Patents by Inventor Sergey Rodin
Sergey Rodin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240141296Abstract: The present invention relates to methods for culturing and isolating cells such as multipotent stem cells or multipotent progenitor cells. The methods of the invention comprise using the human CD105 polypeptide as a cell culture substrate. The cells obtained according to the methods of the invention are capable of forming colony forming unit-fibroblasts (CFU-Fs). Cell lines comprising such cells are useful for the treatment of medical conditions, such as acute respiratory distress syndrome (ARDS).Type: ApplicationFiled: February 24, 2022Publication date: May 2, 2024Inventors: Karl-Henrik Grinnemo, Oscar Simonson, Sergey Rodin
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Patent number: 10829733Abstract: Compositions and processes for culturing human stem cells in vitro in an undifferentiated state are disclosed. In this regard, human embryonic stem cells proliferated and maintained their pluripotency when cultured on plates coated with recombinant laminin-10 (laminin-511).Type: GrantFiled: March 17, 2010Date of Patent: November 10, 2020Assignee: BIOLAMINA ABInventors: Karl Tryggvason, Sergey Rodin, Anna Domogatskaya
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Patent number: 10240124Abstract: The present disclosure related to isolated laminin-521, methods for making recombinant laminin-521, host cells that express recombinant laminin-521, and compositions containing laminin-521. Laminin-521 can maintain stem cells in vitro pluripotency, enable self-renewal, and enable single cell survival of human embryonic stem cells. When pluripotent human embryonic stem cells are cultured on plates coated with recombinant laminin-521 (laminin-11), in the absence of differentiation inhibitors or feeder cells, the embryonic stem cells proliferate and maintain their pluripotency. It has also been discovered that human recombinant laminin-521 (laminin-11) provides single cell survival of stem cells after complete dissociation into a single cell suspension. Useful cell culture mediums containing at most 3.9 ng/ml of beta fibroblast growth factor (bFGF) are also described herein.Type: GrantFiled: September 19, 2012Date of Patent: March 26, 2019Assignee: BioLamina ABInventors: Karl Tryggvason, Sergey Rodin
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Patent number: 10138292Abstract: The present disclosure related to isolated laminin-521, methods for making recombinant laminin-521, host cells that express recombinant laminin-521, and compositions containing laminin-521. Laminin-521 can maintain stem cells in vitro pluripotency, enable self-renewal, and enable single cell survival of human embryonic stem cells. When pluripotent human embryonic stem cells are cultured on plates coated with recombinant laminin-521 (laminin-11), in the absence of differentiation inhibitors or feeder cells, the embryonic stem cells proliferate and maintain their pluripotency. It has also been discovered that human recombinant laminin-521 (laminin-11) provides single cell survival of stem cells after complete dissociation into a single cell suspension. Useful cell culture mediums containing at most 3.9 ng/ml of beta fibroblast growth factor (bFGF) are also described herein.Type: GrantFiled: December 16, 2011Date of Patent: November 27, 2018Assignee: BIOLAMINA ABInventors: Karl Tryggvason, Sergey Rodin
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Patent number: 9534038Abstract: The present disclosure provides isolated laminin-421, methods for making recombinant laminin-421, and host cells that express recombinant laminin-421. The present disclosure also provides nucleic acid sequences encoding full length human laminin ?2 chain, expression vectors and host cells thereof.Type: GrantFiled: March 1, 2012Date of Patent: January 3, 2017Assignee: BIOLAMINA ABInventors: Karl Tryggvason, Sergey Rodin
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Patent number: 8951799Abstract: The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, that both maintain stem cells in vitro pluripotency and enable self-renewal. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on plates coated with recombinant laminin-10 (laminin-511) or their functional domains, in the absence of differentiation inhibitors or feeder cells, the embryonic stem cells proliferated and maintained their pluripotency.Type: GrantFiled: August 25, 2009Date of Patent: February 10, 2015Assignee: BioLamina ABInventors: Anna Domogatskaya, Sergey Rodin, Karl Tryggvason
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Publication number: 20140315306Abstract: The present disclosure related to isolated laminin-521, methods for making recombinant laminin-521, host cells that express recombinant laminin-521, and compositions containing laminin-521. Laminin-521 can maintain stem cells in vitro pluripotency, enable self-renewal, and enable single cell survival of human embryonic stem cells. When pluripotent human embryonic stem cells are cultured on plates coated with recombinant laminin-521 (laminin-11), in the absence of differentiation inhibitors or feeder cells, the embryonic stem cells proliferate and maintain their pluripotency. It has also been discovered that human recombinant laminin-521 (laminin-11) provides single cell survival of stem cells after complete dissociation into a single cell suspension. Useful cell culture mediums containing at most 3.9 ng/ml of beta fibroblast growth factor (bFGF) are also described herein.Type: ApplicationFiled: September 19, 2012Publication date: October 23, 2014Inventors: Karl Tryggvason, Sergey Rodin
