Abstract: The invention relates to a compound of formula (I) and to the pharmaceutically acceptable salts thereof. The invention also relates to the use of said compound of formula (I) in the treatment of cancer, particularly by photodynamic therapy.

Abstract: The invention relates to a compound of formula (I) and to the pharmaceutically acceptable salts thereof. The invention also relates to the use of said compound of formula (I) in the treatment of cancer, particularly by photodynamic therapy.

Abstract: System (1) for treatment by photodynamic therapy comprising an illuminating member (6) which comprises: —a core (35) carrying a light emitting surface (37), and —a hollow sheath (10) adapted to receive the core (35) with the light emitting surface (37) arranged within a balloon (11), the balloon (11) comprising a wall (12) which has an inner surface delimiting an internal space, and an outer surface, the wall (12) being flexible, wherein the internal space of the balloon (11) has a variable capacity, the wall (12) of the balloon (11) being elastically extendible and the balloon (11) presenting a plurality of inflated states in each of which the internal space is filled with a volume of light diffusing solution, and wherein the system further comprises a support provided with a transfer function relating the volume of light diffusing solution of each inflated state with at least one of a corresponding distribution of light power at the outer surface of the wall (12) of the balloon (11) and a corresponding time

Abstract: System (1) for treatment by photodynamic therapy comprising an illuminating member (6) which comprises: —a core (35) carrying a light emitting surface (37), and —a hollow sheath (10) adapted to receive the core (35) with the light emitting surface (37) arranged within a balloon (11), the balloon (11) comprising a wall (12) which has an inner surface delimiting an internal space, and an outer surface, the wall (12) being flexible, wherein the internal space of the balloon (11) has a variable capacity, the wall (12) of the balloon (11) being elastically extendible and the balloon (11) presenting a plurality of inflated states in each of which the internal space is filled with a volume of light diffusing solution, and wherein the system further comprises a support provided with a transfer function relating the volume of light diffusing solution of each inflated state with at least one of a corresponding distribution of light power at the outer surface of the wall (12) of the balloon (11) and a corresponding time

Abstract: The system comprises: —a bundle of light fibers (11) connected to a light-emitting source (8), and both transmitting light inside the light fiber and emitting light toward a treatment volume (V), —a temperature-modifying system attached to the bundle of light fibers (11) to modify temperature in the treatment volume (V).

Abstract: An optical fiber mode scrambler adapted to give a determined bending to an optical fiber inserted in the mode scrambler, the mode scrambler having a general extension direction X, the mode scrambler having a morphology adapted to give the optical fiber a direction along X at the entry of the scrambler, and then to bend the fiber to bring the fiber substantially in the X, Y plan in the ?X and Y directions, before bringing the fiber in a rotation around the X axis substantially in the Y, Z plan in the anti clockwise direction for one full rotation, and then bending the fiber to bring the fiber substantially in the X, Y plan in the ?X and ?Y directions, and then bending the fiber to give the optical fiber a direction along X at the exit of the scrambler.

Abstract: An optical fiber mode scrambler adapted to give a determined bending to an optical fiber inserted in the mode scrambler, the mode scrambler having a general extension direction X, the mode scrambler having a morphology adapted to give the optical fiber a direction along X at the entry of the scrambler, and then to bend the fiber to bring the fiber substantially in the X, Y plan in the ?X and Y directions, before bringing the fiber in a rotation around the X axis substantially in the Y, Z plan in the anti clockwise direction for one full rotation, and then bending the fiber to bring the fiber substantially in the X, Y plan in the ?X and ?Y directions, and then bending the fiber to give the optical fiber a direction along X at the exit of the scrambler.

Abstract: Described are methods of reshaping a cartilage structure. One such method comprises creating a virtual three dimensional image of the cartilage structure; manipulating the virtual three dimensional image of the cartilage structure so as to obtain a virtual three dimensional image of a desired final shape of the cartilage structure; creating a virtual prototype of a device to hold the cartilage structure in the desired final shape of the cartilage structure; manufacturing the device; lasing the cartilage structure; and fitting the manufactured device to the cartilage structure (e.g., ear).

Abstract: System for treatment by photodynamic therapy comprising: —an illuminating device (10) including a light emitting surface for illuminating an internal surface to be treated with a light adapted to activate a photosensitizer compound, the light emitting surface emitting light with a distribution of light power comprising fractions of light power decreasing from a maximum at the light emitting surface, the light emitting surface having a determined illumination profile that provides respective illuminated areas for a plurality of the fractions of light power, —a positioning system (40) adapted to position in real-time the light emitting surface within a reference frame, —an electronic unit (45) connected to the positioning system (40) and adapted to monitor in real-time a dose of light energy delivered to the internal surface based on the illumination profile and the position of the light emitting surface.

Abstract: Described are methods of reshaping a cartilage structure. One such method comprises creating a virtual three dimensional image of the cartilage structure; manipulating the virtual three dimensional image of the cartilage structure so as to obtain a virtual three dimensional image of a desired final shape of the cartilage structure; creating a virtual prototype of a device to hold the cartilage structure in the desired final shape of the cartilage structure; manufacturing the device; lasing the cartilage structure; and fitting the manufactured device to the cartilage structure (e.g., ear).

