Abstract: An imaging system operable to generate an output image of a contrast agent injected in an imaged subject. The system includes a energy source, a detector, and a display. The detector generates a plurality of radiological images of the imaged subject. The system also includes a computer having a memory in communication with a processor. The memory includes programmable instructions, including acquiring an image of the contrast agent in the imaged subject with a spectra of energy from the energy source; detecting grayscale values of pixel data of the contrast agent in the image; calculating a predicted thickness of the contrast agent relative to the plurality of grayscale values of pixel data of the contrast agent detected in the image; and generating an output image comprising an illustration of the predicted thickness of the contrast agent for illustration on the display.