Patents by Inventor Serena Nicole Dollive

Serena Nicole Dollive has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
    Patent number: 11951183
    Abstract: Provided herein are adeno-associated virus (AAV) compositions that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell, thereby restoring the PAH gene function. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: April 9, 2024
    Assignee: HOMOLOGY MEDICINES, INC.
    Inventors: Albert Barnes Seymour, Seemin Seher Ahmed, Jason Boke Wright, Serena Nicole Dollive, Hillard Rubin
  • BIDIRECTIONAL DUAL PROMOTER EXPRESSION VECTORS AND USES THEREOF
    Publication number: 20230374546
    Abstract: Provided herein are polynucleotides comprising novel bidirectional dual expression cassettes, recombination adeno-associated virus (rAAV) comprising these polynucleotides, and methods of making and using the polynucleotides and rAAV. Also provided are novel transcriptional control elements (e.g., promoters, enhancers, introns, polyadenylation sequences, and combinations thereof), and novel antibody coding sequences. The compositions and methods disclosed herein are particularly advantageous in that they allow for the efficient expression of two different polypeptides (e.g., an antibody heavy chain and an antibody light chain) in a cell. In particular, they allow for the efficient expression of antibodies (e.g., anti-C5 antibodies) in a subject, for the treatment of diseases (e.g., C5-mediated diseases, such as PNH).
    Type: Application
    Filed: March 10, 2023
    Publication date: November 23, 2023
    Inventors: Carmen BARNES, Yogeshwar Sharma, Omar Francone, Hillard Rubin, Wei Wang, Gustavo Cerqueira, Serena Nicole Dollive, Andrew Pla
  • NON-NATURALLY OCCURRING POLYADENYLATION ELEMENTS AND METHODS OF USE THEREOF
    Publication number: 20230112648
    Abstract: Provided herein are polynucleotides and vectors comprising non-naturally occurring polyadenylation (polyA) sequences, and methods of making and using these polynucleotides and vectors.
    Type: Application
    Filed: September 16, 2022
    Publication date: April 13, 2023
    Inventors: Serena Nicole DOLLIVE, Andrew Pla
  • ADENO-ASSOCIATED VIRUS COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20230045171
    Abstract: Provided herein are novel adeno-associated virus (AAV) capsids, compositions (e.g., rAAV) comprising the capsids, and nucleic acids encoding the capsids. Also provided are methods of making and using the capsids and compositions disclosed herein. The rAAV disclosed herein are particularly useful for gene transfer applications where high transduction efficiency is required (e.g., gene therapy).
    Type: Application
    Filed: June 10, 2022
    Publication date: February 9, 2023
    Inventor: Serena Nicole DOLLIVE
  • ADENO-ASSOCIATED VIRUS COMPOSITIONS FOR RESTORING PAH GENE FUNCTION AND METHODS OF USE THEREOF
    Publication number: 20220325302
    Abstract: Provided herein are adeno-associated virus (AAV) compositions that can restore phenylalanine hydroxylase (PAH) gene function in cell. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
    Type: Application
    Filed: March 25, 2022
    Publication date: October 13, 2022
    Inventors: Albert Barnes SEYMOUR, Seemin Seher AHMED, Jason Boke WRIGHT, Serena Nicole DOLLIVE, James Anthony MCSWIGGEN, Jaime Michelle PROUT, Danielle Lauren SOOKIASIAN
  • ADENO-ASSOCIATED VIRUS COMPOSITIONS FOR IDS GENE TRANSFER AND METHODS OF USE THEREOF
    Publication number: 20210361778
    Abstract: Provided are adeno-associated virus (AAV) compositions that can restore IDS gene function in cells, and methods for using the these AAV compositions to treat disorders associated with reduction of IDS gene function (e.g., Hunter syndrome). Also provided are compositions, systems and methods for making the AAV compositions.
