Abstract: The present disclosure, in some aspects, is directed to methods of deisgning an oral drug dosage form formulated and configured to provide an efficacy-based target pharmocokinetic (PK) profile by optmizing the drug concentration-permeability interplay at any time and/or location in the gastrointestinal tract. In other aspects, the present disclosure is directed to oral drug dosage forms having the desired PK profile, and methods of making, such as three-dimentional printing, such oral drug dosage forms to release the drug (and any functional excipients) with the right amount, at the right time, and at the right location.

Abstract: A fitness equipment and an automatic oxygen-generating fitness equipment are disclosed. The fitness equipment comprises a power unit, a sensor unit and an oxygen-generating assembly. The power unit comprises a belt drive turnplate, a belt and a magnetic wheel. Rotation of the belt drive turnplate drives the belt to operate so that the magnetic wheel is driven to rotate. The sensor unit is adapted to detect the belt drive turnplate and generate an activation signal when the belt drive turnplate is rotating. The oxygen-generating assembly comprises a control unit, a motor and an oxygen generator. The control unit is configured to receive the activation signal from the sensor so that the motor is activated to drive the oxygen generator to operate. The control unit may also control the equipment to switch between an oxygen-generating mode and a non-oxygen-generating mode.

Abstract: A fitness equipment and an automatic oxygen-generating fitness equipment are disclosed. The fitness equipment comprises a power unit, a sensor unit and an oxygen-generating assembly. The power unit comprises a belt drive turnplate, a belt and a magnetic wheel. Rotation of the belt drive turnplate drives the belt to operate so that the magnetic wheel is driven to rotate. The sensor unit is adapted to detect the belt drive turnplate and generate an activation signal when the belt drive turnplate is rotating. The oxygen-generating assembly comprises a control unit, a motor and an oxygen generator. The control unit is configured to receive the activation signal from the sensor so that the motor is activated to drive the oxygen generator to operate. The control unit may also control the equipment to switch between an oxygen-generating mode and a non-oxygen-generating mode.