Abstract: A prosthesis delivery system having a balloon catheter with an inflatable balloon on its exterior. The balloon is inflatable by injection of fluid through a lumen in the catheter and the balloon is initially partially constrained against inflation by a constraint. A tubular prosthesis is disposed on the catheter over at least a portion of the balloon and a portion of the constraint. The tubular prosthesis has a contracted condition and an expanded condition. The tubular prosthesis is initially disposed on the catheter in the contracted condition. Further, a balloon catheter includes a constraint so that the balloon may be sequentially inflated for dilatation purposes such as in a valvuloplasty operation.

Abstract: Implantable medical device having a structure adapted for introduction into a patient wherein the structure is composed of a base material positioned over the structure. The implantable medical device further includes at least one composite layer of a bioactive agent and a polymer material and at least a barrier layer positioned over the composite layer and being of thickness adequate to provide a controlled release of the bioactive agent. The barrier layer being applied by a low energy plasma polymerization process which includes placing the device with the at least one composite layer in a plasma chamber and introducing at least one monomer gas.

Abstract: A vascular filter comprises an emboli-capturing portion having a set of helical filter-wires joined at a central region and extending in a given direction along the blood vessel in a diverging relationship to the axis of the filter, the wires terminating in free ends constructed to engage the walls of said vessel. A major mid-portion of the length of the free ended wires are of generally helical form, cooperatively related to form an effective emboli capturing array. Anchoring is accomplished by a separate assembly formed of struts and anchoring devices. A parallelogram supporting strut assembly and other means for providing linear engagement with the wall of the vena cava are shown. The parallelogram structure is shown to have filter capability by itself as well.

Abstract: Implantable medical device having a structure adapted for introduction into a patient wherein the structure is composed of a base material positioned over the structure. The implantable medical device further includes at least one composite layer of a bioactive agent and a polymer material and at least a barrier layer positioned over the composite layer and being of thickness adequate to provide a controlled release of the bioactive agent. The barrier layer being applied by a low energy plasma polymerization process which includes placing the device with the at least one composite layer in a plasma chamber and introducing at least one monomer gas.

Abstract: A prosthesis delivery system having a balloon catheter with an inflatable balloon on its exterior. The balloon is inflatable by injection of fluid through a lumen in the catheter and the balloon is initially partially constrained against inflation by a constraint. A tubular prosthesis is disposed on the catheter over at least a portion of the balloon and a portion of the constraint. The tubular prosthesis has a contracted condition and an expanded condition. The tubular prosthesis is initially disposed on the catheter in the contracted condition. Further, a balloon catheter includes a constraint so that the balloon may be sequentially,inflated for dilatation purposes such as in a valvuloplasty operation.

Abstract: Implantable medical device having a structure adapted for introduction into a patient wherein the structure is composed of a base material positioned over the structure. The implantable medical device further includes at least one composite layer of a bioactive agent and a polymer material and at least a barrier layer positioned over the composite layer and being of thickness adequate to provide a controlled release of the bioactive agent. The barrier layer being applied by a low energy plasma polymerization process which includes placing the device with the at least one composite layer in a plasma chamber and introducing at least one monomer gas.

Abstract: A prosthesis delivery system having a balloon catheter with an inflatable balloon on its exterior. The balloon is inflatable by injection of fluid through a lumen in the catheter and the balloon is initially partially constrained against inflation by a constraint. A tubular prosthesis is disposed on the catheter over at least a portion of the balloon and a portion of the constraint. The tubular prosthesis has a contracted condition and an expanded condition. The tubular prosthesis is initially disposed on the catheter in the contracted condition. Further, a balloon catheter includes a constraint so that the balloon may be sequentially inflated for dilatation purposes such as in a valvuloplasty operation.

