Patents by Inventor Seokjoo YOON
Seokjoo YOON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12209916Abstract: The present invention relates to a composition for temperature sensors including graphene oxide, DNAzyme and PNA, a temperature sensing method and a kit using the same. In the present invention, when the DNAzyme/PNA duplex is dissociated at a certain temperature, graphene oxide adsorbs PNA with excellent selectivity and irreversibility, enabling recall of temperature, to permit delayed color development in the time of need. Also, the target temperature can be easily and quickly detected with the naked eye through the color change of the colorimetric reagent, and the thermosensor is technically convenient and easy to apply, so it can be used in various biological applications. Moreover, it can be used as a barcode (on/off) system using a combination of PNA probes with various lengths, and thus can be broadly applied to sensing a diverse range of temperatures.Type: GrantFiled: September 16, 2020Date of Patent: January 28, 2025Assignee: Korea Research Institute of Chemical TechnologyInventors: Jieon Lee, Woo-keun Kim, Seokjoo Yoon
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Publication number: 20240219333Abstract: The present invention provides an impedance-based organoid evaluation system comprising an organoid deformation generating unit including a first tube and a plurality of second tubes having a diameter smaller than that of the first tube, connected to one end of the first tube or inserted therein; and an impedance measuring unit connected to the organoid deformation generating unit and including an impedance analyzer for measuring the impedance of the organoid, and evaluating the organoid from the impedance measured by the impedance measuring unit.Type: ApplicationFiled: June 15, 2021Publication date: July 4, 2024Inventors: Jung-Hwa Oh, Jaehwan Ahn, Seokjoo Yoon, Hyoung-Yun Han, Mi Young Son, Kwang Bo Jung, Cho Rok Jung, Janghwan Kim
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Publication number: 20240148810Abstract: The present invention relates to an anti-inflammatory composition comprising Epimedium koreanum Nakai, Polygala tenuifolia Willd, and Polyporus umbellatus Fries extracts or a mixture thereof as an active ingredient. The extracts and mixture prepared according to the present invention exhibit a high inhibitory effect against nitric oxide and a suppressive effect against the expression of iNOS and COX2 and thus can be advantageously used as an anti-inflammatory composition.Type: ApplicationFiled: March 19, 2021Publication date: May 9, 2024Applicant: Korea Research Institute of Chemical TechnologyInventors: Hyoung-Yun Han, Jung-Hwa Oh, Seokjoo Yoon, Se-Myo Park, Mi-Sun Choi, Soojin Kim
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Patent number: 11814672Abstract: The present invention provides a complex of LNA probe and graphene oxide, and a nucleic acid detection method using the same. In the present invention, LNA-containing molecular beacon is conjugated through covalent bonding with graphene oxide, a single strand of the molecular beacon binds to a target nucleic acid to form a complex, and the complex is separated from graphene oxide to induce a fluorescence signal. The molecular beacon and graphene oxide can be covalently bonded to minimize non-specific signals, and a LNA-added molecular beacon is designed in a double strand to detect a very low concentration of target nucleic acid with high sensitivity, as well as a fluorescent signal, and the multiple target nucleic acids can be detected simultaneously through diversification of the fluorescent signal to enable easy and accurate detection of a nucleic acid biomarker whose specific expression level is specifically changed according to diseases and disease progression.Type: GrantFiled: August 30, 2020Date of Patent: November 14, 2023Assignee: Korea Research Institute of Chemical TechnologyInventors: Jieon Lee, Woo-keun Kim, Seokjoo Yoon, Bomi Shin
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Patent number: 11624087Abstract: The present invention relates to a composition for detecting nucleic acid comprising duplex molecular beacon and graphene oxide and a colorimetric signal enhancement method of detecting nucleic acid using the same. According to the composition, kit and method for detecting nucleic acid of the present invention, a complex can be formed by adsorbing a single strand having a DNAzyme sequence dissociated from the conjugate of a duplex molecular beacon and a target nucleic acid to the graphene oxide surface, and separated, and a colorimetric signal amplified therefrom can be induced, so that a very low concentration of target nucleic acid can be detected with high efficiency and the target nucleic acid can be detected quickly and easily in seconds. Therefore, a new colorimetric target nucleic acid detection system capable of point of care testing (POCT) can be provided.Type: GrantFiled: September 22, 2020Date of Patent: April 11, 2023Assignee: Korea Research Institute of Chemical TechnologyInventors: Jieon Lee, Woo-keun Kim, Sangwoo Lee, Seokjoo Yoon
