Patents by Inventor Serena Carosso

Serena Carosso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibacterial monobactams
    Patent number: 11400079
    Abstract: Bromine induced lactamization of vinyl acetohydroxamates facilitated syntheses of monocyclic ?-lactams suitable for incorporation of a thiomethyl and extended functionality at the C(4) position. Elaboration of the resulting substituted N-hydroxy-2-azetidinones allowed incorporation of functionalized ?-amino substituents appropriate for enhancement of antibiotic activity. Evaluation of antibacterial activity against a panel of Gram-positive and Gram-negative bacteria revealed structure-activity-relationships (SAR) and identification of potent new monobactam antibiotics. The corresponding bis-catechol conjugate, 42, has excellent activity against Gram-negative bacteria including carbapenemase and carbacephalosporinase producing strains of Acinetobacter baumannii which have been listed by the WHO as being of critical concern worldwide.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: August 2, 2022
    Assignee: University of Notre Dame du Lac
    Inventors: Marvin J. Miller, Serena Carosso, Rui Liu, Patricia Miller
  • ANTIBACTERIAL MONOBACTAMS
    Publication number: 20200330438
    Abstract: Bromine induced lactamization of vinyl acetohydroxamates facilitated syntheses of monocyclic ?-lactams suitable for incorporation of a thiomethyl and extended functionality at the C(4) position. Elaboration of the resulting substituted N-hydroxy-2-azetidinones allowed incorporation of functionalized ?-amino substituents appropriate for enhancement of antibiotic activity. Evaluation of antibacterial activity against a panel of Gram-positive and Gram-negative bacteria revealed structure-activity-relationships (SAR) and identification of potent new monobactam antibiotics. The corresponding bis-catechol conjugate, 42, has excellent activity against Gram-negative bacteria including carbapenemase and carbacephalosporinase producing strains of Acinetobacter baumannii which have been listed by the WHO as being of critical concern worldwide.
    Type: Application
    Filed: October 2, 2018
    Publication date: October 22, 2020
    Applicant: University of Notre Dame du Lac
    Inventors: Marvin J. MILLER, Serena CAROSSO, Rui LIU, Patricia MILLER
  • Peripherally substituted monocyclic beta-lactams
    Patent number: 9862680
    Abstract: The invention provides monobactams that can be used as antibacterial agents or intermediates for the preparation of other useful compounds such as antibacterial agents.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: January 9, 2018
    Assignee: University of Notre Dame du Lac
    Inventors: Marvin Miller, Serena Carosso
  • PERIPHERALLY SUBSTITUTED MONOCYCLIC BETA-LACTAMS
    Publication number: 20170355671
    Abstract: The invention provides monobactams that can be used as antibacterial agents or intermediates for the preparation of other useful compounds such as antibacterial agents.
    Type: Application
    Filed: June 13, 2016
    Publication date: December 14, 2017
    Applicant: University of Notre Dame du Lac
    Inventors: Marvin Miller, Serena Carosso