Abstract: A blood clot filter comprising: an anchoring portion comprising a generally cylindrical self-expanding body formed from resilient material, the generally cylindrical body having proximal and distal ends and defining an axial direction and having a structure of variable size diameter expandable from a low-profile compressed condition to a larger profile expanded condition, wherein the resilient material urges the generally cylindrical body to radially expand and to thereby apply anchoring radial force against the inner wall surface of the blood vessel; and a generally conical filtering portion axially aligned with the generally cylindrical body having an open proximal end coupled to the distal end of the anchoring portion and having an apical distal end. Also disclosed is a blood clot filter having one or more hooks fixedly coupled to the anchoring portion and formed from compliant material having an original shape that bends under stress yet returns to its original shape when unstressed.

Abstract: A self-centering blood clot filter is provided. The filter includes an anchoring portion including a generally cylindrical radially expandable body including an axial lumen extending therethrough. The filter further includes a filtering portion including a conical body concentrically aligned within the axial lumen of the anchoring portion. The conical body of the filtering portion is tapered to form a distal tip. As such, the blood clot filter can be properly centered within the lumen of a vessel for effective lysing of blood clots.

Abstract: A vascular filter-comprises an emboli-capturing portion having a set of helical filter-wires joined at a central region and extending in a given direction along the blood vessel in a diverging relationship to the axis of the filter, the wires terminating in free ends constructed to engage the walls of said vessel. A major mid-portion of the length of the free ended wires are of generally helical form, cooperatively related to form an effective emboli capturing array. Anchoring is accomplished by a separate assembly formed of struts and anchoring devices. A parallelogram supporting strut assembly and other members for providing linear engagement with the wall of the vena cava are shown. The parallelogram structure is shown to have filter capability by itself as well.

Abstract: This invention is a blood clot filter having an anchoring portion (402) which includes a generally cylindrical self-expanding body. A generally conical filtering portion (400) is axially aligned with the cylindrical body (402), has an open proximal end (406) coupled to a distal end of the anchoring portion, and an apical distal end (404). In a preferred embodiment, the filter portion (400) is formed from strands (410) of resilient material that extend from the apical distal end (404) to the open proximal end (406). The strands (410) form twisted pairs (408) that converge at the apical distal end (404). The strands (410) diverge from the twisted pairs (408) in crossing paths to form a pattern of open filtering cells (A)(B)(C). The filter also has hooks (413) coupled to the anchoring portion (402) and formed from compliant material having an original shaped that bends under stress yet returns to its original shaped when unstressed.

Abstract: A prosthesis delivery system having a balloon catheter with an inflatable balloon on its exterior. The balloon is inflatable by injection of fluid through a lumen in the catheter and the balloon is initially partially constrained against inflation by a constraint. A tubular prosthesis is disposed on the catheter over at least a portion of the balloon and a portion of the constraint. The tubular prosthesis has a contracted condition and an expanded condition. The tubular prosthesis is initially disposed on the catheter in the contracted condition. Further, a balloon catheter includes a constraint so that the balloon may be sequentially inflated for dilatation purposes such as in a valvuloplasty operation.

Abstract: A vascular filter comprises an emboli-capturing portion having a set of helical filter-wires joined at a central region and extending in a given direction along the blood vessel in a diverging relationship to the axis of the filter, the wires terminating in free ends constructed to engage the walls of said vessel. A major mid-portion of the length of the free ended wires are of generally helical form, cooperatively related to form an effective emboli capturing array. Anchoring is accomplished by a separate assembly formed of struts and anchoring devices. A parallelogram supporting strut assembly and other means for providing linear engagement with the wall of the vena cava are shown. The parallelogram structure is shown to have filter capability by itself as well.

Abstract: A blood clot filter including an anchoring portion including a generally cylindrical self-expanding body formed from resilient material, the generally cylindrical body having proximal and distal ends and defining an axial direction and having a structure of variable size diameter expandable from a low-profile compressed condition to a larger profile expanded condition, wherein the resilient material urges the generally cylindrical body to radially expand and to thereby apply anchoring radial force against the inner wall surface of the blood vessel; and a generally conical filtering portion axially aligned with the generally cylindrical body having an open proximal end coupled to the distal end of the anchoring portion and having an apical distal end. Also disclosed is a blood clot filter having one or more hooks fixedly coupled to the anchoring portion and formed from compliant material having an original shape that bends under stress yet returns to its original shape when unstressed.

