Patents by Inventor Sergey S Shevkoplyas
Sergey S Shevkoplyas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10908152Abstract: The present invention relates to simple, low-cost, rapid paper-based diagnostic devices and their methods of use.Type: GrantFiled: July 20, 2016Date of Patent: February 2, 2021Assignee: The Administrators Of The Tulane Educational FundInventors: Sergey S. Shevkoplyas, Xiaoxi Yang, Julie Kanter Washko, Nathaniel Zane Piety
-
Patent number: 10705098Abstract: Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.Type: GrantFiled: April 18, 2018Date of Patent: July 7, 2020Assignee: Hemanext Inc.Inventors: Tatsuro Yoshida, Sergey S. Shevkoplyas, Jennie M. Burns
-
Publication number: 20180306818Abstract: Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.Type: ApplicationFiled: April 18, 2018Publication date: October 25, 2018Applicants: New Health Sciences, Inc., The Administrators of the Tulane Educational FundInventors: Tatsuro YOSHIDA, Sergey S. SHEVKOPLYAS, Jennie M. BURNS
-
Patent number: 9977037Abstract: Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.Type: GrantFiled: May 22, 2013Date of Patent: May 22, 2018Assignees: New Health Sciences, Inc., The Administrators of the Tulane Educational FundInventors: Tatsuro Yoshida, Sergey S. Shevkoplyas, Jennie M. Burns
-
Publication number: 20180093023Abstract: Described are devices, methods, and kits for controlled incremental filtration (CIF), as well as methods of designing CIF devices. For example, a method for CIF may modulate a concentration of particles of a desired size in a fluid. The fluid including the particles may be flowed along a flow path through a central channel to contact a plurality of gaps that fluidically couple the central channel to at least one adjacent side channel network. Flow resistance may be decreased along at least a portion of the flow path effective to modulate the concentration of particles. The method may include selecting the plurality of gaps to be larger than the particles. The method may include causing a consistent flow fraction fgap in the central channel to traverse each gap in the plurality of gaps and flow through the at least one side channel network along the flow path.Type: ApplicationFiled: October 16, 2017Publication date: April 5, 2018Inventors: Sean C. GIFFORD, Sergey S. SHEVKOPLYAS
-
Patent number: 9789235Abstract: Described are devices, methods, and kits for controlled incremental filtration (CIF), as well as methods of designing CIF devices. For example, a method for CIF may modulate a concentration of particles of a desired size in a fluid. The fluid including the particles may be flowed along a flow path through a central channel to contact a plurality of gaps that fluidically couple the central channel to at least one adjacent side channel network. Flow resistance may be decreased along at least a portion of the flow path effective to modulate the concentration of particles. The method may include selecting the plurality of gaps to be larger than the particles. The method may include causing a consistent flow fraction fgap in the central channel to traverse each gap in the plurality of gaps and flow through the at least one side channel network along the flow path.Type: GrantFiled: January 20, 2015Date of Patent: October 17, 2017Assignees: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, HALCYON BIOMEDICAL, INCORPORATEDInventors: Sean C. Gifford, Sergey S. Shevkoplyas
-
Publication number: 20170023556Abstract: The present invention relates to simple, low-cost, rapid paper-based diagnostic devices and their methods of use.Type: ApplicationFiled: July 20, 2016Publication date: January 26, 2017Applicant: The Administrators of The Tulane Educational FundInventors: Sergey S. Shevkoplyas, Xiaoxi Yang, Julie Kanter Washko, Nathaniel Zane Piety
-
Patent number: 9551706Abstract: The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable.Type: GrantFiled: June 30, 2008Date of Patent: January 24, 2017Assignee: President and Fellows of Harvard CollegeInventors: Scott T. Phillips, George M. Whitesides, Katherine A. Mirica, Emanuel Carrilho, Andres W. Martinez, Sergey S. Shevkoplyas, Phillip W. Snyder, Raquel Perez-Castillejos, Malancha Gupta, Adam Winkleman, Katherine L. Gudiksen
-
Patent number: 9409265Abstract: The ability to assemble three-dimensional structures using diamagnetic particles suspended in solutions containing paramagnetic cations is described. The major advantages of this separation device are that: (i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) the assembled structures can be removed from the paramagnetic solution for further processing after fixing the structure; iii) the assembly is fast; and iv) it is small, portable.Type: GrantFiled: December 20, 2011Date of Patent: August 9, 2016Assignee: President and Fellows of Harvard CollegeInventors: George M. Whitesides, Filip Ilievski, Audrey Ellerbee, Sergey S. Shevkoplyas, Katherine A. Mirica
-
Patent number: 9383350Abstract: A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then released from the base layer to produce a free-standing thin film comprising the tissue on the flexible polymer layer. In one embodiment, the cells are myocytes, which can be actuated to propel or displace the free-standing film. In another embodiment, the free-standing film is used to treat injured human tissue.Type: GrantFiled: June 20, 2013Date of Patent: July 5, 2016Assignee: President and Fellows of Harvard CollegeInventors: Kevin Kit Parker, Adam W. Feinberg, George M. Whitesides, Sergey S. Shevkoplyas, Alexander Feigel
-
