Abstract: The inventive polypeptide is embodied in the form of a similar fragment of the epidermal growth factor of aminoacid ranging from 21 to 31 and capable of efficiently binding with the receptor of the epidermal growth factor as a vector for the directed supply of anticancer agent to tumour cells. The inventive conjugate of said polypeptide contains doxorubicine and has a selective action on cancer tumours and can substantially reduce the resistance of tumour cells with respect to the anticancer agents, the conjugated parts of said agents being binded with the aid of a chemical bond which is unstable in relation to acid hydrolysis. The inventive pharmaceutical composition comprises an efficient quantity of conjugate and a carrier which is fit for intravenous injection. Said invention can be used for medicine for treating cancer patients.

Abstract: A method an apparatus for providing channel state information in a receiver are described. In the method, direct channel state information may be generated based on a calculated error signal, and indirect channel state information may be generated based on a magnitude of a channel frequency response. A channel state selection control signal is generated based on the calculated error signal and magnitude of the channel frequency response. One of the direct channel state information and indirect channel state information may be output based on a logic state of the channel state selection control signal.

Abstract: A system and method of remotely debugging an orchestration service instance providing a means for establishing a communications connection with a computer, wherein the computer is executing a business process service instance. Stored tracking information regarding the orchestration service instance is read, and the orchestration service instance is remotely debugged by way of the communications connection and according to the stored tracking state information.

Abstract: A programmable resistance memory element comprising alternating layers of programmable resistance material layers and stabilizing layers. The stabilizing layers may include metallic titanium or a titanium alloy. The stabilizing layers may include a telluride, such as titanium telluride.

Abstract: This invention discloses a method of producing, in a solid transparent material (3), a hologram of an object; the method includes the steps of: developing a three-dimensional mathematical model of an electro-magnetic field emanating from the object, the field producing an image of the object; computing a corresponding three-dimensional set of points, light scattered from which reconstructs the field; and focusing a pulsed laser beam into the solid transparent material onto each of the points sequentially, the beam being capable, when focused, of causing optical breakdown in the solid transparent material.

Abstract: The present group of inventions relates to processing of multi-component liquid mixtures (MCLM) employing reforming process, preferably for vacuum distillation of hydrocarbon mixtures and can be applied in petroleum refining and chemical industries. The group of invention comprises the method for processing of multi-component liquid mixtures and the plant for its implementation The claimed method of MCLM separation comprises pressurized feeding of hydrocarbon liquid mixture to an ejector nozzle with its further discharging to a vacuum chamber. The novel feature of the method is creation of additional counterpressure jointly with the ejector providing for concentration of power in the vacuum chamber to form a pressure surge. The claimed plant for MCLM processing comprises a feeding pump, a head delivery main, a discharge main, control instrumentation and an evacuating device comprising a horizontal vacuum chamber.

Abstract: The invention relates to building construction and to the production of building products and can be used for constructing low rise residential, industrial and administrative buildings for different climatic zones. The invention increases the quality of products having a complicated configuration, extends the range thereof and makes it possible to obtain a precise geometrical shape of the products. The inventive general-purpose multicavity cassette mould for producing grouted building keyblocks comprises a frame provided with a tray (1) on which lodgements (2) are arranged, the number of the lodgements corresponds to the number of formed sections. A crossbeam (3) being the lower in the operative position thereof is provided with fixing elements. Rotatable coupled pull rods (4) are provided with clamping elements (5). A demountable crossbeam (6) being the upper in the operative position thereof is also provided with the fixing elements.

Abstract: The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds Fc?RIIIA and/or Fc?RIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by Fc?R is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.

Abstract: An apparatus and a method are provided for generating an optical pulse by using a current pulse. The arrangement is based on a specific semiconductor structure, where a carrier injector is separated from the optically active region by a potential barrier for the injected carriers and on low carrier mobility in the semiconductor component, which features give rise to formation of a current-assisted strong electric field in the optically active region at moderate current densities before positive net gain is achieved. The current-assisted electric field broadens the gain spectrum in the active layer thus suppressing positive net gain and permitting carrier accumulation in the active layer. When the current pulse is stopped, the positive net gain is achieved, giving rise to an optical emission from the active layer.

Abstract: Disclosed is a complex light compensation C plate including at least two C plates representing different dispersion ratio values, respectively. The complex light compensation C plate improves a contrast characteristic of a liquid crystal display device at various viewing angles and has a broadband wavelength dispersion characteristic capable of minimizing color variation depending on various viewing angles in a black state of an LCD.

