Patents by Inventor SERBAN I. CIOTIOS

SERBAN I. CIOTIOS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200276289
    Abstract: A personalized cancer vaccine is disclosed. The vaccine is comprised of particles encapsulating neoantigens. The neoantigens are chosen by predicting whether a first neoantigen or a second neoantigen of an individual cancer patient has a stronger binding affinity for a human leukocyte antigen (HLA) complex of the patient and using the neoantigen with the stronger predicted binding affinity. Such a predicting step includes artificial intelligence, statistical modeling, or a combination thereof. Placing the antigen in a particular sized particle is referred to here as Size Exclusion Antigen Presentation Control, (SEAPAC) used in methods of treating the patient using such a personalized cancer vaccine.
    Type: Application
    Filed: March 2, 2020
    Publication date: September 3, 2020
    Applicant: FLOW PHARMA, INC.
    Inventors: REID M. RUBSAMEN, CHARLES V. HERST, LU WANG, SCOTT R. BURKHOLZ, RICHARD T. CARBACK, III, SERBAN I. CIOTIOS