Publication number: 20150202549Abstract: Described are devices, methods, and kits for controlled incremental filtration (CIF), as well as methods of designing CIF devices. For example, a method for CIF may modulate a concentration of particles of a desired size in a fluid. The fluid including the particles may be flowed along a flow path through a central channel to contact a plurality of gaps that fluidically couple the central channel to at least one adjacent side channel network. Flow resistance may be decreased along at least a portion of the flow path effective to modulate the concentration of particles. The method may include selecting the plurality of gaps to be larger than the particles. The method may include causing a consistent flow fraction fgap in the central channel to traverse each gap in the plurality of gaps and flow through the at least one side channel network along the flow path.Type: ApplicationFiled: January 20, 2015Publication date: July 23, 2015Inventors: Sean C. Gifford, Sergey S. Shevkoplyas
-
Publication number: 20150153367Abstract: Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.Type: ApplicationFiled: May 22, 2013Publication date: June 4, 2015Applicants: The Administrators of the Tulane Educational Fund, New Health Sciences, Inc.Inventors: Tatsuro Yoshida, Sergey S. Shevkoplyas, Jennie M. Burns
-
Publication number: 20140295472Abstract: A device utilizing agglutination and its method of use to diagnose diseases or conditions. The diagnostic device may comprise a substrate having pores, an agglutination zone, and a test readout zone wherein said agglutination zone is functionalized with an agglutinating agent to cause agglutination of the sample.Type: ApplicationFiled: November 13, 2012Publication date: October 2, 2014Applicant: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUNDInventors: Sergey S. Shevkoplyas, Xiaoxi Yang, Julie Kanter Washko, Nathaniel Zane Piety
-
Publication number: 20140123461Abstract: The ability to assemble three-dimensional structures using diamagnetic particles suspended in solutions containing paramagnetic cations is described. The major advantages of this separation device are that: (i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) the assembled structures can be removed from the paramagnetic solution for further processing after fixing the structure; iii) the assembly is fast; and iv) it is small, portable.Type: ApplicationFiled: December 20, 2011Publication date: May 8, 2014Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: George M. Whitesids, Filip Iievski, Audrey Ellerbee, Sergey S. Shevkoplyas, Katherine A. Mirica
-
Publication number: 20140004553Abstract: A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then released from the base layer to produce a free-standing thin film comprising the tissue on the flexible polymer layer. In one embodiment, the cells are myocytes, which can be actuated to propel or displace the free-standing film. In another embodiment, the free-standing film is used to treat injured human tissue.Type: ApplicationFiled: June 20, 2013Publication date: January 2, 2014Inventors: Kevin Kit Parker, Adam W. Feinberg, George M. Whitesides, Sergey S. Shevkoplyas, Alexander Feigel
-
Patent number: 8492150Abstract: A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then released from the base layer to produce a free-standing thin film comprising the tissue on the flexible polymer layer. In one embodiment, the cells are myocytes, which can be actuated to propel or displace the free-standing film. In another embodiment, the free-standing film is used to treat injured human tissue.Type: GrantFiled: February 5, 2007Date of Patent: July 23, 2013Assignee: President and Fellows of Harvard CollegeInventors: Kevin Kit Parker, Adam W. Feinberg, George M. Whitesides, Sergey S. Shevkoplyas, Alexander Feigel
-
Patent number: 8486833Abstract: Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as “microsolidic” devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g.Type: GrantFiled: May 18, 2006Date of Patent: July 16, 2013Assignee: President and Fellows of Harvard CollegeInventors: Derek A. Bruzewicz, Mila Boncheva-Bettex, George M. Whitesides, Adam Siegel, Douglas B. Weibel, Sergey S. Shevkoplyas, Andres Martinez
-
Publication number: 20110045577Abstract: Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as “microsolidic” devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g.Type: ApplicationFiled: May 18, 2006Publication date: February 24, 2011Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Derek A. Bruzewicz, Mila Boncheva-Bettex, George M. Whitesides, Adam Siegel, Douglas B. Weibel, Sergey S. Shevkoplyas, Andres Martinez
-
Publication number: 20100285606Abstract: The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable.Type: ApplicationFiled: June 30, 2008Publication date: November 11, 2010Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Scott T. Phillips, George M. Whitesides, Katherine A. Mirica, Emanuel Carrilho, Andres W. Martinez, Sergey S. Shevkoplyas, Phillip W. Snyder, Raquel Perez-Castillejos, Malancha Gupta, Adam Winkleman, Katherine L. Gudiksen
-
Publication number: 20090317852Abstract: A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then released from the base layer to produce a free-standing thin film comprising the tissue on the flexible polymer layer. In one embodiment, the cells are myocytes, which can be actuated to propel or displace the free-standing film. In another embodiment, the free-standing film is used to treat injured human tissue.Type: ApplicationFiled: February 5, 2007Publication date: December 24, 2009Inventors: Kevin Kit Parker, Adam W. Feinberg, George M. Whitesides, Sergey S. Shevkoplyas, Alexander Feigel