Patents by Inventor Sergei Gulnik

Sergei Gulnik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR PREVENTING NON-SPECIFIC INTERACTIONS BETWEEN POLYMER DYES-ANTIBODY CONJUGATES
    Publication number: 20240125773
    Abstract: The disclosure relates to compositions comprising a non-fluorescent component of a polymer dye such as a monomeric component of a polymer dye, a photo-bleached polymer dye, and/or a polymer dye comprising a quenching moiety, for reducing non-specific interactions of polymer dye conjugates, for example, in Flow Cytometric Analysis of a biological sample. Methods for using such compositions, and kits comprising such compositions are also provided.
    Type: Application
    Filed: February 4, 2022
    Publication date: April 18, 2024
    Inventors: Frederic MONSONIS, Boi Hoa SAN, Arunkumar EASWARAN, Massimiliano TOMASULO, Sergei GULNIK, Rajesh VENKATESH, Shiva Ranjini SRINIVASAN
  • PHOTOACTIVE MACROMOLECULES AND USES THEREOF
    Publication number: 20240052092
    Abstract: The present invention provides water soluble photoactive macromolecular complexes and methods for detecting an analyte in a sample by using a binding agent conjugated to a water soluble photoactive macromolecule.
    Type: Application
    Filed: October 9, 2023
    Publication date: February 15, 2024
    Inventors: Arunkumar Easwaran, Sergei Gulnik
  • POLYMER DYES AND USES THEREOF
    Publication number: 20230399565
    Abstract: The present disclosure provides fused dihydrophenanthrene (DHP) monomers and fluorescent fused DHP polymers, water-soluble fluorescent polymers and copolymers, water-soluble fluorescent polymer complexes, and their use in methods for detecting an analyte in a sample.
    Type: Application
    Filed: June 9, 2023
    Publication date: December 14, 2023
    Inventors: Massimiliano Tomasulo, Mukesh Mudgal, Arunkumar Easwaran, Sergei Gulnik
  • Photoactive macromolecules and uses thereof
    Patent number: 11834551
    Abstract: The present invention provides water soluble photoactive macromolecular complexes and methods for detecting an analyte in a sample by using a binding agent conjugated to a water soluble photoactive macromolecule.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: December 5, 2023
    Assignee: Beckman Coulter, Inc.
    Inventors: Arunkumar Easwaran, Sergei Gulnik
  • POLYMER DYE MODIFICATION AND APPLICATIONS
    Publication number: 20230192943
    Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.
    Type: Application
    Filed: January 6, 2023
    Publication date: June 22, 2023
    Inventors: Arunkumar Easwaran, Sergei Gulnik, Massimiliano Tomasulo
  • Polymer dye modification and applications
    Patent number: 11584825
    Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: February 21, 2023
    Assignee: Beckman Coulter, Inc.
    Inventors: Arunkumar Easwaran, Sergei Gulnik, Massimiliano Tomasulo
  • Compositions and methods for lysis of red blood cells
    Patent number: 11531034
    Abstract: This disclosure provides methods and kits for lysing red blood cells from whole blood.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: December 20, 2022
    Assignee: Beckman Coulter, Inc.
    Inventors: George C. Brittain, IV, Sergei Gulnik
  • PHOTOACTIVE MACROMOLECULES AND USES THEREOF
    Publication number: 20220213260
    Abstract: The present invention provides water soluble photoactive macromolecular complexes and methods for detecting an analyte in a sample by using a binding agent conjugated to a water soluble photoactive macromolecule.
    Type: Application
    Filed: March 21, 2022
    Publication date: July 7, 2022
    Inventors: Arunkumar Easwaran, Sergei Gulnik
  • Photoactive macromolecules and uses thereof
    Patent number: 11208527
    Abstract: The present invention provides water soluble photoactive macromolecular complexes and methods for detecting an analyte in a sample by using a binding agent conjugated to a water soluble photoactive macromolecule.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: December 28, 2021
    Assignee: Beckman Coulter, Inc.
    Inventors: Arunkumar Easwaran, Sergei Gulnik
  • COMPOSITIONS AND METHODS FOR LYSIS OF RED BLOOD CELLS
    Publication number: 20210140984
    Abstract: This disclosure provides methods and kits for lysing red blood cells from whole blood.
    Type: Application
    Filed: May 7, 2018
    Publication date: May 13, 2021
    Inventors: George C. Brittain, IV, Sergei Gulnik
  • POLYMER DYE MODIFICATION AND APPLICATIONS
    Publication number: 20200190253
    Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.