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Patent number: 8722405Abstract: The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, for culturing stem cells in vitro in an undifferentiated state. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on plates coated with recombinant laminin-10 (laminin-511) or laminin-5 (laminin-322), or their functional domains, the embryonic stem cells proliferated and maintained their pluripotency.Type: GrantFiled: January 4, 2008Date of Patent: May 13, 2014Inventors: Karl Tryggvason, Anna Domogatskaya, Sergey Rodin
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Patent number: 8415156Abstract: The present disclosure related to isolated laminin-521, methods for making recombinant laminin-521, host cells that express recombinant laminin-521, and compositions containing laminin-521. Laminin-521 can maintain stem cells in vitro pluripotency, enable self-renewal, and enable single cell survival of human embryonic stem cells. When pluripotent human embryonic stem cells are cultured on plates coated with a matrix of recombinant laminin-521 (laminin 11), in the absence of differentiation inhibitors or feeder cells, the embryonic stem cells proliferate and maintain their pluripotency. It has also been discovered that human recombinant laminin-521 (laminin-11) provides single cell survival of stem cells after complete dissociation into a single cell suspension. Useful cell culture mediums containing at most 3.9 ng/ml of beta fibroblast growth factor (bFGF) are also described herein.Type: GrantFiled: December 16, 2011Date of Patent: April 9, 2013Assignee: Biolamina ABInventors: Karl Tryggvason, Sergey Rodin
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Publication number: 20120302512Abstract: The present disclosure provides isolated laminin-421, methods for making recombinant laminin-421, and host cells that express recombinant laminin-421. The present disclosure also provides nucleic acid sequences encoding full length human laminin ?2 chain, expression vectors and host cells thereof.Type: ApplicationFiled: March 1, 2012Publication date: November 29, 2012Applicant: BioLamina ABInventors: Karl Tryggvason, Sergey Rodin
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Publication number: 20120156782Abstract: The present disclosure related to isolated laminin-521, methods for making recombinant laminin-521, host cells that express recombinant laminin-521, and compositions containing laminin-521. Laminin-521 can maintain stem cells in vitro pluripotency, enable self-renewal, and enable single cell survival of human embryonic stem cells. When pluripotent human embryonic stem cells are cultured on plates coated with recombinant laminin-521 (laminin-11), in the absence of differentiation inhibitors or feeder cells, the embryonic stem cells proliferate and maintain their pluripotency. It has also been discovered that human recombinant laminin-521 (laminin-11) provides single cell survival of stem cells after complete dissociation into a single cell suspension. Useful cell culture mediums containing at most 3.9 ng/ml of beta fibroblast growth factor (bFGF) are also described herein.Type: ApplicationFiled: December 16, 2011Publication date: June 21, 2012Applicant: BioLamina ABInventors: Karl Tryggvason, Sergey Rodin
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Publication number: 20120156254Abstract: The present disclosure related to isolated laminin-521, methods for making recombinant laminin-521, host cells that express recombinant laminin-521, and compositions containing laminin-521. Laminin-521 can maintain stem cells in vitro pluripotency, enable self-renewal, and enable single cell survival of human embryonic stem cells. When pluripotent human embryonic stem cells are cultured on plates coated with a matrix of recombinant laminin-521 (laminin 11), in the absence of differentiation inhibitors or feeder cells, the embryonic stem cells proliferate and maintain their pluripotency. It has also been discovered that human recombinant laminin-521 (laminin-11) provides single cell survival of stem cells after complete dissociation into a single cell suspension. Useful cell culture mediums containing at most 3.9 ng/ml of beta fibroblast growth factor (bFGF) are also described herein.Type: ApplicationFiled: December 16, 2011Publication date: June 21, 2012Applicant: BIOLAMINA ABInventors: KARL TRYGGVASON, SERGEY RODIN
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Publication number: 20100323443Abstract: The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, that both maintain stem cells in vitro pluripotency and enable self-renewal. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on plates coated with recombinant laminin-10 (laminin-511) or their functional domains, in the absence of differentiation inhibitors or feeder cells, the embryonic stem cells proliferated and maintained their pluripotency.Type: ApplicationFiled: August 25, 2009Publication date: December 23, 2010Inventors: Anna Domogatskaya, Sergey Rodin, Karl Tryggvason
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Publication number: 20100203635Abstract: Compositions and processes for culturing human stem cells in vitro in an undifferentiated state are disclosed. In this regard, human embryonic stem cells proliferated and maintained their pluripotency when cultured on plates coated with recombinant laminin-10 (laminin-511).Type: ApplicationFiled: March 17, 2010Publication date: August 12, 2010Inventors: Karl Tryggvason, Sergey Rodin, Anna Domogatskaya
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Publication number: 20080213885Abstract: The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, for culturing stem cells in vitro in an undifferentiated state. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on plates coated with recombinant laminin-10 (laminin-511) or laminin-5 (laminin-322), or their functional domains, the embryonic stem cells proliferated and maintained their pluripotency.Type: ApplicationFiled: January 4, 2008Publication date: September 4, 2008Inventors: Karl Tryggvason, Anna Domogatskaya, Sergey Rodin