Patents by Inventor Serge Della-Negra

Serge Della-Negra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ion source device
    Patent number: 11004649
    Abstract: The invention provides an electron-impact ion source device having high brightness as compared to known Nier-type ion sources, while providing similar advantages in terms of flexibility of the generated ion species, for example. The ionization chamber of the device operates at high pressures and provides for a large number of interactions between the electron beam and the gas molecules.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: May 11, 2021
    Assignee: LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)
    Inventors: Olivier De Castro, Serge Della-Negra, David Dowsett, Tom Wirtz
  • ION SOURCE DEVICE
    Publication number: 20200066476
    Abstract: The invention provides an electron-impact ion source device having high brightness as compared to known Nier-type ion sources, while providing similar advantages in terms of flexibility of the generated ion species, for example. The ionization chamber of the device operates at high pressures and provides for a large number of interactions between the electron beam and the gas molecules.
    Type: Application
    Filed: February 28, 2018
    Publication date: February 27, 2020
    Inventors: Olivier De Castro, Serge Della-Negra, David Dowsett, Tom Wirtz
  • GOLD IMPLANTATION/DEPOSITION OF BIOLOGICAL SAMPLES FOR LASER DESORPTION TWO AND THREE DIMENSIONAL DEPTH PROFILING OF BIOLOGICAL TISSUES
    Publication number: 20100090101
    Abstract: The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.
    Type: Application
    Filed: December 4, 2009
    Publication date: April 15, 2010
    Applicant: Ionwerks, Inc.
    Inventors: J. Albert Schultz, Michael V. Ugarov, Thomas F. Egan, Agnes Tempez, Yvon Le Bayec, Serge Della-Negra
  • Gold implantation/deposition of biological samples for laser desorption three dimensional depth profiling of tissues
    Patent number: 6989528
    Abstract: The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.
    Type: Grant
    Filed: June 4, 2004
    Date of Patent: January 24, 2006
    Assignee: Ionwerks, Inc.
    Inventors: J. Albert Schultz, Michael V. Ugarov, Thomas F. Egan, Agnes Tempez, Yvon Le Beyec, Serge Della-Negra
  • Gold implantation/deposition of biological samples for laser desorption three dimensional depth profiling of tissues
    Publication number: 20050035284
    Abstract: The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.
    Type: Application
    Filed: June 4, 2004
    Publication date: February 17, 2005
    Inventors: J. Schultz, Michael Ugarov, Thomas Egan, Agnes Tempez, Yvon Le Bayec, Serge Della-Negra