Abstract: A prosthesis delivery system having a balloon catheter with an inflatable balloon on its exterior. The balloon is inflatable by injection of fluid through a lumen in the catheter and the balloon is initially partially constrained against inflation by a constraint. A tubular prosthesis is disposed on the catheter over at least a portion of the balloon and a portion of the constraint. The tubular prosthesis has a contracted condition and an expanded condition. The tubular prosthesis is initially disposed on the catheter in the contracted condition. Further, a balloon catheter includes a constraint so that the balloon may be sequentially inflated for dilatation purposes such as in a valvuloplasty operation.

Abstract: A solid state power controller for switching power on and off to an electrical load which also serves as a circuit protection device protecting the load and/or the wire connected between the load output terminal of the controller and ground from thermal damage due to current overload is shown. When a current overload exists the controller interrupts current to the load in a time inversely proportional to the square of the magnitude of the overload as shown in a trip time vs load current curve. The controller also limits the load current to a selected maximum level by controlling the drain-source resistance of power MOSFETs used for switching the power. A secondary interrupt is provided in the event that the junction temperature of the MOSFETs has risen a selected maximum level. A thermal memory feature is included for both interrupt signals. The controller is controlled by a single on/off input line and provides both a status and trip output line to indicate its state.

Abstract: A solid state power controller for switching power on and off to an electrical load which also serves as a circuit protection device protecting the load and/or the wire connected between the load output terminal of the controller and ground from thermal damage due to current overload is shown. When a current overload exists the controller interrupts current to the load in a time inversely proportional to the square of the magnitude of the overload as shown in a trip time vs load current curve. The controller also limits the load current to a selected maximum level by controlling the drain-source resistance of power MOSFETs used for switching the power. A secondary interrupt is provided in the event that the junction temperature of the MOSFETs has risen a selected maximum level. A thermal memory feature is included for both interrupt signals. The controller is controlled by a single on/off input line and provides both a status and trip output line to indicate its state.

Abstract: A protective circuit capable of remotely switching power to a load on and off and including an electrothermal sensor system having a heating element of predetermined resistance in series with the load and source of power whereby the temperature of the heating element is monitored relative to ambient temperature to determine current flow in the heater. The electrothermal sensor, according to one embodiment, includes a ceramic substrate having the heater formed thereon with a first deposited heat monitoring element thereon for monitoring the temperature of the heater and a second heat monitoring element thereon for monitoring the ambient temperature of the substrate remote from the heater. The electrothermal sensor, according to a second embodiment, includes a layer of electrically conductive material, a backing layer thereon of electrically insulating material, a grid on the backing layer of thermoresponsive material to form RTDs and a second layer of electrically insulating material over said grid.

Abstract: An electrothermal sensor is shown having an electrically conductive substrate, an electrically insulating layer disposed on the substrate, a first thermistor disposed on a central region of the electrically insulating layer, a second thermistor disposed adjacent an edge of the electrically insulating layer, an electrical coupling device on the electrically insulating layer for coupling the first and second thermistors externally of the electrically insulating layer and a pair of electrical connecting devices coupled to the substrate and passing through the electrically insulating layer, the first thermistor being disposed between the pair of electrical connecting devices.

Abstract: A seal for a blood processing centrifuge bowl which is formed of a dynamic rotary seal and a static seal. The dynamic rotary seal is formed of an upper graphite or carbon non-rotating ring member and a lower two-piece rotatable ring member formed of a ceramic bearing surface bonded by adhesive to a plastic adapter ring. The static seal is comprised of an elastomeric diaphragm formed over the upper ring member and secured thereto by a plastic retaining ring.