Patents by Inventor Seok Joon Kwon

Seok Joon Kwon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240402161
    Abstract: Methods and systems are directed to multiplex detection of a bacterial pathogen in a sample. A first biotinylated lysin-derived cell wall binding domain is complexed with an avidin layer on a surface. A first bacterial pathogen detection complex including a second biotinylated lysin-derived cell wall binding domain, a detection domain, and an avidin linker complexed between the cell wall binding domain and the detection domain is also provided. The cell wall binding domains are derived from an endolysin, autolysin, bacteriocin, or exolysin, and are configured to bind a cell wall of a target bacterial pathogen. The detection domain includes one or more enzymes, fluorescent material, or DNA for emitting a signal for detection. Target bacterial pathogens present in a sample can thus be detected in a sandwich assay exhibiting increased selectivity and reduced limit of detection relative to traditional ELISA.
    Type: Application
    Filed: August 21, 2024
    Publication date: December 5, 2024
    Applicant: RENSSELAER POLYTCHNIC INSTITUTE
    Inventors: Seok-Joon KWON, Jonathan Seth Dordick, Domyoung KIM, Jungbae KIM, Inseon LEE
  • Patent number: 12157370
    Abstract: An embodiment hybrid powertrain for a vehicle includes a first input shaft configured to be interlocked with an engine, a second input shaft configured to be interlocked with a first motor and to be parallel to the first input shaft, a third input shaft configured to be interlocked with a second motor and to be parallel to the second input shaft, an output shaft mounted parallel to the third input shaft, a first selective mesh device configured to transmit power from the second input shaft to the output shaft at multiple different gear ratios, a second selective mesh device configured to transmit the power from the third input shaft to the output shaft at the multiple different gear ratios, and a third selective mesh device configured to transmit the power from the first input shaft to the second input shaft or the third input shaft.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: December 3, 2024
    Assignees: Hyundai Motor Company, Kia Corporation
    Inventors: Hyuk Joon Kwon, Ho Rim Yang, Buhm Joo Suh, Woul Sun Choi, Seung Wook Lee, Seok Joon Kim, Tal Chol Kim, Yeong Il Choi
  • Patent number: 12122387
    Abstract: When a towing vehicle is driven while towing a towed vehicle having driving force, a controller of the towed vehicle determines wheel slip of the towing vehicle based on driving information of the towing vehicle and determines wheel slip of the towed vehicle based on driving information of the towed vehicle, and upon determining that wheel slip of the towing vehicle or the towed vehicle has occurred or upon determining that wheel slip of each of the towing vehicle and the towed vehicle has occurred, control to increase or decrease driving force of the towed vehicle or control to change the driving force distribution ratio between left and right wheels of the towed vehicle is performed, whereby it is possible to improve driving stability and rough road escape performance of the towing vehicle and the towed vehicle.
    Type: Grant
    Filed: July 27, 2023
    Date of Patent: October 22, 2024
    Assignees: Hyundai Motor Company, Kia Corporation
    Inventors: Woul Sun Choi, Buhm Joo Suh, Yeong Il Choi, Seung Wook Lee, Seok Joon Kim, Tal Chol Kim, Hyuk Joon Kwon
  • Patent number: 12099057
    Abstract: Methods and systems are directed to multiplex detection of a bacterial pathogen in a sample. A first biotinylated lysin-derived cell wall binding domain is complexed with an avidin layer on a surface. A first bacterial pathogen detection complex including a second biotinylated lysin-derived cell wall binding domain, a detection domain, and an avidin linker complexed between the cell wall binding domain and the detection domain is also provided. The cell wall binding domains are derived from an endolysin, autolysin, bacteriocin, or exolysin, and are configured to bind a cell wall of a target bacterial pathogen. The detection domain includes one or more enzymes, fluorescent material, or DNA for emitting a signal for detection. Target bacterial pathogens present in a sample can thus be detected in a sandwich assay exhibiting increased selectivity and reduced limit of detection relative to traditional ELISA.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: September 24, 2024
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Seok-Joon Kwon, Jonathan Seth Dordick, Domyoung Kim, Jungbae Kim, Inseon Lee
  • Publication number: 20240278785
    Abstract: When a towing vehicle is driven while towing a towed vehicle having driving force, a controller of the towed vehicle determines wheel slip of the towing vehicle based on driving information of the towing vehicle and determines wheel slip of the towed vehicle based on driving information of the towed vehicle, and upon determining that wheel slip of the towing vehicle or the towed vehicle has occurred or upon determining that wheel slip of each of the towing vehicle and the towed vehicle has occurred, control to increase or decrease driving force of the towed vehicle or control to change the driving force distribution ratio between left and right wheels of the towed vehicle is performed, whereby it is possible to improve driving stability and rough road escape performance of the towing vehicle and the towed vehicle.
