Patents by Inventor Senthil BALA

Senthil BALA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11268902
    Abstract: The invention provides differential refractive index detectors and methods for the use of differential refractive index detectors. In an exemplary embodiment, a differential refractive index detector includes a flow cell body having a proximal end, a distal end, and a flow axis extending between the proximal and the distal end. The flow cell body includes a first chamber and a second chamber and the fluid conduits coupled to the flow cell body can be tapered to reduce dispersion.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: March 8, 2022
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Anthony C. Jeannotte, Mark Basile, Senthil Bala, Colin Fredette
  • Patent number: 10617991
    Abstract: The present technology relates to methodologies, systems and apparatus for separating a liquid and a gas from a multi-phase flow stream. In particular, a gas-liquid separator having a curvilinear flow path sized is described. The flow path is designed to create a shift in the axial velocity of the primary flow field through the gas-liquid separator and generate a secondary flow field effect perpendicular to the primary flow field. The curvilinear flow path can minimize additional dispersion and provide improved efficiencies in fraction collection.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: April 14, 2020
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Senthil Bala, Colin Fredette, Christopher Seith
  • Patent number: 10585077
    Abstract: The present disclosure relates to methodologies, systems and apparatus for cooling a supersaturated or mixed-phase solution to increase the solubility of gases dissolved therein. In a fluid chromatography system, the mobile phase may include a pressurized mixture including a gas, such as CO2, and prior to fraction collection and/or detection a portion of the gas is extracted via a gas/liquid separator. Cooling the substantially liquid phase eluent exiting the gas/liquid separator increases the solubility of any remnant gas still dissolved within the eluent. The increased solubility of the remnant gas prevents out gassing, provides more consistent flow of the eluent through the system, and results in more efficient collection and analysis of a desired sample.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: March 10, 2020
    Assignee: Waters Technologies Corporation
    Inventors: Michael R. Jackson, Christopher Seith, Senthil Bala, Colin Fredette
  • Patent number: 10159913
    Abstract: Methods, systems and apparatus are provided for degassing a supersaturated solution. An example degasser is described having a continuous body of gas-permeable tubing to remove an amount of a gas from the supersaturated solution below the gas's saturation point in the supersaturated solution. The degasser can be connected to at least one of a fraction collector or a detector. The example degasser is sized and/or positioned to cause a change in pressure (?P) across the degasser to drive removal of a dissolved gas from a supersaturated solution passing through the degasser. As a result of the reduction of gas, efficiencies in system flow and fraction collection are achieved.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: December 25, 2018
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Michael R. Jackson, Christopher Seith, Senthil Bala, Colin Fredette, Maruth Sok, Carlos Gomez, Joshua A. Shreve
  • Publication number: 20180231461
    Abstract: The invention provides differential refractive index detectors and methods for the use of differential refractive index detectors. In an exemplary embodiment, a differential refractive index detector includes a flow cell body having a proximal end, a distal end, and a flow axis extending between the proximal and the distal end. The flow cell body includes a first chamber and a second chamber and the fluid conduits coupled to the flow cell body can be tapered to reduce dispersion.
    Type: Application
    Filed: April 13, 2018
    Publication date: August 16, 2018
    Inventors: Anthony C. Jeannotte, Mark Basile, Senthil Bala, Colin Fredette
  • Patent number: 9989459
    Abstract: The invention provides differential refractive index detectors and methods for the use of differential refractive index detectors. In an exemplary embodiment, a differential refractive index detector includes a flow cell body having a proximal end, a distal end, and a flow axis extending between the proximal and the distal end. The flow cell body includes a first chamber and a second chamber and the fluid conduits coupled to the flow cell body can be tapered to reduce dispersion.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: June 5, 2018
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Anthony C. Jeannotte, Mark Basile, Senthil Bala, Colin Fredette
  • Publication number: 20180106770
    Abstract: The present disclosure relates to methodologies, systems and apparatus for cooling a supersaturated or mixed-phase solution to increase the solubility of gases dissolved therein. In a fluid chromatography system, the mobile phase may include a pressurized mixture including a gas, such as CO2, and prior to fraction collection and/or detection a portion of the gas is extracted via a gas/liquid separator. Cooling the substantially liquid phase eluent exiting the gas/liquid separator increases the solubility of any remnant gas still dissolved within the eluent. The increased solubility of the remnant gas prevents out gassing, provides more consistent flow of the eluent through the system, and results in more efficient collection and analysis of a desired sample.
    Type: Application
    Filed: April 7, 2016
    Publication date: April 19, 2018
    Applicant: Waters Technologies Corporation
    Inventors: Michael R. Jackson, Christopher Seith, Senthil Bala, Colin Fredette
  • Publication number: 20170136389
    Abstract: Methods, systems and apparatus are provided for degassing a supersaturated solution. An example degasser is described having a continuous body of gas-permeable tubing to remove an amount of a gas from the supersaturated solution below the gas's saturation point in the supersaturated solution. The degasser can be connected to at least one of a fraction collector or a detector. The example degasser is sized and/or positioned to cause a change in pressure (?P) across the degasser to drive removal of a dissolved gas from a supersaturated solution passing through the degasser. As a result of the reduction of gas, efficiencies in system flow and fraction collection are achieved.
    Type: Application
    Filed: October 25, 2016
    Publication date: May 18, 2017
    Inventors: Michael R. Jackson, Christopher Seith, Senthil Bala, Colin Fredette, Maruth Sok, Carlos Gomez, Joshua A. Shreve
  • Publication number: 20170113171
    Abstract: The present technology relates to methodologies, systems and apparatus for separating a liquid and a gas from a multi-phase flow stream. In particular, a gas-liquid separator having a curvilinear flow path sized is described. The flow path is designed to create a shift in the axial velocity of the primary flow field through the gas-liquid separator and generate a secondary flow field effect perpendicular to the primary flow field. The curvilinear flow path can minimize additional dispersion and provide improved efficiencies in fraction collection.
    Type: Application
    Filed: October 25, 2016
    Publication date: April 27, 2017
    Inventors: Senthil Bala, Colin Fredette, Christopher Seith
  • Publication number: 20160018326
    Abstract: The invention provides differential refractive index detectors and methods for the use of differential refractive index detectors. In an exemplary embodiment, a differential refractive index detector includes a flow cell body having a proximal end, a distal end, and a flow axis extending between the proximal and the distal end. The flow cell body includes a first chamber and a second chamber and the fluid conduits coupled to the flow cell body can be tapered to reduce dispersion.
    Type: Application
    Filed: March 11, 2014
    Publication date: January 21, 2016
    Inventors: Anthony C. JEANOTTE, Mark BASILE, Senthil BALA, Colin FREDETTE