Patents by Inventor Serge Auvin

Serge Auvin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazolidine-2,4-dione dervatives
    Patent number: 9975880
    Abstract: Imidazolidine-2,4-dione derivatives of formula (I): These compounds have anti-proliferative activity and are useful for treating pathological states and diseases linked to an abnormal cell proliferation, such as cancer.
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: May 22, 2018
    Assignee: IPSEN PHARMA S.A.S.
    Inventors: Serge Auvin, Christophe Lanco, Oliver Dutruel, Qi Chao, Kaichun Gu
  • Substituted biphenyl analogues as dual inhibitors of aromatase and sulfatase
    Patent number: 9682941
    Abstract: The present invention relates to new biphenyl derivatives of formula These compounds acting as aromatase and sulfatase inhibitors, they are particularly useful for treating pathological conditions or diseases in which aromatase and sulfatase are involved. Moreover, the present invention provides processes for the preparation of these compounds. The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament, in particular for the treatment of diseases characterized by aromatase and sulfatase activity such as hormone-dependent cancers.
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: June 20, 2017
    Assignee: ESTRYX PHARMA LIMITED
    Inventors: Serge Auvin, Olivier Lavergne, Qi Chao, Yufeng Chen
  • Imidazolidine-2,4-dione derivatives
    Patent number: 9676752
    Abstract: Imidazolidine-2,4-dione derivatives of formula (I): The compounds have anti-proliferative activity and are useful for treating pathological states and diseases linked to an abnormal cell proliferation such as cancer.
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: June 13, 2017
    Assignee: IPSEN PHARMA S.A.S.
    Inventors: Serge Auvin, Christophe Lanco, Qi Chao, Kaichun Gu
  • NEW SUBSTITUTED BIPHENYL ANALOGUES AS DUAL INHIBITORS OF AROMATASE AND SULFATASE
    Publication number: 20170001964
    Abstract: The present invention relates to new biphenyl derivatives of formula These compounds acting as aromatase and sulfatase inhibitors, they are particularly useful for treating pathological conditions or diseases in which aromatase and sulfatase are involved. Moreover, the present invention provides processes for the preparation of these compounds. The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament, in particular for the treatment of diseases characterized by aromatase and sulfatase activity such as hormone-dependent cancers.
    Type: Application
    Filed: December 31, 2013
    Publication date: January 5, 2017
    Inventors: Serge AUVIN, Olivier LAVERGNE, Qi CHAO, Yufeng CHEN
  • NOVEL IMIDAZOLIDINE-2,4-DIONE DERIVATIVES
    Publication number: 20160318908
    Abstract: Imidazolidine-2,4-dione derivatives of formula (I): These compounds have anti-proliferative activity and are useful for treating pathological states and diseases linked to an abnormal cell proliferation, such as cancer.
    Type: Application
    Filed: December 31, 2013
    Publication date: November 3, 2016
    Inventors: Serge AUVIN, Christophe LANCO, Oliver DUTRUEL, Qi CHAO, Kaichun GU
  • NOVEL IMIDAZOLIDINE-2,4-DIONE DERIVATIVES
    Publication number: 20160318902
    Abstract: Imidazolidine-2,4-dione derivatives of formula (I): The compounds have anti-proliferative activity and are useful for treating pathological states and diseases linked to an abnormal cell proliferation such as cancer.
    Type: Application
    Filed: December 31, 2013
    Publication date: November 3, 2016
    Inventors: Serge AUVIN, Christophe LANCO, Qi CHAO, Kaichun GU
  • Imidazolidine-2,4-dione derivatives, and use thereof as a cancer drug
    Patent number: 8710091
    Abstract: The present application relates to novel imidazolidine-2,4-dione derivatives of the general formula (I), where R1, R2, R3, R4, X, and Y are variables. Said materials have an antiproliferative activity. They are particularly useful for treating pathological conditions and diseases, such as cancer, that are linked to abnormal cell proliferation. The invention also relates to pharmaceutical compositions containing said materials and to the use thereof for preparing a drug.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: April 29, 2014
    Assignee: Ipsen Pharma S.A.S.
