Patents by Inventor Serge Petrus Donkers

Serge Petrus Donkers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of polypeptides by improved secretion
    Patent number: 7968312
    Abstract: The present invention relates to polypeptides that have an activity corresponding to at least one activity of the SEC61 polypeptide, polynucleotides encoding these polypeptides and the use thereof in the preparation of host cells suitable for production of a polypeptide of interest. Such host cells may have an increased capacity to secrete a polypeptide of interest.
    Type: Grant
    Filed: June 16, 2005
    Date of Patent: June 28, 2011
    Assignee: DSM IP Assets B.V.
    Inventors: Cornelis Maria Jacobus Sagt, Nöel Nicolaas Maria Elisabeth Van Peij, Linda De Lange, Martina Beishuizen, Serge Petrus Donkers
  • Method for producing a compound of interest in a filamentous fungal cell
    Patent number: 7888489
    Abstract: The invention relates to a nucleotide sequence comprising; a synonymous nucleotide coding sequence with optimized codon frequency such that a native codon has been exchanged with a synonymous codon, the synonymous codon encoding the same amino acid as the native codon and having a higher frequency in codon usage as defined in Table 1 than the native codon; and optionally the nucleotide sequence comprises control sequences such as; one translational termination sequence orientated in 5? towards 3? direction selected from the following list of sequences; TAAG, TAGA and TAAA, preferably TAAA, and/or one translational initiator coding sequence orientated in 5? towards 3? direction selected from the following list of sequences; gctnccyyc (SEQ ID NO:20), using ambiguity codes for nucleotides; v (A/C/G); n (A/C/G/T), preferably 5?-GCT TCC TTC-3? (SEQ ID NO:21).
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: February 15, 2011
    Assignee: DSM IP Assets B.V.
    Inventors: Johannes Andries Roubos, Serge Petrus Donkers, Hein Stam, Noël Nicolaas Maria Elisabeth Van Peij
  • Production of Polypeptides by Improved Secretion
    Publication number: 20090004693
    Abstract: The present invention relates to polypeptides that have an activity corresponding to at least one activity of the SEC61 polypeptide, polynucleotides encoding these polypeptides and the use thereof in the preparation of host cells suitable for production of a polypeptide of interest. Such host cells may have an increased capacity to secrete a polypeptide of interest.
    Type: Application
    Filed: June 16, 2005
    Publication date: January 1, 2009
    Inventors: Cornelis Maria Sagt, Noel Nicolaas Maria Elisabeth Peij, Linda De Lange, Martina Beishuizen, Serge Petrus Donkers
  • Method for Producing a Compound of Interest in a Filamentous Fungal Cell
    Publication number: 20080118965
    Abstract: The invention relates to a nucleotide sequence comprising: a synonymous nucleotide coding sequence with optimized codon frequency such that a native codon has been exchanged with a synonymous codon, said synonymous codon encoding the same amino acid as the native codon and having a higher frequency in codon usage as defined in Table 1 than the native codon; and optionally said nucleotide sequence comprises control sequences such as: one translational termination sequence orientated in 5? towards 3? direction selected from the following list of sequences: TAAG, TAGA and TAAA, preferably TAAA, and/or one translational initiator coding sequence orientated in 5? towards 3? direction selected from the following list of sequences: gctnccyyc, using ambiguity codes for nucleotides: v (A/C/G); n (A/C/G/T), preferably 5?-GCT TCC TTC-3?.
    Type: Application
    Filed: January 24, 2006
    Publication date: May 22, 2008
    Inventors: Johannes Andries Roubos, Serge Petrus Donkers, Hein Stam, Noel Nicolaas Maria Elisabeth Van Peij