Abstract: Described are methods of reshaping a cartilage structure. One such method comprises creating a virtual three dimensional image of the cartilage structure; manipulating the virtual three dimensional image of the cartilage structure so as to obtain a virtual three dimensional image of a desired final shape of the cartilage structure; creating a virtual prototype of a device to hold the cartilage structure in the desired final shape of the cartilage structure; manufacturing the device; lasing the cartilage structure; and fitting the manufactured device to the cartilage structure (e.g., ear).

Abstract: The system comprises: —a bundle of light fibers (11) connected to a light-emitting source (8), and both transmitting light inside the light fiber and emitting light toward a treatment volume (V), —a temperature-modifying system attached to the bundle of light fibers (11) to modify temperature in the treatment volume (V).

Abstract: A medical device (1) comprising a flexible light source wherein said flexible light source comprises two or more individually manageable areas (2, 3, 4) of light emission and wherein each area (2, 3, 4) comprises a light diffuser textile comprising optical fibres (10) providing side diffusion of a light, method for its manufacture and medical uses.

Abstract: Prostate phantom comprising an artificial prostate (1) and an artificial lesion arranged within the artificial prostate (1), wherein the artificial prostate (1) comprises: a first part (1a) mimicking a peripheral zone of a zonal anatomy of the prostate, the first part (1a) being made of a first artificial tissue and comprising a closed outer surface, at least a second part (1b) separate from the first part (1a) and mimicking at least a second zone of the zonal anatomy of the prostate, the second part (1b) being made of a second artificial tissue and comprising a closed outer surface, the first (1a) and second (1b) parts contacting each other along an interface mimicking a boundary between the peripheral zone and the second zone.

Abstract: Prostate phantom comprising an artificial prostate (1) and an artificial lesion arranged within the artificial prostate (1), wherein the artificial prostate (1) comprises: a first part (1a) mimicking a peripheral zone of a zonal anatomy of the prostate, the first part (1a) being made of a first artificial tissue and comprising a closed outer surface, at least a second part (1b) separate from the first part (1a) and mimicking at least a second zone of the zonal anatomy of the prostate, the second part (1b) being made of a second artificial tissue and comprising a closed outer surface, the first (1a) and second (1b) parts contacting each other along an interface mimicking a boundary between the peripheral zone and the second zone.

Abstract: Described are methods of reshaping a cartilage structure. One such method comprises creating a virtual three dimensional image of the cartilage structure; manipulating the virtual three dimensional image of the cartilage structure so as to obtain a virtual three dimensional image of a desired final shape of the cartilage structure; creating a virtual prototype of a device to hold the cartilage structure in the desired final shape of the cartilage structure; manufacturing the device; lasing the cartilage structure; and fitting the manufactured device to the cartilage structure (e.g., ear).

Abstract: Described are methods of reshaping a cartilage structure. One such method comprises creating a virtual three dimensional image of the cartilage structure; manipulating the virtual three dimensional image of the cartilage structure so as to obtain a virtual three dimensional image of a desired final shape of the cartilage structure; creating a virtual prototype of a device to hold the cartilage structure in the desired final shape of the cartilage structure; manufacturing the device; lasing the cartilage structure; and fitting the manufactured device to the cartilage structure (e.g., ear).

Abstract: A networked system in which the majority of data bypass the server (101) to improve end-to-end performance of network access by achieving higher throughput between the network (130) and storage system (110). The apparatus consists of a network interface (120), server computer interface (240), and storage interface (250); and a switching element (201) and a high-layer protocol decoding and control unit (205). Incoming traffic is decoded and compared against a routing table. If there is a matching entry, it will be routed to the storage interface or sent to the server for further processing by default. The routing table entries are set up based on the initial nature of the applications. Subsequently, barring any changes or errors, there will be no data exchange between the server and the device. There may also be a speed matching funcion between the network and storage, load balancing function for servers, and flow control for priority and QOS purposes.

Abstract: Device for treatment of a part of a human or animal body, including: treatment dose delivery means enabling treatment doses to be delivered to the human or animal body, mapping means enabling a zone or a volume of the body to be treated to be mapped and spatially defined in a predefined frame of reference and in a form of mapping data, localisation means enabling the instantaneous position of the treatment dose delivery means outlet to be localised in the form of localisation data in the frame of reference, electronic control means, which, are suitable for recording the mapping data of at least one zone or one volume of the body to be treated, acquired with the help of the mapping means, and which, enable a treatment to be controlled by using, during the course of the treatment, at least the mapping data and the localisation data.

Abstract: The invention relates to a method of mapping the intraretinal pH of a retina which is marked by a pH-dependent fluorescent marker, in which the retina is illuminated with a first excitation radiation. According to the invention, a first image of the fluorescence emitted by the retina is formed as a bi-directional matrix of pixels at the wavelength of the peak of the fluorescence emission spectrum. Subsequently, the retina is illuminated with a second excitation radiation and a second image is formed of the fluorescence emitted thereby. Finally, the ratio at each pixel between the levels of fluorescence emitted in response to the two respective wavelengths is calculated, said ratio being representative of the pH of the retina, and a pH map of the retina is deduced.