    Inventors: Grégorie Prevost, Serge Auvin, Christophe Lanco, Anne-Marie Liberatore, Olivier Lavergne
  • Composition containing amidine derivatives or carboxamide derivatives and steroids, as a medicament
    Patent number: 8642591
    Abstract: The present invention relates to a composition containing at least one amidine derivative or carboxamide derivative of general formula (I) or (A) in combination with at least one compound chosen from steroids, corticoids or corticosteroids, wherein said composition is suitable for the preparation of a medicament.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: February 4, 2014
    Assignee: Ipsen Pharma S.A.S.
    Inventors: Bernadette Pignol, Serge Auvin, Dennis Bigg, Pierre-Etienne Chabrier de Lassauniere
  • Imidazolidine-2,4-dione derivatives and use thereof as a medicament
    Patent number: 8624037
    Abstract: The subject matter of the present application is novel imidazolidine-2,4-dione derivatives. These products have an antiproliferative activity. They are particularly advantageous for treating pathological conditions and diseases associated with abnormal cell proliferation, such as cancers. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for preparing a medicament.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: January 7, 2014
    Assignee: Ipsen Pharma S.A.S.
    Inventors: Dennis Bigg, Serge Auvin, Christophe Lanco, Grégoire Prevost
  • IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND USE THEREOF AS A MEDICAMENT
    Publication number: 20120095068
    Abstract: The subject matter of the present application is novel imidazolidine-2,4-dione derivatives of general formula (I) in which R1, R2, R3 and X are variables. These products have an anti-proliferative activity. They are particularly advantageous for treating pathological conditions and diseases associated with abnormal cell proliferation, such as cancers. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for preparing a medicament.
    Type: Application
    Filed: April 16, 2010
    Publication date: April 19, 2012
    Applicant: Ipsen Pharma S.A.S.
    Inventors: Dennis Bigg, Serge Auvin, Christophe Lanco, Grégoire Prevost
  • IMIDAZOLIDINE-2,4-DIONE DERIVATIVES, AND USE THEREOF AS A CANCER DRUG
    Publication number: 20120083514
    Abstract: The present application relates to novel imidazolidine-2,4-dione derivatives of the general formula (I), where R1, R2, R3, R4, X, and Y are variables. Said materials have an antiproliferative activity. They are particularly useful for treating pathological conditions and diseases, such as cancer, that are linked to abnormal cell proliferation. The invention also relates to pharmaceutical compositions containing said materials and to the use thereof for preparing a drug.
    Type: Application
    Filed: April 16, 2010
    Publication date: April 5, 2012
    Applicant: Ipsen Pharma S.A.S.
    Inventors: Gregoire Prevost, Serge Auvin, Christophe Lanco, Anne-Marie Liberatore, Olivier Lavergne
  • Use of a phenothiazine derivative for preventing and/or treating hearing loss
    Patent number: 7696197
    Abstract: The invention concerns the use of a phenothiazine derivative of formula (I), wherein: R represents the hydrogen atom, an alkyl radical, arylalkyl, or —C(O)R?, for preparing a medicine for preventing and/or treating hearing loss.
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: April 13, 2010
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques
    Inventors: Bernadette Pignol, Jean-Luc Puel, Serge Auvin, Pierre-Entienne Chabrier de Lassauniere, Jing Wang
  • Amidine derivatives and their applications as a medicament
    Patent number: 7659266
    Abstract: The invention concerns amidine derivatives of general formula (I) exhibiting an inhibitory activity of calpains and/or a trapping activity of reactive forms of oxygen.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: February 9, 2010
    Assignee: S.C.R.A.S.
