Abstract: Provided is a method for manufacturing a composition for increasing cognitive function.

Abstract: Provided is a pharmaceutical composition for treating a degenerative brain disease, including a glycine transporter as an active ingredient. A composition including, as an active ingredient, a glycine transporter protein, a fragment thereof or a nucleic acid molecule encoding the protein or the fragment thereof, a vector including the nucleic acid molecule, or a cell transformed with the vector including the nucleic acid molecule, according to an embodiment, not only can achieve excellent effect(s) of inhibiting amyloid-beta aggregation and/or degrading aggregated amyloid-beta, but also degrades tau protein (and/or inhibition of the aggregation thereof), inhibits the hyperphosphorylation of tau protein, and has excellent blood-brain barrier permeability, thus making it possible to successively act on brain tissues.

Abstract: Provided are a novel pharmaceutical composition and method for the inhibition and/or degradation of amyloid aggregation, and/or degradation of Tau, and/or inhibition of Tau phosphorylation, and/or the prevention and/or treatment of neurodegenerative brain disease.