    Type: Application
    Filed: April 5, 2021
    Publication date: November 25, 2021
    Inventors: Jacinthe GINGRAS, Kruti PATEL, Laura Jane SMITH, Yvonne WHITE, Serena Nicole DOLLIVE, Laura VAN LIESHOUT, Brenda BURNHAM
  • ADENO-ASSOCIATED VIRUS COMPOSITIONS FOR RESTORING PAH GENE FUNCTION AND METHODS OF USE THEREOF
    Publication number: 20210130794
    Abstract: Provided herein are adeno-associated virus (AAV) compositions that can restore phenylalanine hydroxylase (PAH) gene function in cell. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
    Type: Application
    Filed: October 19, 2020
    Publication date: May 6, 2021
    Inventors: Albert Barnes Seymour, Seemin Seher Ahmed, Jason Boke Wright, Serena Nicole Dollive, James Anthony McSwiggen, Jaime Michelle Prout, Danielle Lauren Sookiasian
  • ADENO-ASSOCIATED VIRUS COMPOSITIONS FOR PAH GENE TRANSFER AND METHODS OF USE THEREOF
    Publication number: 20200316223
    Abstract: Provided herein are adeno-associated virus (AAV) compositions that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell, thereby restoring the PAH gene function. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
    Type: Application
    Filed: March 19, 2020
    Publication date: October 8, 2020
    Inventors: Albert Barnes Seymour, Seemin Seher Ahmed, Jason Boke Wright, Serena Nicole Dollive, Hillard Rubin
  • ADENO-ASSOCIATED VIRUS COMPOSITIONS FOR PAH GENE TRANSFER AND METHODS OF USE THEREOF
    Publication number: 20200289674
    Abstract: Provided herein are adeno-associated virus (AAV) compositions that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell, thereby restoring the PAH gene function. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
    Type: Application
    Filed: February 24, 2020
    Publication date: September 17, 2020
    Inventors: Albert Barnes Seymour, Seemin Seher Ahmed, Jason Boke Wright, Serena Nicole Dollive, Hillard Rubin
  • Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
    Patent number: 10610606
    Abstract: Provided herein are adeno-associated virus (AAV) compositions that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell, thereby restoring the PAH gene function. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: April 7, 2020
    Assignee: HOMOLOGY MEDICINES, INC.
    Inventors: Albert Barnes Seymour, Seemin Seher Ahmed, Jason Boke Wright, Serena Nicole Dollive, Hillard Rubin
  • ADENO-ASSOCIATED VIRUS COMPOSITIONS FOR RESTORING PAH GENE FUNCTION AND METHODS OF USE THEREOF
    Publication number: 20190256867
    Abstract: Provided herein are adeno-associated virus (AAV) compositions that can restore phenylalanine hydroxylase (PAH) gene function in cell. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
    Type: Application
    Filed: February 1, 2019
    Publication date: August 22, 2019
    Inventors: Albert Barnes Seymour, Seemin Seher Ahmed, Jason Boke Wright, Serena Nicole Dollive, James Anthony McSwiggen, Jaime Michelle Prout, Danielle Lauren Sookiasian
  • ADENO-ASSOCIATED VIRUS COMPOSITIONS FOR PAH GENE TRANSFER AND METHODS OF USE THEREOF
    Publication number: 20190231901
    Abstract: Provided herein are adeno-associated virus (AAV) compositions that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell, thereby restoring the PAH gene function. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
    Type: Application
    Filed: March 29, 2019
    Publication date: August 1, 2019
    Inventors: Albert Barnes Seymour, Seemin Seher Ahmed, Jason Boke Wright, Serena Nicole Dollive, Hillard Rubin
  • ADENO-ASSOCIATED VIRUS COMPOSITIONS FOR RESTORING HBB GENE FUNCTION AND METHODS OF USE THEREOF
    Publication number: 20190134118
    Abstract: Provided herein are adeno-associated virus (AAV) compositions for correcting a mutation in a beta globin gene (HBB) gene and methods of using the same to correct an HBB gene mutation in a cell. Also provided are packaging systems for making the adeno-associated virus compositions.
    Type: Application
    Filed: October 17, 2018
    Publication date: May 9, 2019
    Inventors: Saswati Chatterjee, Kamehameha K. Wong, Jr., Marwa BenHajSalah, Laura Jane Smith, Albert Barnes Seymour, Jason Boke Wright, James Anthony McSwiggen, Serena Nicole Dollive, Thia Baboval St. Martin, Jaime Michelle Prout