Patents by Inventor Serafina Guadagnuolo

Serafina Guadagnuolo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Promoters for increased protein expression in meningococcus
    Patent number: 9657297
    Abstract: New promoters are described to drive transcription in meningococcus e.g. for over-expression of protein antigens for retention in membrane vesicles. Modified porA promoters lack the wild-type poly-G sequence which can cause phase variation. Meningococcal rRNA-coding genes (e.g. for 16S rRNA) can be used to drive transcription of a protein-coding gene. These approaches can be used in combination.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: May 23, 2017
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Isabel Delany, Serafina Guadagnuolo
  • PROMOTERS FOR INCREASED PROTEIN EXPRESSION IN MENINGOCOCCUS
    Publication number: 20150218566
    Abstract: New promoters are described to drive transcription in meningococcus e.g. for over-expression of protein antigens for retention in membrane vesicles. Modified porA promoters lack the wild-type poly-G sequence which can cause phase variation. Meningococcal rRNA-coding genes (e.g. for 16S rRNA) can be used to drive transcription of a protein-coding gene. These approaches can be used in combination.
    Type: Application
    Filed: February 1, 2013
    Publication date: August 6, 2015
    Inventors: Isabel Delany, Serafina Guadagnuolo