    Type: Application
    Filed: December 11, 2019
    Publication date: June 18, 2020
    Inventors: Arunkumar Easwaran, Sergei Gulnik, Massimiliano Tomasulo
  • PHOTOACTIVE MACROMOLECULES AND USES THEREOF
    Publication number: 20190144601
    Abstract: The present invention provides water soluble photoactive macromolecular complexes and methods for detecting an analyte in a sample by using a binding agent conjugated to a water soluble photoactive macromolecule.
    Type: Application
    Filed: April 14, 2017
    Publication date: May 16, 2019
    Inventors: Arunkumar Easwaran, Sergei Gulnik
  • SUBCELLULAR LOCALIZATION OF TARGET ANALYTES
    Publication number: 20190079094
    Abstract: The present invention provides methods of determining and quantifying the subcellular localization of an analyte within a sample of cells by using at least two permeabilizing reagents.
    Type: Application
    Filed: March 16, 2017
    Publication date: March 14, 2019
    Inventors: George C. Brittain, Sergei Gulnik
  • Proteasome inhibition assay and methods of use
    Patent number: 10073082
    Abstract: Assays that can measure the effect of proteasome inhibitors on target cells in a biological sample are provided. The assays include evaluation of the effects of proteasome inhibitors on proteasome activity in cells in a biological sample.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: September 11, 2018
    Assignees: Beckman Coulter, Inc., University Health Network
    Inventors: T. Vincent Shankey, Sergei Gulnik, Lidice L. Lopez, David W. Hedley, Sue Chow
  • PROTEASOME INHIBITION ASSAY AND METHODS OF USE
    Publication number: 20160258934
    Abstract: Assays that can measure the effect of proteasome inhibitors on target cells in a biological sample are provided. The assays include evaluation of the effects of proteasome inhibitors on proteasome activity in cells in a biological sample.
    Type: Application
    Filed: October 10, 2014
    Publication date: September 8, 2016
    Inventors: Vincent T. SHANKEY, Sergei GULNIK, Lidice L. LOPEZ, David W. HEDLEY, Sue CHOW
  • METHODS FOR INHIBITING DRUG DEGRADATION
    Publication number: 20150284352
    Abstract: Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.
    Type: Application
    Filed: February 9, 2015
    Publication date: October 8, 2015
    Inventors: Michael EISSENSTAT, Dehui DUAN, Sergei GULNIK, John W. Erickson
  • RESISTANCE-REPELLENT RETROVIRAL PROTEASE INHIBITORS
    Publication number: 20100009935
    Abstract: Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV infections in mammals, are also provided.
    Type: Application
    Filed: July 16, 2009
    Publication date: January 14, 2010
    Applicant: SEQUOIA PHARMACEUTICALS
    Inventors: John W. Erickson, Michael Eissenstat, Abelardo Silva, Sergei Gulnik
  • FITNESS ASSAY AND ASSOCIATED METHODS
    Publication number: 20080085918
    Abstract: The present invention provides an assay for determining the biochemical fitness of a biochemical species in a mutant replicating biological entity relative to its predecessor. The present invention further provides a continuous fluorogenic assay for measuring the anti-HIV protease activity of protease inhibitor. The present invention also provides a method of administering a therapeutic compound that reduces the chances of the emergence of drug resistance in therapy.
    Type: Application
    Filed: October 11, 2007
    Publication date: April 10, 2008
    Applicants: Government of the United States of America, represented by Secretary, Departmemt of Health and, Board of Trustees of the University of Illinois
    Inventors: John ERICKSON, Sergei GULNIK, Hiroaki MITSUYA, Arun GHOSH
  • Protease assay for therapeutic drug monitoring
    Patent number: 7320878
    Abstract: The present invention concerns a further development and use of biological assays to determine the amount or concentration of an active ingredient present in a sample. The enzyme assay of the present invention determines the amount or concentration of protease inhibitors, including retroviral protease inhibitors such as HIV inhibitors.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: January 22, 2008
    Assignees: Tibotec Pharmaceuticals, Ltd., Aaron Diamond Aids Research Center, The Rockefeller University
    Inventors: Sergei Gulnik, Betty Yu, John W Erickson, Martin Markowitz
  • Resistance-repellent retroviral protease inhibitors
    Patent number: 7285566
    Abstract: Resistance-repellent and multidrug resistant retroviral protease inhibitors are provided. Pharmaceutical composition comprising such compounds, and methods of using such compounds to treat HIV infections in mammals, are also provided.
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: October 23, 2007
    Inventors: John W. Erickson, Michael Eissenstat, Abelardo Silva, Sergei Gulnik