Patents by Inventor Sergei V. Zaitsev

Sergei V. Zaitsev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeting recombinant therapeutics to circulating red blood cells
    Patent number: 8333973
    Abstract: Fusion proteins comprising a single chain antigen-binding domain (scFv) of a monoclonal antibody, linked to an anti-thrombotic agent, anti-inflammatory agent, or a pro-drug thereof are provided, where the polypeptide binds to a binding site (antigen) expressed on the surface of a red blood cell at a density greater than 5,000 copies per red blood cell. Pharmaceutical compositions comprising these fusion proteins, and methods of delivering an anti-thrombotic agent to the surface of a red blood cell via delivery of these fusion proteins, and methods of treating or preventing thrombosis, tissue ischemia, acute myocardial infarction (AMI), ischemic stroke, cerebrovascular disease, pulmonary embolism, or ischemic peripheral vascular disease via administration of the fusion proteins or compositions comprising same are also provided.
    Type: Grant
    Filed: December 31, 2008
    Date of Patent: December 18, 2012
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Vladimir R. Muzykantov, Sergei V. Zaitsev, Bi-Sen Ding, Douglas B. Cines
  • TARGETING RECOMBINANT THERAPEUTICS TO CIRCULATING RED BLOOD CELLS
    Publication number: 20100285015
    Abstract: Fusion proteins comprising a single chain antigen-binding domain (scFv) of a monoclonal antibody, linked to an anti-thrombotic agent, anti-inflammatory agent, or a pro-drug thereof are provided, where the polypeptide binds to a binding site (antigen) expressed on the surface of a red blood cell at a density greater than 5,000 copies per red blood cell. Pharmaceutical compositions comprising these fusion proteins, and methods of delivering an anti-thrombotic agent to the surface of a red blood cell via delivery of these fusion proteins, and methods of treating or preventing thrombosis, tissue ischemia, acute myocardial infarction (AMI), ischemic stroke, cerebrovascular disease, pulmonary embolism, or ischemic peripheral vascular disease via administration of the fusion proteins or compositions comprising same are also provided.
    Type: Application
    Filed: December 31, 2008
    Publication date: November 11, 2010
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Vladimir R. Muzykantov, Sergei V. Zaitsev, Bi-Sen Ding, Douglas B. Cines