Patents by Inventor Serge Christmann-Franck

Serge Christmann-Franck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocyclic pyridazinone derivatives
    Patent number: 10064861
    Abstract: A compound of formula (I) is provided: wherein R1, R2, R3, R4, L and Z have the meaning given in the claims. Further provided is the prophylaxis and treatment of diseases with the compound of formula (I).
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: September 4, 2018
    Assignee: Merck Patent GmbH
    Inventors: Catherine Jorand-Lebrun, Santosh Kulkarni, Serge Christmann-Franck
  • MACROCYCLIC PYRIDAZINONE DERIVATIVES
    Publication number: 20170143713
    Abstract: A compound of formula (I) is provided: wherein R1, R2, R3, R4, L and Z have the meaning given in the claims. Further provided is the prophylaxis and treatment of diseases with the compound of formula (I).
    Type: Application
    Filed: November 30, 2016
    Publication date: May 25, 2017
    Applicant: Merck Patent GmbH
    Inventors: Catherine JORAND-LEBRUN, Santosh KULKARNI, Serge CHRISTMANN-FRANCK
  • Macrocyclic pyridazinone derivatives
    Patent number: 9550794
    Abstract: The present invention relates to compounds of formula (I) Wherein R1, R2, R3, R4, L and Z have the meaning given in claim 1, and their use in the prophylaxis and treatment of diseases.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: January 24, 2017
    Assignee: MERCK PATENT GmbH
    Inventors: Catherine Jorand-Lebrun, Santosh Kulkarni, Serge Christmann-Franck
  • MACROCYCLIC PYRIDAZINONE DERIVATIVES
    Publication number: 20150376206
    Abstract: The present invention relates to compounds of formula (I) Wherein R1, R2, R3, R4, L and Z have the meaning given in claim 1, and their use in the prophylaxis and treatment of diseases.
    Type: Application
    Filed: February 7, 2014
    Publication date: December 31, 2015
    Applicant: Merck Patent GmbH
    Inventors: Catherine JORAND-LEBRUN, Santosh KULKARNI, Serge CHRISTMANN-FRANCK
  • Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators
    Patent number: 8575161
    Abstract: The present invention relates to compounds of formula (I) wherein the substituents are as defined in the claims, including pharmaceutical compositions thereof and for their use in the treatment and/or prevention and/or amelioration of one or more symptoms of disease or disorders related to the activity of FXR. The invention is also directed to intermediates and to a method of preparation of compounds of formula (I).
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: November 5, 2013
    Assignee: Merck Patent GmbH
    Inventors: Didier Roche, Gisèle Mautino, Ingo Kober, Francis Contard, Serge Christmann-Franck, Saumitra Sengupta, Ramesh Sistla, Gummadi Venkateshwar Rao
  • Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
    Patent number: 8486964
    Abstract: The present invention relates to fused pyrrolidino-cyclopropane derivatives according to formulae (I) to (IV) as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11-?-HSD-1) and the use of such compounds for the treatment and/or prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: July 16, 2013
    Assignee: Merck Patent GmbH
    Inventors: Eric Valeur, Franck Lepifre, Didier Roche, Denis Carniato, Serge Christmann-Franck, Fabien Schmidlin
  • Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
    Publication number: 20110172265
    Abstract: The present invention relates to fused pyrrolidino-cyclopropane derivatives according to formulae (I) to (IV) as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11-?-HSD-1) and the use of such compounds for the treatment and/or prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
    Type: Application
    Filed: August 5, 2009
    Publication date: July 14, 2011
    Applicant: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Eric Valeur, Franck Lepifre, Didier Roche, Denis Carniato, Serge Christmann-Franck, Febien Schmidlin
  • BENZOFURANE, BENZOTHIOPHENE, BENZOTHIAZOL DERIVATIVES AS FXR MODULATORS
    Publication number: 20110105475
    Abstract: The present invention relates to compounds of formula (I) wherein the substituents are as defined in the claims, including pharmaceutical compositions thereof and for their use in the treatment and/or prevention and/or amelioration of one or more symptoms of disease or disorders related to the activity of FXR. The invention is also directed to intermediates and to a method of preparation of compounds of formula (I).
    Type: Application
    Filed: March 30, 2009
    Publication date: May 5, 2011
    Applicant: MERXCK PATENT GESELLSCHAFT
    Inventors: Didier Roche, Giséle Mautino, Ingo Kober, Francis Contard, Serge Christmann-Franck, Saumitra Sengupta, Ramesh Sistla, Gummadi Venkateshwar Rao