replication of cancer cells that express a carbohydrate wherein the vaccine comprises: (a) a pharmaceutically effective amount of a carbohydrate antigen found on said cancer cells, or a mimetic thereof; and (b) a pharmaceutically acceptable carrier. The carbohydrate antigen can be Tn or sialyl-Tn.

Abstract: A vaccine and method to prevent or to retard the growth and replication of cancer cells that express a carbohydrate wherein the vaccine comprises: (a) a pharmaceutically effective amount of a carbohydrate antigen found on said cancer cells, or a mimetic thereof; and (b) a pharmaceutically acceptable carrier. The carbohydrate antigen can be Tn or sialyl-Tn.

Abstract: Oligosaccharides specific for Chlamydia mediate attachment of the organism to host cells.

Abstract: Oligosaccharides specific for Chlamydia mediate attachment of the organism to host cells.

Abstract: Systematic chemical analysis of glycosphingolipid (GSL) fractions from large quantities of normal human neutrophils and HL60 cells failed to detect GSL's which are binding targets of selectin. A series of long-chain, unbranched polylactosamine GSL's with a terminally sialylated, internally polyfucosylated structure bind selectins.

Abstract: Oligosaccharides specific for Chlamydia mediate attachment of the organism to host cells.

Abstract: Oligosaccharides specific for Chlamydia mediate attachment of the organism to host cells.

Abstract: Systematic chemical analysis of glycosphingolipid (GSL) fractions from large quantities of normal human neutrophils and HL60 cells failed to detect GSL's containing an SLex structure. Instead, the binding target of E-selectin was revealed to be a series of long-chain, unbranched polylactosamine GSL's with a terminally sialylated, internally polyfucosylated structure, called, “myeloglycan”.

Abstract: A vaccine and method to prevent or to retard the growth and replication of cancer cells that express a carbohydrate wherein the vaccine comprises: (a) a pharmaceutically effective amount of a carbohydrate antigen found on said cancer cells, or a mimetic thereof; and (b) a pharmaceutically acceptable carrier. The carbohydrate antigen can be Tn or sialyl-Tn.

Abstract: Oligosaccharides specific for Chlamydia mediate attachment of the organism to host cells.

Abstract: A series of long chain, unbranched polylactosamine glycosphingolipids with terminally sialylated, internally polyfucosylated structures binds selectins.

Abstract: Mannose-containing, branched oligosaccharides mediate binding of chlamydia to mammalian cells. The “high mannose-type” glycan was found to block adhesion of chlamydiae to mammalian cells and thus to inhibit infectivity. The glycan and its mimetics, including multivalent derivatives, can be used as agents for treatment or prevention of chlamydia-based human diseases.

Abstract: Compositions and methods for diagnosing, treating and preventing recurrent E.

Abstract: Oligosaccharides specific for Chlamydia mediate attachment of the organism to host cells.

Abstract: A variety of compounds are provided which are useful as immunogens and as tumor markers. The present invention discloses methods relating to the detection of cancer. Extended forms of the lacto-series type 1 chain are shown to be present in various cancer tissues. The present invention also provides a cell line and the monoclonal antibody produced therefrom. Such an antibody has a number of uses, including in diagnostic or therapeutic methods.

Abstract: An unbranched polylactosamine comprising at least 6 monosaccharides and having terminal .alpha.2.fwdarw.3 sialylation and internal .alpha.1.fwdarw.3 fucosylation at various N-acetylglucosamine residues except for solely at the penultimate N-acetylglucosamine residue.

Abstract: A method for determining susceptibility to E. coli urinary tract infection comprising assaying a sample of epithelial cells for the presence or absence of at least one of Le.sup.a, sialosyl galactosyl-globoside, disialosyl galactosyl-globoside and an extended globo structure carrying the same terminal epitopes as Le.sup.a, sialosyl galactosyl-globoside or disialosyl galactosyl-globoside or assaying a sample of vaginal secretions for the presence or absence of at least one of sialosyl galactosyl-globoside or disialosyl galactosyl-globoside, and detecting the presence or absence of the at least one of Le.sup.