Patents by Inventor Senthil Kumar MUTHUSWAMY

Senthil Kumar MUTHUSWAMY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF CULTURING T CELLS WITH A 4-1BBL FUSION POLYPEPTIDE AND USES OF SAME
    Publication number: 20230048719
    Abstract: Methods of culturing T cells with a 4-1BBL fusion polypeptide are provided. Accordingly there is provided a method of culturing T cells comprising adding to immune cells comprising T cells obtained from a subject having a pathology a PD1-4-1BBL or a SIRPalpha-4-1BBL fusion polypeptide; and culturing the immune cells with the fusion polypeptide for more than 7 days. Also provided are T cells obtainable by the method and uses thereof.
    Type: Application
    Filed: December 30, 2020
    Publication date: February 16, 2023
    Applicants: KAHR Medical Ltd., Beth Israel Deaconess Medical Center, Inc.
    Inventors: Senthil Kumar MUTHUSWAMY, Manuel HIDALGO MEDINA, Qingda MENG, Yaron PEREG, Ayelet CHAJUT
  • METHODS OF CULTURING T CELLS AND USES OF SAME
    Publication number: 20230048361
    Abstract: Methods of culturing T cells are provided. Accordingly there is provided a method of culturing T cells comprising adding to immune cells comprising T cells obtained from a subject having a pathology a non-cellular agent capable of binding 4-1BB and activating said 4-1BB signaling pathway; and culturing the immune cells with said agent for more than 7 days. Also provided are T cells obtainable by the method and uses thereof.
    Type: Application
    Filed: December 30, 2020
    Publication date: February 16, 2023
    Applicants: KAHR Medical Ltd., Beth Israel Deaconess Medical Center, Inc.
    Inventors: Senthil Kumar MUTHUSWAMY, Manuel HIDALGO MEDINA, Qingda MENG, Yaron PEREG, Ayelet CHAJUT