    Inventors: Serge Auvin, Dennis Bigg, Pierre-Etienne Chabrier De Lassauniere, Bernadette Pignol
  • Derivatives of amidines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
    Patent number: 7576241
    Abstract: A compound of the formula wherein the substituents are defined as in the specification useful as intermediates.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: August 18, 2009
    Assignee: Ipsen Pharma S.A.S.
    Inventors: Serge Auvin, Pierre-Etienne Chabrier de Lassauniere, Jeremiah Harnett, Dominique Pons, Gerard Ulibarri
  • Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
    Patent number: 7553976
    Abstract: The invention relates to new derivatives of 2-(iminomethyl)amino-phenyl which are NO synthase inhibitors and can trap reactive oxygen species. These compounds can notably be used for the treatment of stroke, of neurodegenerative diseases and of ischemic or hemorragic cardiac of cerebral infarctions.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: June 30, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications (S.C.R.A.S.)
    Inventors: Pierre Etienne Chabrier De Lassauniere, Serge Auvin, Dennis Bigg, Michel Auquet, Jeremiah Harnett
  • COMPOSITION CONTAINING AMIDINE DERIVATIVES OR CARBOXAMIDE DERIVATIVES AND STEROIDS, AS A MEDICAMENT
    Publication number: 20090149430
    Abstract: The present invention relates to a composition containing at least one amidine derivative or carboxamide derivative of general formula (I) or (A) in combination with at least one compound chosen from steroids, corticoids or corticosteroids, wherein said composition is suitable for the preparation of a medicament.
    Type: Application
    Filed: March 6, 2007
    Publication date: June 11, 2009
    Inventors: Bernadette Pignol, Serge Auvin, Dennis Bigg, Pierre-Etienne Chabrier De Lassauniere
  • AMIDINE DERIVATIVES AND THEIR APPLICATIONS AS A MEDICAMENT
    Publication number: 20090018120
    Abstract: The invention concerns amidine derivatives of general formula (I) exhibiting an inhibitory activity of calpains and/or a trapping activity of reactive forms of oxygen.
    Type: Application
    Filed: October 18, 2006
    Publication date: January 15, 2009
    Applicant: Societe de Conseils de Recherches et D'Applications Scientifiques
    Inventors: Serge Auvin, Dennis Bigg, Pierre-Etienne Chabrier De Lassauniere, Bernadette Pignol
  • Derivatives of amidines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
    Patent number: 7473779
    Abstract: Novel derivatives of amidines of formula wherein the substituents are defined as in the specification which are useful for inhibiting activity on NO-synthase enzymes producing nitrogen mono oxide and/or trapping the reactive oxygen species (ROS) making them useful for treating various diseases.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: January 6, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Serge Auvin, Pierre-Etienne Chabrier de Lassauniere, Jeremiah Harnett, Dominique Pons, Gérard Ulibarri
  • 2-hydroxytetrahydrofuran derivatives and use thereof as medicaments
    Patent number: 7465721
    Abstract: A hydroxytetrahydrofuran of formula wherein A is with the substituents as defined in the specification, having a calpain inhibiting activity and/or an activity which traps the reactive oxygen species useful for treating inflammatory and immunological diseases, cardio-vascular and cerebro-vascular diseases, disorders of the central or peripheral nervous system, osteoporosis, muscular dystrophy, proliferative diseases, cataract, rejection reactions following organ transplants and autoimmune and viral diseases.
    Type: Grant
    Filed: December 8, 2004
    Date of Patent: December 16, 2008
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Serge Auvin, Pierre-Etienne Chabrier de Lassauniere
  • Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
    Patent number: 7459558
    Abstract: A method of treating in a warm-blooded animal comprising administering to a warm-blooded animal in need thereof an amount of a compound of the formula wherein the substituents are defined in accordance with the disclosure.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: December 2, 2008
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Dennis Bigg, Michel Auquet, Jeremiah Harnett