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Publication number: 20230093162Abstract: The present invention relates to a fatty liver and liver fibrosis evaluation system based on impedance. The fatty liver and liver fibrosis evaluation system based on impedance provided in one aspect of the present invention uses 3-dimensional liver microtissues so that the fatty liver formation and the stiffness changes resulted from liver fibrosis induced by a test drug can be analyzed with non-invasive and highly reproducible manner.Type: ApplicationFiled: November 28, 2022Publication date: March 23, 2023Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYInventors: Jung-Hwa Oh, Jaehwan Ahn, Seokjoo Yoon, Jun-Ho Ahn, Heeyoung Yang, Hyoung-Yun Han
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Patent number: 11166891Abstract: The present invention relates to a bis phenyl hexa triene derivative, a preparation method thereof and a composition for skin whitening comprising the same as an active ingredient. The said derivative inhibits the expression of tyrosinase, TRP 1 (tyrosinase-related protein 1), TRP 2 (tyrosinase-related protein 2) or MITF (microphthalmia-associated transcription factor) gene which produces a precursor necessary for the generation of melanin, suppresses the activity of tyrosinase, eventually inhibits the biosynthesis of melanin, is safe due to low cytotoxicity, and has less side effects and excellent antioxidative effect, so that it can be effectively used as a composition for skin whitening.Type: GrantFiled: September 5, 2019Date of Patent: November 9, 2021Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYInventors: Woo-Keun Kim, Sangwoo Lee, Seokjoo Yoon, Chul Min Park
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Publication number: 20210324471Abstract: The present invention provides a complex of LNA probe and graphene oxide, and a nucleic acid detection method using the same. In the present invention, LNA-containing molecular beacon is conjugated through covalent bonding with graphene oxide, a single strand of the molecular beacon binds to a target nucleic acid to form a complex, and the complex is separated from graphene oxide to induce a fluorescence signal. The molecular beacon and graphene oxide can be covalently bonded to minimize non-specific signals, and a LNA-added molecular beacon is designed in a double strand to detect a very low concentration of target nucleic acid with high sensitivity, as well as a fluorescent signal, and the multiple target nucleic acids can be detected simultaneously through diversification of the fluorescent signal to enable easy and accurate detection of a nucleic acid biomarker whose specific expression level is specifically changed according to diseases and disease progression.Type: ApplicationFiled: August 30, 2020Publication date: October 21, 2021Applicant: Korea Research Institute of Chemical TechnologyInventors: Jieon LEE, Woo-keun KIM, Seokjoo YOON
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Publication number: 20210080333Abstract: The present invention relates to a composition for temperature sensors including graphene oxide, DNAzyme and PNA, a temperature sensing method and a kit using the same. In the present invention, when the DNAzyme/PNA duplex is dissociated at a certain temperature, graphene oxide adsorbs PNA with excellent selectivity and irreversibility, enabling recall of temperature, to permit delayed color development in the time of need. Also, the target temperature can be easily and quickly detected with the naked eye through the color change of the colorimetric reagent, and the thermosensor is technically convenient and easy to apply, so it can be used in various biological applications. Moreover, it can be used as a barcode (on/off) system using a combination of PNA probes with various lengths, and thus can be broadly applied to sensing a diverse range of temperatures.Type: ApplicationFiled: September 16, 2020Publication date: March 18, 2021Applicant: Korea Research Institute of Chemical TechnologyInventors: Jieon LEE, Woo-keun KIM, Seokjoo YOON