    Type: Application
    Filed: July 27, 2023
    Publication date: August 22, 2024
    Applicants: Hyundai Motor Company, Kia Corporation
    Inventors: Woul Sun CHOI, Buhm Joo Suh, Yeong II Choi, Seung Wook Lee, Seok Joon Kim, Tal Chol Kim, Hyuk Joon Kwon
  • Publication number: 20240201169
    Abstract: A chip system is provided that includes a micropillar chip and a corresponding microwell chip. The micropillars are coated with an anchoring layer, e.g., polydopamine/polylysine/fibronectin, which anchors an amount of a hydrogel composition to the micropillars, the composition including a matrix and a concentration of cancer cells, such as those from a particular patient. Upon gelation, the composition forms a three-dimensional structure with a high cancer cell density mimicking a tumor microenvironment, e.g., allows culturing of the cancer cells in hypoxic conditions representative of the conditions at the patient's tumor. The 3D structures of composition on the micropillars are then stamped into corresponding microwells including media composed of a variety of treatments for testing against the cancer cells.
    Type: Application
    Filed: February 8, 2022
    Publication date: June 20, 2024
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Seok-Joon KWON, Jonathan Seth DORDICK, Sneha GOPAL, Bosung KU
  • Publication number: 20230212643
    Abstract: The oligonucleotide nanostructures enable pattern-recognized targeting of diseases, particularly useful as high-specificity detectors and inhibitors of viruses and toxins, such as for Dengue virus particles. The nanostructures include an oligonucleotide scaffold with a plurality of binders arranged in a pattern conforming to a plurality of surface epitopes of a target disease. Binding of the scaffolds to these surface epitopes has been shown to have inhibitory effects against the target disease. The scaffolds can also include functional domains that activate upon target binding. Assembly of the scaffolds can be achieved via annealing of separate oligonucleotide segments of predetermined length and sequence, which also advantageously define locations of binding domains in the resulting structure. This approach provides precise control over the spacing and orientation of epitope binding sites in the scaffold.
    Type: Application
    Filed: May 18, 2020
    Publication date: July 6, 2023
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Xing WANG, Seok-Joon KWON, Jonathan Seth DORDICK, Robert John LINHARDT, Paul S. KWON
  • Publication number: 20230201249
    Abstract: The composition inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via competitive binding to SARS-CoV-2 spike protein. The composition includes a plurality of sulfated glycosaminoglycans which bind to SARS-CoV-2 spike protein, preventing binding to and uptake by host cells. The sulfated glycosaminoglycans, including N-, 2-O, 3-O, or 6-O sulfate groups, or combinations thereof, include heparins and fucoidans, such as those isolated from brown seaweed. The compositions show antiviral activity, with EC50 as low as 0.08 ?M, and low cytotoxicity, making it promising for clinical use. While established SARS-CoV-2 treatments such as remdesivir need to be administered intravenously, the compositions discussed herein are advantageously capable to being delivered as a nasal spray, metered dose inhaler, oral delivery, etc.
    Type: Application
    Filed: April 2, 2021
    Publication date: June 29, 2023
    Inventors: Robert John LINHARDT, So-Young KIM, Weihua JIN, Jonathan Seth DORDICK, Fuming ZHANG, Seok-Joon KWON, Paul S. KWON, Keith FRASER
  • Publication number: 20220091118
    Abstract: The invention encompasses methods and test strips for detecting the presence of cerebrospinal fluid (CSF) in a biological sample comprising removing sialo-transferrin and selectively detecting or measuring asialo-transferrin in the biological sample.
