Patents by Inventor Sergei Merkulov

Sergei Merkulov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human ?2-glycoprotein I expression
    Patent number: 11661447
    Abstract: Provided herein are compositions, systems, kits, and methods for expressing a peptide of interest, such as Apolipoprotein H (ApoH), also known as ?2-glycoprotein I (?2GPI), at increased levels using a non-ApoH signal peptide (e.g., a signal peptide that permits increased protein export from cells). Also provided herein are compositions, systems, kits, and methods for employing such recombinant ApoH with a non-ApoH signal peptide to detect subject Apolipoprotein H antibodies in a sample from a subject (e.g., to diagnose antiphospholipid syndrome in a subject).
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: May 30, 2023
    Assignee: The Cleveland Clinic Foundation
    Inventors: Keith McCrae, Sergei Merkulov, Ravi K. Alluri
  • IMPROVED PEPTIDE EXPRESSION AND APO-H SPECIFIC SUBJECT ANTIBODY DETECTION
    Publication number: 20200291093
    Abstract: Provided herein are compositions, systems, kits, and methods for expressing a peptide of interest, such as Apolipoprotein H (ApoH), also known as ?2-glycoprotein I (?2GPI), at increased levels using a non-ApoH signal peptide (e.g., a signal peptide that permits increased protein export from cells). Also provided herein are compositions, systems, kits, and methods for employing such recombinant ApoH with a non-ApoH signal peptide to detect subject Apolipoprotein H antibodies in a sample from a subject (e.g., to diagnose antiphospholipid syndrome in a subject).
    Type: Application
    Filed: August 3, 2018
    Publication date: September 17, 2020
    Inventors: Keith McCrae, Sergei Merkulov