Abstract: A protective cover for a vehicle comprising a sheet or a web of a flexible material that possesses a property of buckling or curving in the upward direction from the vehicle with the formation of a canopy-type shield for protecting the vehicle from direct sun rays, birds' droppings, etc. The sheet has a length exceeding the length of the upper surface periphery of the vehicle so that the upwardly curved canopy is formed either by applying two oppositely directed forces to the opposite ends of the sheet or by prestressing the sheet. The sheet can be made from plastic or a fabric that incorporates springing metal strips that tend to curve upward when they are in a free state. The sheet can be conveniently stored in wound state in a cylindrical cassette. Storage of the flexible material in a wound state enhances the property of bucking or curving when the sheet is withdrawn from the cassette.

Abstract: Systems and methods that improve search rankings for a search query by using data associated with queries related to the search query are described. In one aspect, a search query is received, a related query related to the search query is determined, an article (such as a web page) associated with the search query is determined, and a ranking score for the article based at least in part on data associated with the related query is determined. Several algorithms and types of data associated with related queries useful in carrying out such systems and methods are described.

Abstract: A method and tool for forming a hem flange pre-hem and a final hem on a sheet metal panel wherein elastomeric tooling elements are used to apply radial compression during a forming operation. The elastomeric tooling elements are compressed and apply pressure to a side of the sheet metal panel, for example an aluminum panel, that is stretched during a forming process step. A foil layer may be placed between the sheet metal blank and the elastomeric tooling element to reduce friction and further improve forming performance.

Abstract: A computer-implemented method generates a computer model of one or more teeth by receiving as input a digital data set of meshes representing the teeth; selecting a curved coordinate system with mappings to and from a 3D space; and generating a function in the curved coordinate system to represent each tooth.

Abstract: The present invention provides methods and compositions comprising a population of alphavirus replicon particles comprising alphavirus replicon RNAs, wherein a first replicon RNA comprises nucleic acid encoding cytomegalovirus pp65 and IE1 protein or immunogenic fragments thereof, and a second replicon RNA comprises nucleic acid encoding cytomegalovirus gB protein or an immunogenic fragment thereof, and wherein each of the two replicon RNAs is contained within a separate alphavirus replicon particle.

Abstract: The invention provides human protein complexes with endonuclease activity. In particular, the invention provides human protein complexes with tRNA splicing endonuclease activity and/or 3? end pre-mRNA endonuclease activity. The invention also provides a splice variant of human Sen2, namely human Sen2deltaEx8, and human protein complexes comprising human Sen2deltaEx8. The human Sen2deltaEx8 complexes have pre-tRNA cleavage activity and/or 3? end pre-mRNA endonuclease activity. The invention also provides human protein complexes with pre-ribosomal RNA cleavage activity. The invention also provides antibodies that immunospecifically bind to a complex described herein or a component thereof, and methods of diagnosing, preventing, treating, managing or ameliorating a disorder utilizing such antibodies. The present invention also provides methods utilizing the complexes described herein, inter alia, in screening, diagnosis, and therapy.

Abstract: A system allows a user to submit an ambiguous search query and to receive potentially disambiguated search results. In one implementation, a search engine's conventional alphanumeric index is translated into a second index that is ambiguated in the same manner as which the user's input is ambiguated. The user's ambiguous search query is compared to this ambiguated index, and the corresponding documents are provided to the user as search results.

Abstract: A multistage optical amplifier includes a fiber amplifier stage having an active optical fiber for imparting gain to an optical signal propagating therethrough and a coupler supplying pump energy to the optical fiber. A planar waveguide amplifier stage is optically coupled to the fiber amplifier stage. The waveguide amplifier including a substrate, an active planar waveguide formed on the substrate for imparting gain to an optical signal propagating therethrough, and at least one waveguide coupler formed on the substrate for coupling pump power to the active planar waveguide.

Abstract: Systems and methods are provided using common-mode-voltage bias circuitry to make common-mode-voltage adjustments to differential driver circuitry in integrated circuit differential communications links. Adjustable bias circuitry may be controlled using static and dynamic control signals. Dynamic control signals can be produced by core logic on a programmable logic device or other integrated circuit. Static control signals can be produced by programmable elements. Bias circuit adjustments made at one end of a differential link can be used to improve performance at either end of the link or can be used to improve power consumption or to balance power and performance considerations. The same integrated circuit design can be used in both AC-coupled and DC-coupled environments. The bias circuitry can be formed from an adjustable current source and adjustable resistor. The current source and adjustable resistors can be controlled by the same control signals.

Abstract: A method of fabricating an integrated circuit can include forming a barrier material layer along lateral side walls and a bottom of a via aperture which is configured to receive a via material that electrically connects a first conductive layer and a second conductive layer, implanting a first alloy element into an interfacial layer over the barrier material layer, depositing an alloy layer over the interfacial layer. The implanted first alloy element is reactive with the barrier material layer to increase resistance to copper diffusion.