Abstract: The present disclosure provides novel compounds of the formula (I): wherein R0, R1, R2, R3, R4, R5, and R6 are as defined in the detailed description. Two preferred compounds of formulae (IX) and (X) are disclosed. Also disclosed are uses of the disclosed compounds, for example, in regulating glucose transport and in inhibiting acetyl coenzyme A carboxylase.

Abstract: The present invention provides bistramide analogs useful for treating various types of cancer.

Abstract: The present invention provides a novel bistramide analog useful for treating various types of cancer.

Abstract: The present disclosure provides novel compounds of the formula (I): wherein R0, R1, R2, R3, R4, R5, and R6 are as defined in the detailed description. Two preferred compounds of formulae (IX) and (X) are disclosed.

Abstract: The present invention describes leucascandrolide analogs of the formula (I), intermediates of the formula (III), pharmaceutical compositions containing the same, methods for preventing cell proliferation, and methods for treating cancers and other proliferative diseases.

Abstract: The present invention describes leucascandrolide analogs of the formula (I), intermediates of the formula (III), pharmaceutical compositions containing the same, methods for preventing cell proliferation, and methods for treating cancers and other proliferative diseases.

Abstract: There is disclosed a device for multiparallel synthesis or screening of a chemical library that includes at least one, and preferably more than one, plate with a two-dimensional or three-dimensional array of wells. Openings are provided in the side walls between at least some of the wells, through which the fluid can flow between adjacent wells. At least one inlet for each plate is provided whereby fluids can be introduced into the array of wells in each plate and flow between adjacent wells in each of the plates through the openings in the side walls.

Abstract: A device and method for a multiparallel synthesis and screening using a three-dimensional array comprising a plurality of reaction wells having a means for delivery of a fluid or solid along three directions corresponding to the x, y, and z axes of the array. The invention makes use of a plurality of removable sealing elements each of which is positioned across or spans two sides of a reaction well when in a sealing position. The reaction wells may be made of materials such as polypropylene. The sealing elements may be in the form of cylinders, tubes, rods, or tapered pins. The amount of a reaction product produced in the synthesis can be as much as 5 mg or more.