Patents by Inventor Sergei Nekhai

Sergei Nekhai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR TREATING OR INHIBITING CYTOMEGALOVIRUS INFECTION USING SMALL MOLECULES TARGETING PROTEIN PHOSPHATASE 1
    Publication number: 20240082235
    Abstract: A method for treating or inhibiting cytomegalovirus infection, including administrating an effective amount of a class of small molecules targeting protein phosphatase 1 (PP1) to a subject in need thereof. A method for inhibiting replication of cytomegalovirus, including contacting cytomegalovirus or cells containing the cytomegalovirus with a class of small molecules targeting protein phosphatase 1 (PP1).
    Type: Application
    Filed: December 15, 2021
    Publication date: March 14, 2024
    Applicant: HOWARD UNIVERSITY
    Inventors: Sergei NEKHAI, Christoph STEININGER
  • Inhibitors of protein phosphatase-1 and uses thereof
    Patent number: 9447047
    Abstract: Inhibitors of protein phosphatase-1 (PP-1) and their use in a method for the treatment or prevention of viral infections caused by HIV or ebola virus are disclosed. Inhibitors of protein phosphatase-1 in effective amounts have been shown to slow down viral replication upon contacting ebola virus or cells containing the ebola virus.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: September 20, 2016
    Assignees: Howard University, The Board of Regents of the University of Texas System
    Inventors: Sergei Nekhai, Alexander Bukreyev
  • Inhibitors of Protein Phosphatase-1 and Uses Thereof
    Publication number: 20160024013
    Abstract: Inhibitors of protein phosphatase-1 (PP-1) and their use in a method for the treatment or prevention of viral infections caused by HIV or ebola virus are disclosed. Inhibitors of protein phosphatase-1 in effective amounts have been shown to slow down viral replication upon contacting ebola virus or cells containing the ebola virus.
    Type: Application
    Filed: March 14, 2013
    Publication date: January 28, 2016
    Inventors: Sergei NEKHAI, Alexander BUKREYEV
  • Iron Chelators as HIV-1 Inhibitors
    Publication number: 20150119429
    Abstract: The present invention relates to chelator compounds for chelating metal ions. In particular, the present invention relates to (thio)semicarbazone compounds and (thio)hydrazone compounds, such as PpYeT and PpYaT, which are chelators for metal ions, including iron ions. Therapeutic use of such compounds and/or their metal ion complexes, includes methods for treating and inhibiting HIV-1 replication, particularly in HIV-1 infected cells.
    Type: Application
    Filed: March 14, 2013
    Publication date: April 30, 2015
    Applicant: Howard University
    Inventors: Sergei Nekhai, Dmytro Borisovych Kovalskyy
  • Inhibitors of protein phosphatase-1 and uses thereof
    Patent number: 8278326
    Abstract: Inhibitors of Protein Phosphatase-1 have been shown to slow replication of HIV-1. Inhibitors of PP 1 and their use for treatment or prevention of HIV-1 infections are disclosed.
    Type: Grant
    Filed: April 15, 2009
    Date of Patent: October 2, 2012
    Assignee: Howard University
    Inventors: Sergei Nekhai, Dmytro Borysovich Kovalskyy
  • Inhibitors Of Protein Phosphatase-1 And Uses Thereof
    Publication number: 20090264463
    Abstract: Inhibitors of Protein Phosphatase-1 have been shown to slow replication of HIV-1. Inhibitors of PP 1 and their use for treatment or prevention of HIV-1 infections are disclosed.
    Type: Application
    Filed: April 15, 2009
    Publication date: October 22, 2009
    Inventors: Sergei Nekhai, Dmytro Borysovich Kovalskyy