    Type: Application
    Filed: January 31, 2020
    Publication date: March 24, 2022
    Inventors: Min-Gon Kim, Robert John Linhardt, William J. Sonstein, Jonathan S. Dordick, Seok-Joon Kwon, Jusung Oh
  • Patent number: 11067581
    Abstract: The invention encompasses methods and test strips for detecting the presence of cerebrospinal fluid (CSF) in a biological sample comprising removing sialo-transferrin and selectively detecting or measuring asialo-transferrin in the biological sample.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: July 20, 2021
    Assignees: NSPC TECHNOLOGIES, LLC, RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Seok-Joon Kwon, Robert J. Linhardt, Jonathan S. Dordick, William J. Sonstein, Fuming Zhang
  • Publication number: 20210148904
    Abstract: Methods and systems are directed to multiplex detection of a bacterial pathogen in a sample. A first biotinylated lysin-derived cell wall binding domain is complexed with an avidin layer on a surface. A first bacterial pathogen detection complex including a second biotinylated lysin-derived cell wall binding domain, a detection domain, and an avidin linker complexed between the cell wall binding domain and the detection domain is also provided. The cell wall binding domains are derived from an endolysin, autolysin, bacteriocin, or exolysin, and are configured to bind a cell wall of a target bacterial pathogen. The detection domain includes one or more enzymes, fluorescent material, or DNA for emitting a signal for detection. Target bacterial pathogens present in a sample can thus be detected in a sandwich assay exhibiting increased selectivity and reduced limit of detection relative to traditional ELISA.
    Type: Application
    Filed: May 8, 2018
    Publication date: May 20, 2021
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Seok-Joon Kwon, Jonathan Seth Dordick, Domyoung Kim, Jungbae Kim, Inseon Lee
  • Patent number: 10881673
    Abstract: Provided are a conjugate including a core and sialic acids or derivatives thereof bound to the surface of the core, and use thereof. The conjugate provided in the present invention binds with hemagglutinin on the surface of influenza virus to inhibit the course of infection of influenza virus, thereby preventing or treating infection of influenza virus and also preventing or treating infection of influenza virus resistant to antiviral agents. Accordingly, the conjugate may be widely used in the development of prophylactic or therapeutic agents for influenza virus infection.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: January 5, 2021
    Assignees: Kabio R&D SOO Co., Ltd., Rensselaer Polytechnic Institute
    Inventors: Jong Hwan Kwak, Seok-Joon Kwon, Robert J. Linhardt, Jonathan S. Dordick, Fuming Zhang
  • Publication number: 20190187368
    Abstract: In a method for fabricating a broadband near infrared plasmonic waveguide, the method includes forming a first pattern on a substrate. A metal thin film is evaporated on the substrate on which the first pattern is formed. The first pattern is removed from the substrate on which the metal thin film is evaporated, to remain a second pattern on the substrate on which the metal thin film is evaporated. The substrate on which the second pattern is formed is heated, to induce dewetting, so that metal nano particles are formed on the substrate.
    Type: Application
    Filed: December 11, 2018
    Publication date: June 20, 2019
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Seok Joon KWON, Hyoung Uk KIM, IL KI HAN, KWAN IL LEE, Seonju YEO
  • Patent number: 10251556
    Abstract: Provided is an in vivo bioimaging method including irradiating near-infrared (NIR) light onto a living body, converting the NIR light passed through the living body, into visible light using upconversion nanoparticles (UCNPs), and generating a bioimage of the living body by receiving the visible light using a complementary metal-oxide-semiconductor (CMOS) image sensor.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: April 9, 2019
    Assignees: Korea Institute of Science an Technology, Center of Human-Centered Interaction for Coexistence
    Inventors: Hwa Sup Lim, Seok Joon Kwon, Sang Chul Ahn, Bum Jae You
  • Publication number: 20190004057
    Abstract: The invention encompasses methods and test strips for detecting the presence of cerebrospinal fluid (CSF) in a biological sample comprising removing sialo-transferrin and selectively detecting or measuring asialo-transferrin in the biological sample.
