Patents by Inventor Sergey S Shevkoplyas

Sergey S Shevkoplyas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10908152
    Abstract: The present invention relates to simple, low-cost, rapid paper-based diagnostic devices and their methods of use.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: February 2, 2021
    Assignee: The Administrators Of The Tulane Educational Fund
    Inventors: Sergey S. Shevkoplyas, Xiaoxi Yang, Julie Kanter Washko, Nathaniel Zane Piety
  • Patent number: 10705098
    Abstract: Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: July 7, 2020
    Assignee: Hemanext Inc.
    Inventors: Tatsuro Yoshida, Sergey S. Shevkoplyas, Jennie M. Burns
  • Publication number: 20180306818
    Abstract: Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.
    Type: Application
    Filed: April 18, 2018
    Publication date: October 25, 2018
    Applicants: New Health Sciences, Inc., The Administrators of the Tulane Educational Fund
    Inventors: Tatsuro YOSHIDA, Sergey S. SHEVKOPLYAS, Jennie M. BURNS
  • Patent number: 9977037
    Abstract: Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: May 22, 2018
    Assignees: New Health Sciences, Inc., The Administrators of the Tulane Educational Fund
    Inventors: Tatsuro Yoshida, Sergey S. Shevkoplyas, Jennie M. Burns
  • Publication number: 20180093023
    Abstract: Described are devices, methods, and kits for controlled incremental filtration (CIF), as well as methods of designing CIF devices. For example, a method for CIF may modulate a concentration of particles of a desired size in a fluid. The fluid including the particles may be flowed along a flow path through a central channel to contact a plurality of gaps that fluidically couple the central channel to at least one adjacent side channel network. Flow resistance may be decreased along at least a portion of the flow path effective to modulate the concentration of particles. The method may include selecting the plurality of gaps to be larger than the particles. The method may include causing a consistent flow fraction fgap in the central channel to traverse each gap in the plurality of gaps and flow through the at least one side channel network along the flow path.
    Type: Application
    Filed: October 16, 2017
    Publication date: April 5, 2018
    Inventors: Sean C. GIFFORD, Sergey S. SHEVKOPLYAS
  • Patent number: 9789235
    Abstract: Described are devices, methods, and kits for controlled incremental filtration (CIF), as well as methods of designing CIF devices. For example, a method for CIF may modulate a concentration of particles of a desired size in a fluid. The fluid including the particles may be flowed along a flow path through a central channel to contact a plurality of gaps that fluidically couple the central channel to at least one adjacent side channel network. Flow resistance may be decreased along at least a portion of the flow path effective to modulate the concentration of particles. The method may include selecting the plurality of gaps to be larger than the particles. The method may include causing a consistent flow fraction fgap in the central channel to traverse each gap in the plurality of gaps and flow through the at least one side channel network along the flow path.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: October 17, 2017
    Assignees: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, HALCYON BIOMEDICAL, INCORPORATED
    Inventors: Sean C. Gifford, Sergey S. Shevkoplyas
  • Publication number: 20170023556
    Abstract: The present invention relates to simple, low-cost, rapid paper-based diagnostic devices and their methods of use.
    Type: Application
    Filed: July 20, 2016
    Publication date: January 26, 2017
    Applicant: The Administrators of The Tulane Educational Fund
    Inventors: Sergey S. Shevkoplyas, Xiaoxi Yang, Julie Kanter Washko, Nathaniel Zane Piety
  • Patent number: 9551706
    Abstract: The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: January 24, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Scott T. Phillips, George M. Whitesides, Katherine A. Mirica, Emanuel Carrilho, Andres W. Martinez, Sergey S. Shevkoplyas, Phillip W. Snyder, Raquel Perez-Castillejos, Malancha Gupta, Adam Winkleman, Katherine L. Gudiksen
  • Patent number: 9409265
    Abstract: The ability to assemble three-dimensional structures using diamagnetic particles suspended in solutions containing paramagnetic cations is described. The major advantages of this separation device are that: (i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) the assembled structures can be removed from the paramagnetic solution for further processing after fixing the structure; iii) the assembly is fast; and iv) it is small, portable.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: August 9, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Whitesides, Filip Ilievski, Audrey Ellerbee, Sergey S. Shevkoplyas, Katherine A. Mirica
  • Patent number: 9383350
    Abstract: A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then released from the base layer to produce a free-standing thin film comprising the tissue on the flexible polymer layer. In one embodiment, the cells are myocytes, which can be actuated to propel or displace the free-standing film. In another embodiment, the free-standing film is used to treat injured human tissue.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: July 5, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: Kevin Kit Parker, Adam W. Feinberg, George M. Whitesides, Sergey S. Shevkoplyas, Alexander Feigel
  • Publication number: 20150202549
    Abstract: Described are devices, methods, and kits for controlled incremental filtration (CIF), as well as methods of designing CIF devices. For example, a method for CIF may modulate a concentration of particles of a desired size in a fluid. The fluid including the particles may be flowed along a flow path through a central channel to contact a plurality of gaps that fluidically couple the central channel to at least one adjacent side channel network. Flow resistance may be decreased along at least a portion of the flow path effective to modulate the concentration of particles. The method may include selecting the plurality of gaps to be larger than the particles. The method may include causing a consistent flow fraction fgap in the central channel to traverse each gap in the plurality of gaps and flow through the at least one side channel network along the flow path.
