Abstract: The present disclosure relates to a pharmaceutical composition for preventing or treating viral infections, containing a piperlongumine-based compound as an active ingredient. Specifically, the piperlongumine-based compound according to the present disclosure inhibits SARS-CoV-2 infection, and thus can be useful for treating viral infections, particularly RNA viral infections.

Abstract: Disclosed are a novel piperlongumine-based compound, an immuno regulator containing as an active ingredient the compound, or a pharmaceutically acceptable salt or solvate thereof, and a health functional food for immune regulation.

Abstract: The present disclosure relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases, the pharmaceutical composition including a fermented steam-dried ginseng berry as an active ingredient. Specifically, the fermented steam-dried ginseng berry may have a high total ginsenoside and polyphenol content, exhibit antioxidant activity, inhibit acetylcholinesterase, improve cognitive function and spatial perception in animal model of dementias, recover acetylcholine expression and inhibit accumulation of amyloid-beta in brain tissue of the animal model of dementias, inhibit brain damage in animal model of dementias, and promote expression of genes related to brain damage in neuronal cell lines, and accordingly, the fermented steam-dried ginseng berry may be used to treat neurodegenerative diseases, improve cognitive function, and protect brain cells.

Abstract: The present invention provides a composition for treating atopic dermatitis, the composition containing, as an active ingredient, a butanol fraction of an S. fusiforme extract.

Abstract: Disclosed are a novel piperlongumine-based compound, an immuno regulator containing as an active ingredient the compound, or a pharmaceutically acceptable salt or solvate thereof, and a health functional food for immune regulation.

Abstract: An aspect of the present invention provides a pharmaceutical composition containing Camellia japonica extract derived from a natural substance as an active ingredient for prevention and treatment of viral infection, wherein the extract inhibits viral replication and release from cells to effectively regulate viral infection, thus exhibiting an excellent antiviral effect.

Abstract: The present disclosure relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases, the pharmaceutical composition including a fermented steam-dried ginseng berry as an active ingredient. Specifically, the fermented steam-dried ginseng berry may have a high total ginsenoside and polyphenol content, exhibit antioxidant activity, inhibit acetylcholinesterase, improve cognitive function and spatial perception in animal model of dementias, recover acetylcholine expression and inhibit accumulation of amyloid-beta in brain tissue of the animal model of dementias, inhibit brain damage in animal model of dementias, and promote expression of genes related to brain damage in neuronal cell lines, and accordingly, the fermented steam-dried ginseng berry may be used to treat neurodegenerative diseases, improve cognitive function, and protect brain cells.

Abstract: The present invention provides a composition for treating atopic dermatitis, the composition containing, as an active ingredient, a butanol fraction of an S. fusiforme extract.

Abstract: Provided is a functional cosmetic composition of white rose extract and a gartanin derivative compound isolated therefrom, and specifically, to a cosmetic composition for skin whitening and skin wrinkle alleviation containing, as active ingredients, white rose petal extract and gartanin derivative compounds isolated therefrom. The white rose extract and gartanin derivative compound, according to the present invention, are safe without causing side effects on the skin, prevent melanin production through a mechanism inhibiting tyrosinase activity, thereby having a whitening effect, and exhibit a wrinkle alleviation effect by a mechanism inhibiting MMP-1 activity, and thus the composition, of the present invention, containing the same as active ingredients, can be utilized as a material for functional cosmetics for skin whitening and wrinkle alleviation without causing skin irritation.

Abstract: Provided is a functional cosmetic composition of white rose extract and a gartanin derivative compound isolated therefrom, and specifically, to a cosmetic composition for skin whitening and skin wrinkle alleviation containing, as active ingredients, white rose petal extract and gartanin derivative compounds isolated therefrom. The white rose extract and gartanin derivative compound, according to the present invention, are safe without causing side effects on the skin, prevent melanin production through a mechanism inhibiting tyrosinase activity, thereby having a whitening effect, and exhibit a wrinkle alleviation effect by a mechanism inhibiting MMP-1 activity, and thus the composition, of the present invention, containing the same as active ingredients, can be utilized as a material for functional cosmetics for skin whitening and wrinkle alleviation without causing skin irritation.

Abstract: Disclosed is a composition for enhancing alcohol metabolism in a subject, who overdrank, the composition comprises an effective amount of ginsenoside-free extract of steam-dried Korean ginseng berry (GFM) and one or more pharmaceutically or sitologically acceptable carriers. The composition of the present disclosure may be effective for alleviating hangover according to overdrink and for protecting liver from alcoholic injure.

