Patents by Inventor Serge Saxonov

Serge Saxonov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENETIC COMPARISONS BETWEEN GRANDPARENTS AND GRANDCHILDREN
    Publication number: 20180181710
    Abstract: Displaying a comparison of genotypic information between relatives is disclosed, including receiving an indication that a first individual is a grandparent, receiving an indication that a second individual is a grandchild of the first individual, comparing the genotypic information of the first individual and the second individual and calculating a similarity score, and displaying an indication of the similarity score graphically using colors.
    Type: Application
    Filed: December 1, 2017
    Publication date: June 28, 2018
    Inventors: Linda Avey, Oleksiy Khomenko, Brian Thomas Naughton, Serge Saxonov, Anne Wojcicki, Alexander Wong
  • DROPLET-BASED ANALYSIS METHOD
    Publication number: 20180147573
    Abstract: Devices and methods for generating droplets. An exemplary device comprises a substantially planar base portion including a bottom surface having a plurality of microfluidic channels formed therein as recessed regions of the bottom surface. The device also comprises a plurality of protrusions projecting from a top surface of the base portion and each formed integrally with the base portion. The device further comprises a sample well, a carrier well, and a droplet well. Each well has an upper portion created by one of the protrusions. A cover layer is attached to the bottom surface of the base portion and seals a bottom side of each microfluidic channel.
    Type: Application
    Filed: September 18, 2017
    Publication date: May 31, 2018
    Inventors: Amy L. Hiddessen, Donald A. Masquelier, Kevin D. Ness, Benjamin J. Hindson, Anthony J. Makarewicz, Jr., Erin R. Chia, Billy W. Colston, Jr., Serge Saxonov, Svilen S. Tzonev, Michael Y. Lucero, Ryan T. Koehler
  • METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES
    Publication number: 20180142292
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
    Type: Application
    Filed: January 16, 2018
    Publication date: May 24, 2018
    Inventors: Benjamin Hindson, Christopher Hindson, Michael Schnall-Levin, Kevin Ness, Mirna Jarosz, Serge Saxonov, Paul Hardenbol, Rajiv Bharadwaj, Grace Zheng, Philip Belgrader
  • CAPSULE ARRAY DEVICES AND METHODS OF USE
    Publication number: 20180112253
    Abstract: This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis.
    Type: Application
    Filed: December 19, 2017
    Publication date: April 26, 2018
    Inventors: Benjamin Hindson, Serge Saxonov, Michael Schnall-Levin
  • METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES
    Publication number: 20180112266
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
    Type: Application
    Filed: December 19, 2017
    Publication date: April 26, 2018
    Inventors: Benjamin Hindson, Christopher Hindson, Michael Schnall-Levin, Kevin Ness, Mirna Jarosz, Serge Saxonov, Paul Hardenbol, Rajiv Bharadwaj, Grace Zheng, Phillip Belgrader
  • Methods and systems for processing polynucleotides
    Patent number: 9951386
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: April 24, 2018
    Assignee: 10X GENOMICS, INC.
    Inventors: Benjamin Hindson, Christopher Hindson, Michael Schnall-Levin, Kevin Ness, Mirna Jarosz, Serge Saxonov
  • METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES
    Publication number: 20180094313
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
    Type: Application
    Filed: December 5, 2017
    Publication date: April 5, 2018
    Inventors: Benjamin Hindson, Christopher Hindson, Micheal Schnall-Levin, Kevin Ness, Mirna Jarosz, Serge Saxonov, Paul Hardenbol, Rajiv Bharadwaj, Xinying Zheng, Phillip Belgrader
  • COMPOSITIONS AND METHODS FOR SAMPLE PROCESSING
    Publication number: 20180094298
    Abstract: This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. Often, the beads provides herein are degradable. For example, they may contain disulfide bonds that are susceptible to reducing agents. The methods provided herein include methods of making libraries of barcoded beads as well as methods of combining the beads with a sample, such as by using a microfluidic device.
    Type: Application
    Filed: September 28, 2017
    Publication date: April 5, 2018
    Inventors: Benjamin Hindson, Christopher Hindson, Michael Schnall-Levin, Kevin Ness, Mirna Jarosz, Donald Masquelier, Serge Saxonov, Landon Merrill, Andrew Price, Paul Hardenbol, Yuan Li
  • METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES
    Publication number: 20180094312
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
    Type: Application
    Filed: December 5, 2017
    Publication date: April 5, 2018
    Inventors: Benjamin Hindson, Christopher Hindson, Michael Schnall-Levin, Kevin Ness, Mirna Jarosz, Serge Saxonov, Paul Hardenbol, Rajiv Bharadwaj, Xinying Zheng, Phillip Belgrader
  • Methods and Systems for Processing Polynucleotides
    Publication number: 20180094315
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
    Type: Application
    Filed: December 5, 2017
    Publication date: April 5, 2018
    Inventors: Benjamin Hindson, Christopher Hindson, Michael Schnall-Levin, Kevin Ness, Mirna Jarosz, Serge Saxonov, Paul Hardenbol, Rajiv Bharadwaj, Xinying Zheng, Phillip Belgrader
  • Methods and Systems for Processing Polynucleotides
    Publication number: 20180094314
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
    Type: Application
    Filed: December 5, 2017
    Publication date: April 5, 2018
    Inventors: Benjamin Hindson, Christopher Hindson, Michael Schnall-Levin, Kevin Ness, Mirna Jarosz, Serge Saxonov, Paul Hardenbol, Rajiv Bharadwaj, Xinying Zheng, Phillip Belgrader
  • Multiplexed digital assays
    Patent number: 9921154
    Abstract: System, including methods and apparatus, for performing a multiplexed digital assay.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: March 20, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Yann Jouvenot, Serge Saxonov, Simant Dube, John Frederick Regan
  • COMPOSITIONS AND METHODS FOR SAMPLE PROCESSING
    Publication number: 20180051321
    Abstract: This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. Often, the beads provides herein are degradable. For example, they may contain disulfide bonds that are susceptible to reducing agents. The methods provided herein include methods of making libraries of barcoded beads as well as methods of combining the beads with a sample, such as by using a microfluidic device.