    Type: Application
    Filed: January 20, 2015
    Publication date: July 23, 2015
    Inventors: Sean C. Gifford, Sergey S. Shevkoplyas
  • Publication number: 20150153367
    Abstract: Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.
    Type: Application
    Filed: May 22, 2013
    Publication date: June 4, 2015
    Applicants: The Administrators of the Tulane Educational Fund, New Health Sciences, Inc.
    Inventors: Tatsuro Yoshida, Sergey S. Shevkoplyas, Jennie M. Burns
  • Publication number: 20140295472
    Abstract: A device utilizing agglutination and its method of use to diagnose diseases or conditions. The diagnostic device may comprise a substrate having pores, an agglutination zone, and a test readout zone wherein said agglutination zone is functionalized with an agglutinating agent to cause agglutination of the sample.
    Type: Application
    Filed: November 13, 2012
    Publication date: October 2, 2014
    Applicant: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
    Inventors: Sergey S. Shevkoplyas, Xiaoxi Yang, Julie Kanter Washko, Nathaniel Zane Piety
  • Publication number: 20140123461
    Abstract: The ability to assemble three-dimensional structures using diamagnetic particles suspended in solutions containing paramagnetic cations is described. The major advantages of this separation device are that: (i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) the assembled structures can be removed from the paramagnetic solution for further processing after fixing the structure; iii) the assembly is fast; and iv) it is small, portable.
    Type: Application
    Filed: December 20, 2011
    Publication date: May 8, 2014
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: George M. Whitesids, Filip Iievski, Audrey Ellerbee, Sergey S. Shevkoplyas, Katherine A. Mirica
  • Publication number: 20140004553
    Abstract: A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then released from the base layer to produce a free-standing thin film comprising the tissue on the flexible polymer layer. In one embodiment, the cells are myocytes, which can be actuated to propel or displace the free-standing film. In another embodiment, the free-standing film is used to treat injured human tissue.
    Type: Application
    Filed: June 20, 2013
    Publication date: January 2, 2014
    Inventors: Kevin Kit Parker, Adam W. Feinberg, George M. Whitesides, Sergey S. Shevkoplyas, Alexander Feigel
  • Patent number: 8492150
    Abstract: A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then released from the base layer to produce a free-standing thin film comprising the tissue on the flexible polymer layer. In one embodiment, the cells are myocytes, which can be actuated to propel or displace the free-standing film. In another embodiment, the free-standing film is used to treat injured human tissue.
    Type: Grant
    Filed: February 5, 2007
    Date of Patent: July 23, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: Kevin Kit Parker, Adam W. Feinberg, George M. Whitesides, Sergey S. Shevkoplyas, Alexander Feigel
  • Patent number: 8486833
    Abstract: Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as “microsolidic” devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g.
    Type: Grant
    Filed: May 18, 2006
    Date of Patent: July 16, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: Derek A. Bruzewicz, Mila Boncheva-Bettex, George M. Whitesides, Adam Siegel, Douglas B. Weibel, Sergey S. Shevkoplyas, Andres Martinez
  • Publication number: 20110045577
    Abstract: Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as “microsolidic” devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g.
    Type: Application
    Filed: May 18, 2006
    Publication date: February 24, 2011
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Derek A. Bruzewicz, Mila Boncheva-Bettex, George M. Whitesides, Adam Siegel, Douglas B. Weibel, Sergey S. Shevkoplyas, Andres Martinez
  • Publication number: 20100285606
    Abstract: The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable.
    Type: Application
    Filed: June 30, 2008
    Publication date: November 11, 2010
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Scott T. Phillips, George M. Whitesides, Katherine A. Mirica, Emanuel Carrilho, Andres W. Martinez, Sergey S. Shevkoplyas, Phillip W. Snyder, Raquel Perez-Castillejos, Malancha Gupta, Adam Winkleman, Katherine L. Gudiksen
  • Publication number: 20090317852
    Abstract: A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then released from the base layer to produce a free-standing thin film comprising the tissue on the flexible polymer layer. In one embodiment, the cells are myocytes, which can be actuated to propel or displace the free-standing film. In another embodiment, the free-standing film is used to treat injured human tissue.
    Type: Application
    Filed: February 5, 2007
    Publication date: December 24, 2009
    Inventors: Kevin Kit Parker, Adam W. Feinberg, George M. Whitesides, Sergey S. Shevkoplyas, Alexander Feigel