Abstract: Provided is a functional cosmetic composition of white rose extract and a gartanin derivative compound isolated therefrom, and specifically, to a cosmetic composition for skin whitening and skin wrinkle alleviation containing, as active ingredients, white rose petal extract and gartanin derivative compounds isolated therefrom. The white rose extract and gartanin derivative compound, according to the present invention, are safe without causing side effects on the skin, prevent melanin production through a mechanism inhibiting tyrosinase activity, thereby having a whitening effect, and exhibit a wrinkle alleviation effect by a mechanism inhibiting MMP-1 activity, and thus the composition, of the present invention, containing the same as active ingredients, can be utilized as a material for functional cosmetics for skin whitening and wrinkle alleviation without causing skin irritation.

Abstract: The present invention relates to a pharmaceutical composition for treating Alzheimer's disease and improving cognitive function of Alzheimer's patients, and more specifically for pharmaceutical composition for treating Alzheimer's disease and improving cognitive function of Alzheimer's patients comprising ginsenoside complex prepared by sequential fraction of steam-dried unripened ginseng berries using solvents and used thereof.

Abstract: Disclosed is a composition for enhancing alcohol metabolism in a subject, who overdrank, the composition comprises an effective amount of ginsenoside-free extract of steam-dried Korean ginseng berry (GFM) and one or more pharmaceutically or sitologically acceptable carriers. The composition of the present disclosure may be effective for alleviating hangover according to overdrink and for protecting liver from alcoholic injure.

Abstract: In a peer aware communication network, a method in which a peer device accesses a link includes: determining a phase based on service which is provided to another peer device; and accessing a link which is included in a superframe that a predetermined length according to the phase, a method of reserving resources and a method of avoiding interference are provided.

Abstract: The present invention relates to a method for detecting neuronal injury in a mammalian subject. The biomarker of this invention specifically increases in serum of the mammalian that has neuronal injuries. In addition, the biomarker of this invention permits to identify and predict neuronal injuries.

Abstract: The present invention relates to a composition for treating atopic dermatitis comprising hirsutenone as an active ingredient. Hirsutenone as the active ingredient of the present composition decreases the number of eosinophil and the level of IgE increased in atopic dermatitis and remarkably reduces expression amounts of immune regulatory cytokine (e.g., IL-4, IL-5 and IL-13) associated with atopic dermatitis. In addition, hirsutenone decreases COX-2 and iNOS expression. Hirsutenone as the active ingredient of the present composition could be effectively used in drugs, cosmetics and foods for treating atopic dermatitis or relieving a symptom of atopic dermatitis.

Abstract: The present invention relates to a composition for treating atopic dermatitis comprising hirsutanonol as an active ingredient. Hirsutanonol or oregonin as the active ingredient of the present composition decreases the number of eosinophil increased in atopic dermatitis and regulates expression amounts of immune regulatory cytokines, IL-4, IL-5, IL-10 and IL-13 associated with atopic dermatitis. In addition, hirsutanonol and oregonin increase MBD (mouse beta-defensin)-1, MBD-2 and MBD-3 expression and decrease COX-2 and iNOS expression in mouse animal model of atopic dermatitis. Hirsutanonol and oregonin as the active ingredient of the present composition could be effectively used in drugs, cosmetics and foods for treating atopic dermatitis.

Abstract: The present invention relates to a composition for treating atopic dermatitis comprising hirsutenone as an active ingredient. Hirsutenone as the active ingredient of the present composition decreases the number of eosinophil and the level of IgE increased in atopic dermatitis and remarkably reduces expression amounts of immune regulatory cytokine (e.g., IL-4, IL-5 and IL-13) associated with atopic dermatitis. In addition, hirsutenone decreases COX-2 and iNOS expression. Hirsutenone as the active ingredient of the present composition could be effectively used in drugs, cosmetics and foods for treating atopic dermatitis or relieving a symptom of atopic dermatitis.

Abstract: The present invention relates to a composition for preventing and treating climacteric symptoms comprising the extract of Sophorae Fructus as an effective ingredient. Precisely, the present invention relates to the extract of Sophorae Fructus having an effect of preventing and treating climacteric symptoms, a composition comprising the extract and a method for preventing and treating climacteric symptoms by administering the composition. The extract of Sophorae Fructus of the present invention has activities of promoting the osteoblast proliferation, inhibiting the secretion of bone-absorptive cytokines, promoting the secretion of growth factors involved in bone-reformation, stimulating the generation of nitric oxide in osteoblasts and inhibiting the osteoclast differentiation. In addition, the extract also reduces the concentration of a bone absorption index and inhibits the decrease of calcium content and bone density.