    Type: Application
    Filed: September 28, 2017
    Publication date: February 22, 2018
    Inventors: Benjamin Hindson, Christopher Hindson, Michael Schnall-Levin, Kevin Ness, Mirna Jarosz, Donald Masquelier, Serge Saxonov, Landon Merrill, Andrew Price, Paul Hardenbol, Yuan Li
  • Methods and compositions for nucleic acid analysis
    Patent number: 9885034
    Abstract: Provided herein are methods, compositions, and kits for assays, many of which involve amplification reactions such as digital PCR or droplet digital PCR. The assays may be used for such applications as sequencing, copy number variation analysis, and others. In some cases, the assays involve subdividing a sample into multiple partitions (e.g., droplets) and merging the partitions with other partitions that comprise adaptors with barcodes.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: February 6, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Serge Saxonov
  • CAPSULE ARRAY DEVICES AND METHODS OF USE
    Publication number: 20180030512
    Abstract: This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis.
    Type: Application
    Filed: September 28, 2017
    Publication date: February 1, 2018
    Inventors: Benjamin Hindson, Serge Saxonov, Michael Schnall-Levin
  • FLUIDIC DEVICES, SYSTEMS, AND METHODS FOR ENCAPSULATING AND PARTITIONING REAGENTS, AND APPLICATIONS OF SAME
    Publication number: 20180015473
    Abstract: The disclosure provides devices, systems and methods for the generation of encapsulated reagents and the partitioning of encapsulated reagents for use in subsequent analyses and/or processing, such as in the field of biological analyses and characterization.
    Type: Application
    Filed: September 27, 2017
    Publication date: January 18, 2018
    Inventors: Rajiv Bharadwaj, Kevin Ness, Debkishore Mitra, Donald Masquelier, Anthony Makarewicz, Christopher Hindson, Benjamin Hindson, Serge Saxonov
  • METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES
    Publication number: 20180016634
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
    Type: Application
    Filed: September 27, 2017
    Publication date: January 18, 2018
    Inventors: Benjamin Hindson, Christopher Hindson, Michael Schnall-Levin, Kevin Ness, Mirna Jarosz, Serge Saxonov, Paul Hardenbol, Rajiv Bharadwaj, Grace Zheng, Phillip Belgrader
  • FLUIDIC DEVICES, SYSTEMS, AND METHODS FOR ENCAPSULATING AND PARTITIONING REAGENTS, AND APPLICATIONS OF SAME
    Publication number: 20180015472
    Abstract: The disclosure provides devices, systems and methods for the generation of encapsulated reagents and the partitioning of encapsulated reagents for use in subsequent analyses and/or processing, such as in the field of biological analyses and characterization.
    Type: Application
    Filed: September 27, 2017
    Publication date: January 18, 2018
    Inventors: Rajiv Bharadwaj, Kevin Ness, Debkishore Mitra, Donald Masquelier, Anthony Makarewicz, Christopher Hindson, Benjamin Hindson, Serge Saxonov
  • FLUIDIC DEVICES, SYSTEMS, AND METHODS FOR ENCAPSULATING AND PARTITIONING REAGENTS, AND APPLICATIONS OF SAME
    Publication number: 20180008984
    Abstract: The disclosure provides devices, systems and methods for the generation of encapsulated reagents and the partitioning of encapsulated reagents for use in subsequent analyses and/or processing, such as in the field of biological analyses and characterization.
    Type: Application
    Filed: August 28, 2017
    Publication date: January 11, 2018
    Inventors: Rajiv Bharadwaj, Kevin Ness, Debkishore Mitra, Donald Masquelier, Anthony Makarewicz, Christopher Hindson, Benjamin Hindson, Serge Saxonov
  • Genetic comparisons between grandparents and grandchildren
    Patent number: 9864835
    Abstract: Displaying a comparison of genotypic information between relatives is disclosed, including receiving an indication that a first individual is a grandparent, receiving an indication that a second individual is a grandchild of the first individual, comparing the genotypic information of the first individual and the second individual and calculating a similarity score, and displaying an indication of the similarity score graphically using colors.
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: January 9, 2018
    Assignee: 23andMe, Inc.
    Inventors: Linda Avey, Oleksiy Khomenko, Brian Thomas Naughton, Serge Saxonov, Anne Wojcicki, Alexander Wong