Abstract: Pesticidal proteins are provided that combine two or more modes of action into a single molecule. These pesticidal proteins therefor exhibit greater efficacy and/or durability of resistance, for the purposes of pest control, and can be utilized for pest control by provision in the diet of a pest organism, or by topical application to crop plants and/or pests. Methods and compositions for producing and using such proteins are also provided.

Abstract: A heart valve prosthesis includes an annular body, a support having an upstream support surface, a downstream support surface and a side surface facing the central axis of the annular body, and leaflets mounted within the annular body so as to pivot between a closed position in which the blood backflow is restricted and an open position which allows the passage of the direct blood flow. Each leaflet has a contact surface cooperating with the contact surface of the other leaflet in the closed position, an outer side surface, an upstream surface, a downstream surface and support portions respectively interacting with the downstream support surface and the upstream support surface of the support of said annular body.