    Type: Application
    Filed: June 17, 2016
    Publication date: January 3, 2019
    Applicants: NEUROLOGICAL SURGERY, P.C., RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Seok-Joon Kwon, Robert J. Linhardt, Jonathan S Dordick, William J. Sonstein, Fuming Zhang
  • Publication number: 20180055367
    Abstract: Provided is an in vivo bioimaging method including irradiating near-infrared (NIR) light onto a living body, converting the NIR light passed through the living body, into visible light using upconversion nanoparticles (UCNPs), and generating a bioimage of the living body by receiving the visible light using a complementary metal-oxide-semiconductor (CMOS) image sensor.
    Type: Application
    Filed: July 31, 2017
    Publication date: March 1, 2018
    Applicants: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, CENTER OF HUMAN-CENTERED INTERACTION FOR COEXISTENCE
    Inventors: Hwa Sup LIM, Seok Joon KWON, Sang Chul AHN, Bum Jae YOU
  • Publication number: 20180050056
    Abstract: Provided are a conjugate including a core and sialic acids or derivatives thereof bound to the surface of the core, and use thereof. The conjugate provided in the present invention binds with hemagglutinin on the surface of influenza virus to inhibit the course of infection of influenza virus, thereby preventing or treating infection of influenza virus and also preventing or treating infection of influenza virus resistant to antiviral agents. Accordingly, the conjugate may be widely used in the development of prophylactic or therapeutic agents for influenza virus infection.
    Type: Application
    Filed: August 17, 2017
    Publication date: February 22, 2018
    Inventors: Jong Hwan Kwak, Kyung Bok Lee, Jong-Hwan Park, Dong Hee Na, Seok-Joon Kwon, Robert J. Linhardt, Jonathan S. Dordick, Fuming Zhang
  • Publication number: 20110190162
    Abstract: The invention is directed to a three-dimensional cell culture array comprising spatially-separated matrices attached to a solid support, wherein a plurality of said matrices encapsulate cells transfected with nucleic acids, method for the preparation of the array and methods reducing the expression of a target gene.
    Type: Application
    Filed: November 12, 2010
    Publication date: August 4, 2011
    Inventors: Moo-Yeal Lee, Seok Joon Kwon, Jonathan S. Dordick, Douglas S. Clark, Jessica R. McKinley
  • Publication number: 20090317943
    Abstract: The present invention relates to a method for aligning semiconducting nanowires on a metal electrode (12), more particularly to a method for aligning semiconducting nanowires on a metal electrode (12) by which a zinc oxide nanowire and a silicon nanowire are synthesized on a specific region of an electrode made of Al, Ti, Pt, etc. and the nanowires are aligned on the wafer scale instantly as they are synthesized. The method for aligning semiconducting nanowires on a metal electrode (12) in accordance with the present invention makes it possible to manufacture multiple nanowire devices at low cost. Thus, the method in accordance with the present invention can be effectively utilized to produce various nano devices, including electronic devices, optoelectronic devices, laser devices, chemical sensors, etc. in large quantity.
    Type: Application
    Filed: November 28, 2006
    Publication date: December 24, 2009
    Inventors: Kyung Soo Park, Seok Joon Kwon, Jae Gwan Park, Jae-Hwan Park, Young Jin Choi, Hae Young Kang
  • Publication number: 20050176096
    Abstract: The present invention relates to a biocatalyst displayed on spore or virus surface and a method of bioconversion using the same, in particular to a method of bioconversion using a biocatalyst, which comprises the steps of: (a) preparing a vector for spore surface display comprising a gene construct containing a gene encoding a display motif and a gene encoding the biocatalyst, wherein, when expressed, the gene construct expresses the display motif and the biocatalyst in a fusion form and the biocatalyst is displayed on a spore surface; (b) transforming a host cell with the vector for spore surface display; (c) displaying the biocatalyst on the spore surface of the host cell; (d) recovering the spore displaying on its surface the biocatalyst; and (e) performing the bioconversion reaction using the spore displaying on its surface the biocatalyst, and a biocatalyst.
    Type: Application
    Filed: April 9, 2002
    Publication date: August 11, 2005
    Inventors: Seok-Joon Kwon, Soo Keun Choi, Heung Chae Jung, Jae Gu Pan, Joon Sung Chang, Tae Jung Park