Abstract: The present invention provides methods to improve a cancer patient's response to immune checkpoint inhibitor (ICI) therapy, and functional test to predict likelihood of response. Specifically, the invention provides methods to improve patient's response to immune checkpoint inhibitors using modulators and to predict response to the combination of immune checkpoint inhibitors and modulators.

Abstract: This invention relates to methods of increasing the sensitivity of tumors to anti cancer therapies including antibody therapy, chemotherapy, radiotherapy, and therapies targeting cell signaling pathways such as the MAPK and PI3K pathways and receptor tyrosine kinases (e.g. EGFR). By increasing sensitivity of tumors to these agents, this invention will: (a)Prolong response in already responsive subjects; (b) Increase response rates by converting non-responsive patients into responsive patients; (c) Reverse treatment-induced resistance of tumors to anticancer therapy; and (d) Decrease treatment-associated toxicities by decreasing therapy dosages required for response. The invention also describes predictive tests, to identify patients most likely to respond to the combination treatments.

Abstract: A flexible pipe body and method of producing a flexible pipe body are disclosed. The flexible pipe body includes a collapse resistant layer comprising a radially inner surface and a radially outer surface, the radially inner surface comprising, in cross section, a substantially flat portion and at least one cavity extending from the flat portion radially outwards, and the radially inner surface further comprising, in cross section, at least one aerodynamic feature extending from the flat portion for breaking up a boundary layer of fluid flowing along the flexible pipe body in use.

Abstract: A flexible pipe body and method of producing a flexible pipe body, the flexible pipe body including a collapse resistant layer comprising a radially inner surface and a radially outer surface, the radially inner surface comprising a plurality of substantially regular protrusions and/or depressions extending in a direction perpendicular to a tangent of the radially inner surface, for breaking up a boundary layer of fluid flowing along the flexible pipe body in use.

Abstract: A flexible pipe body and method of producing a flexible pipe body, the flexible pipe body including a collapse resistant layer comprising a radially inner surface and a radially outer surface, the radially inner surface comprising a plurality of substantially regular protrusions and/or depressions extending in a direction perpendicular to a tangent of the radially inner surface, for breaking up a boundary layer of fluid flowing along the flexible pipe body in use

Abstract: A flexible pipe body and method of producing a flexible pipe body are disclosed. The flexible pipe body includes a collapse resistant layer comprising a radially inner surface and a radially outer surface, the radially inner surface comprising, in cross section, a substantially flat portion and at least one cavity extending from the flat portion radially outwards, and the radially inner surface further comprising, in cross section, at least one aerodynamic feature extending from the flat portion for breaking up a boundary layer of fluid flowing along the flexible pipe body in use.

Abstract: According to one aspect of the disclosure, an apparatus for injecting fuel is provided, where the apparatus includes a cone structure that includes a passage to form a swirl of an air-fuel mixture in a combustion chamber. The apparatus also includes at least one adjustable vane positioned in the passage configured to control the swirl of the air-fuel mixture and control a flame stability.

Abstract: A method includes receiving fuel and air into a cup of a turbine fuel nozzle. The method also includes mixing the fuel and air at least partially within the cup. In addition, the method includes directing a fuel air mixture toward a turbine combustor. The method also includes shielding an inner wall of the cup with a blanket of a protective fluid flow to reduce the possibility of flame holding along the inner wall. The protective fluid flow excludes a combustible mixture of fuel and air.