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Publication number: 20210002695Abstract: The present invention relates to a composition for detecting nucleic acid comprising duplex molecular beacon and graphene oxide and a colorimetric signal enhancement method of detecting nucleic acid using the same. According to the composition, kit and method for detecting nucleic acid of the present invention, a complex can be formed by adsorbing a single strand having a DNAzyme sequence dissociated from the conjugate of a duplex molecular beacon and a target nucleic acid to the graphene oxide surface, and separated, and a colorimetric signal amplified therefrom can be induced, so that a very low concentration of target nucleic acid can be detected with high efficiency and the target nucleic acid can be detected quickly and easily in seconds. Therefore, a new colorimetric target nucleic acid detection system capable of point of care testing (POCT) can be provided.Type: ApplicationFiled: September 22, 2020Publication date: January 7, 2021Applicant: Korea Research Institute of Chemical TechnologyInventors: Jieon LEE, Woo-keun KIM, Sangwoo LEE, Seokjoo YOON
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Patent number: 10683483Abstract: A microfabricated platform for mimicking the liver zonation and an evaluating method of zone-specific hepatotoxicity using the same is provided. The microfabricated platform for mimicking the liver zonation prepared according to the method of the present invention is divided into three zones of zone 1, zone 2 and zone 3 similarly to in vivo liver tissue and thus the zone-specific hepatotoxicity of a drug in the liver can be evaluated using the same. According to the present invention, the zone-specific hepatotoxicity results can be analyzed quantitatively by using image analysis, so that the platform of the present invention can be effectively used for in vitro screening of zone-specific hepatotoxicity.Type: GrantFiled: March 5, 2019Date of Patent: June 16, 2020Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYInventors: Jung-Hwa Oh, Jaehwan Ahn, Seokjoo Yoon, Heeyoung Yang, Jun-Ho Ahn, Mi-Sun Choi, Soojin Kim, Se-Myo Park, Hyoung-Yun Han
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Publication number: 20200132670Abstract: The present invention relates to a fatty liver and liver fibrosis evaluation system based on impedance. The fatty liver and liver fibrosis evaluation system based on impedance provided in one aspect of the present invention uses 3-dimensional liver microtissues so that the fatty liver formation and the stiffness changes resulted from liver fibrosis induced by a test drug can be analyzed with non-invasive and highly reproducible manner.Type: ApplicationFiled: April 24, 2019Publication date: April 30, 2020Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYInventors: Jung-Hwa Oh, Jaehwan Ahn, Seokjoo Yoon, Jun-Ho Ahn, Heeyoung Yang, Hyoung-Yun Han
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Publication number: 20200078279Abstract: The present invention relates to a bis phenyl hexa triene derivative, a preparation method thereof and a composition for skin whitening comprising the same as an active ingredient. The said derivative inhibits the expression of tyrosinase, TRP 1 (tyrosinase-related protein 1), TRP 2 (tyrosinase-related protein 2) or MITF (microphthalmia-associated transcription factor) gene which produces a precursor necessary for the generation of melanin, suppresses the activity of tyrosinase, eventually inhibits the biosynthesis of melanin, is safe due to low cytotoxicity, and has less side effects and excellent antioxidative effect, so that it can be effectively used as a composition for skin whitening.Type: ApplicationFiled: September 5, 2019Publication date: March 12, 2020Inventors: Woo-Keun Kim, Sangwoo Lee, Seokjoo Yoon, Chul Min Park
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Publication number: 20190276799Abstract: A microfabricated platform for mimicking the liver zonation and an evaluating method of zone-specific hepatotoxicity using the same is provided. The microfabricated platform for mimicking the liver zonation prepared according to the method of the present invention is divided into three zones of zone 1, zone 2 and zone 3 similarly to in vivo liver tissue and thus the zone-specific hepatotoxicity of a drug in the liver can be evaluated using the same. According to the present invention, the zone-specific hepatotoxicity results can be analyzed quantitatively to by using image analysis, so that the platform of the present invention can be effectively used for in vitro screening of zone-specific hepatotoxicity.Type: ApplicationFiled: March 5, 2019Publication date: September 12, 2019Applicant: Korea Research Institute of Chemical TechnologyInventors: Jung-Hwa OH, Jaehwan AHN, Seokjoo YOON, Heeyoung YANG, Jun-Ho AHN, Mi-Sun CHOI, Soojin KIM, Se-Myo PARK, Hyoung-Yun Han