Abstract: Described herein are doppel-targeting molecules (e.g., antibodies) useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

Abstract: A method of discovery a drug based on bioactivity data includes extracting, by the analysis apparatus, bioassay data from a bioassay database, classifying, by the analysis apparatus, a plurality of candidate compounds included in the bioassay data into a similar compound group and a dissimilar compound group based on similarity with the target compound, calculating, by the analysis apparatus, a relative activity score (RAS) based on activity information on compounds belonging to the similar compound group and the dissimilar compound group; and selecting, by the analysis apparatus, at least some of the plurality of candidate compounds included in the bioassay data as a drug candidate substance based on the RAS.